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Initial Impact of the COVID-19 Outbreak on ADHD Symptoms Among University Students in Japan

Takeda T, Tsuji Y, Akatsu R, Nomura T

Objectives: The coronavirus disease 2019 pandemic and its associated societal responses are anticipated to have wide-ranging effects on youth development and mental health. Depression, anxiety, and attention deficit hyperactivity disorder...
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Rotatable sphincterotome as a rescue device for endoscopic retrograde cholangiopancreatography cannulation: a single-center experience

Okamoto T, Sasaki T, Takeda T, Mie T, Mori C, Furukawa T, Yamada Y, Kasuga A, Matsuyama M, Ozaka M, Sasahira N

Background/Aims: Selective bile duct or pancreatic duct cannulation remains a significant initial hurdle in endoscopic retrograde cholangiopancreatography (ERCP) despite advances in endoscopy and accessories. This study evaluated our experience with...
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Risk factors for recurrent stenosis after balloon dilation for benign hepaticojejunostomy anastomotic stricture

Mie T, Sasaki T, Okamoto T, Takeda T, Mori C, Yamada Y, Furukawa T, Kasuga A, Matsuyama M, Ozaka M, Sasahira N

Background/Aims: Hepaticojejunostomy anastomotic stricture (HJAS) is a feared adverse event associated with hepatopancreatobiliary surgery. Although balloon dilation for benign HJAS during endoscopic retrograde cholangiopancreatography with balloon-assisted enteroscopy has been reported...
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Efficacy of Oral Etidronate for Skeletal Diseases in Japan

Iwamoto J, Takeda T, Sato Y

Etidronate is an oral bisphosphonate compound that is known to reduce bone resorption through the inhibition of osteoclastic activity. The efficacy of etidronate for involutional (postmenopausal and senile) and glucocorticoid-induced...
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Comparison of tube-assisted mapping biopsy with digital single-operator peroral cholangioscopy for preoperative evaluation of biliary tract cancer

Takeda T, Sasaki T, Mie T, Okamoto T, Mori C, Furukawa T, Yamada Y, Kasuga A, Matsuyama M, Ozaka M, Sasahira N

Background/Aims: Digital single-operator cholangioscopy (DSOC)-guided mapping biopsy (DMB) and tube-assisted mapping biopsy (TMB) are two techniques used for preoperative evaluation of biliary tract cancer (BTC). However, data regarding the diagnostic...
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Comparison of Endoscopic Ultrasound-Guided Tissue Acquisition Using a 20-Gauge Menghini Needle with a Lateral Forward Bevel and a 22-Gauge Franseen Needle: A Single-Center Large Cohort Study

Mie T, Sasaki T, Kanata R, Furukawa T, Takeda T, Kasuga A, Matsuyama M, Ozaka M, Sasahira N

Background/Aims: Several fine-needle biopsy (FNB) needles are available for endoscopic ultrasound (EUS)-guided tissue acquisition. However, there is disagreement on which type of needle has the best diagnostic yield. The aim...
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Outcomes of partially covered self-expandable metal stents with different uncovered lengths in endoscopic ultrasound-guided hepaticogastrostomy: a Japanese retrospective study

Okamoto T, Sasaki T, Takeda T, Hirai T, Ishitsuka T, Yamada M, Nakagawa H, Mie T, Furukawa T, Kasuga A, Ozaka M, Sasahira N

Background/Aims: The optimal length of the uncovered portion of partially covered self-expandable metal stents (PCSEMSs) used in endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) remains unclear. This study investigated the safety and efficacy...
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Prevention and Treatment of Corticosteroid-Induced Osteoporosis

Iwamoto J, Takeda T, Sato Y

Osteoporosis is one of the most serious complications of corticosteroid treatment. Loss of bone mineral density (BMD) and fractures occur early in the course of corticosteroid treatment, and thus early...
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Combined Treatment with Vitamin K2 and Bisphosphonate in Postmenopausal Women with Osteoporosis

Iwamoto J, Takeda T, Ichimura S

  • KMID: 2428340
  • Yonsei Med J.
  • 2003 Oct;44(5):751-756.
Vitamin K2, as well as bisphosphonates, such as etidronate, alendronate, and risedronate, is widely used in the treatment with osteoporosis in Japan. Etidronate increases the lumbar bone mineral density (BMD),...
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Effects of Risedronate on Osteoarthritis of the Knee

