- Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells
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Lee WJ, Yoo HS, Suh PG, Lim JS, Oh S, Lee YM
- KMID: 1123763
- Exp Mol Med.
- 2004 Oct;36(5):420-427.
FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form. With 20 micrometer of FTY720, sphingosine accumulated in... -
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- Altered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis
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Moon SH, Kim JY, Song EH, Shin MK, Cho YH, Kim NI
- KMID: 2265872
- Ann Dermatol.
- 2013 Aug;25(3):321-326.
- doi: 10.5021/ad.2013.25.3.321
BACKGROUND: Ceramides are the main lipid component of the stratum corneum and are a structurally heterogeneous and complex group of sphingolipids of which sphingoid bases are the basic structural constituents.... -
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- Analysis of a Sphingosine 1-phosphate Receptor hS1P3 in Rat Hepatoma Cells
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Im DS
- KMID: 2285242
- Korean J Physiol Pharmacol.
- 2002 Jun;6(3):139-142.
To examine intracellular signaling of human S1P3 (hS1P3), a sphingosine 1-phosphate (S1P) receptor in plasma membrane, hS1P3 DNA was transfected into RH7777 rat hepatoma cell line, and the inhibition of... -
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- Pro-Inflammatory Role of S1P₃ in Macrophages
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Heo JY, Im DS
- KMID: 2455092
- Biomol Ther.
- 2019 Jul;27(4):373-380.
- doi: 10.4062/biomolther.2018.215
Sphingosine kinase 1 and its product, sphingosine 1-phosphate (S1P), as well as their receptors, have been implicated in inflammatory responses. The functions of receptors S1Pâ‚ and S1Pâ‚‚ on cell motility... -
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- Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1Pâ‚‚) Attenuates Bleomycin-Induced Pulmonary Fibrosis
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Park SJ, Im DS
- KMID: 2447859
- Biomol Ther.
- 2019 May;27(3):318-326.
- doi: 10.4062/biomolther.2018.131
Sphingosine 1-phosphate (S1P) levels are often found to be elevated in serum, bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and experimental mouse models. Although the roles of... -
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- Effects of Sphingosine-1-Phosphate on Neural Differentiation and Neurite Outgrowth in Neuroblastoma Cells
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Lee JH, Jang S, Jeong HS, Park JS
- KMID: 2172241
- Chonnam Med J.
- 2011 Apr;47(1):27-30.
- doi: 10.4068/cmj.2011.47.1.27
Sphingosine-1-phosphate (S1P) is emerging as a new class of second messenger involved in cellular proliferation, differentiation, and apoptosis and is implicated in diverse physiological functions. Despite many studies on the... -
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- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
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Park SJ, Im DS
- KMID: 2367621
- Biomol Ther.
- 2017 Jan;25(1):80-90.
- doi: 10.4062/biomolther.2016.160
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G... -
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- Association of Bone Marrow Sphingosine 1-phosphate Levels with Osteoporotic Hip Fractures
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Ahn SH, Koh JM, Gong EJ, Byun S, Lee SY, Kim BJ, Lee SH, Chang JS, Kim GS
- KMID: 2286295
- J Bone Metab.
- 2013 Nov;20(2):61-65.
- doi: 10.11005/jbm.2013.20.2.61
BACKGROUND: Sphingosine 1-phosphate (S1P) has been discovered to be a critical regulator of bone metabolism. Very recently, we found that higher circulating S