Iwamoto J, Takeda T, Sato Y, Matsumoto

The purpose of the present study was to discuss the effects of risedronate on osteoarthritis (OA) of the knee by reviewing the existing literature. The literature was searched with PubMed,...
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Screening for Lynch syndrome using risk assessment criteria in patients with ovarian cancer

Takeda T, Tsuji K, Banno K, Yanokura M, Kobayashi , Tominaga E, Aoki D

OBJECTIVE: Lynch syndrome is a cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes. Lynch syndrome only causes about 0.4% of cases of ovarian cancer, which...
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Comparison of Effects of Alendronate and Raloxifene on Lumbar Bone Mineral Density, Bone Turnover, and Lipid Metabolism in Elderly Women with Osteoporosis

Iwamoto J, Sato Y, Uzawa M, Takeda T, Matsumoto

  • KMID: 2396095
  • Yonsei Med J.
  • 2008 Feb;49(1):119-128.
PURPOSE: To compare the effects of alendronate and raloxifene on lumbar bone mineral density (BMD), bone turnover, and lipid metabolism in elderly women with osteoporosis. Subjects and Methods: One hundred...
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LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer

Kunitomi H, Kobayashi , Wu RC, Takeda T, Tominaga E, Banno K, Aoki D

OBJECTIVE: With the emerging significance of genetic profiles in the management of endometrial cancer, the identification of tumor-driving genes with prognostic value is a pressing need. The LAMC1 gene, encoding...
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Differential Effect of Vitamin K and Vitamin D Supplementation on Bone Mass in Young Rats Fed Normal or Low Calcium Diet

Iwamoto J, Takeda T, Ichimura S, Sato Y, Yeh JK

  • KMID: 2428329
  • Yonsei Med J.
  • 2004 Apr;45(2):314-324.
The purpose of this study was to clarify the differential effect of vitamin K and vitamin D supplementation on bone mass in young rats fed a normal or low calcium...
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Effects of Vitamin K2 on the Development of Osteopenia in Rats as the Models of Osteoporosis

Iwamoto J, Takeda T, Sato Y

Vitamin K2 is widely used for the treatment of osteoporosis in Japan. To understand the effects of vitamin K2 on bone mass and bone metabolism, we reviewed its effects on...
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Comparison of Effect of Treatment with Etidronate and Alendronate on Lumbar Bone Mineral Density in Elderly Women with Osteoporosis

Iwamoto J, Takeda T, Sato Y, Uzawa M

  • KMID: 2428289
  • Yonsei Med J.
  • 2005 Dec;46(6):750-758.
The purpose of this open-labeled prospective study was to compare the treatment effects of cyclical etidronate and alendronate on the lumbar bone mineral density (BMD), bone resorption, and back pain...
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Comparison of the Effects of Alendronate and Alfacalcidol on Hip Bone Mineral Density and Bone Turnover in Japanese Men Having Osteoporosis or Osteopenia with Clinical Risk Factors for Fractures

Iwamoto J, Sato Y, Uzawa M, Takeda T, Matsumoto

PURPOSE: The comparative effects of alendronate and alfacalcidol on bone mineral density (BMD) and bone turnover have already been established in postmenopausal women with osteoporosis. An open-labeled prospective study was...
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Influence of Ovariectomy on Bone Turnover and Trabecular Bone Mass in Mature Cynomolgus Monkeys

Iwamoto J, Seki A, Matsuura M, Sato Y, Takeda T, Matsumoto , Yeh JK

PURPOSE: To examine the influence of ovariectomy (OVX) on bone turnover and trabecular bone mass at the 3 clinically important skeletal sites in mature cynomolgus monkeys. MATERIALS AND METHODS: Six...
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Efficacy and safety of adding mizoribine to standard treatment in patients with immunoglobulin A nephropathy: A randomized controlled trial

Hirai K, Ookawara S, Kitano T, Miyazawa H, Ito K, Ueda Y, Kaku Y, Hoshino T, Mori H, Yoshida I, Kubota K, Yamaji Y, Takeda T, Nakamura Y, Tabei K, Morishita

BACKGROUND: Mizoribine (MZR) is an immunosuppressive drug used in Japan for treating patients with lupus nephritis and nephrotic syndrome and has been also reportedly effective in patients with immunoglobulin A...
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Determinants of One-year Response of Lumbar Bone Mineral Density to Alendronate Treatment in Elderly Japanese Women with Osteoporosis

Iwamoto J, Takeda T, Sato Y, Uzawa M

The purpose of this study was to determine factors that could predict the one-year response of the lumbar bone mineral density (BMD) to alendronate treatment in elderly Japanese women with...
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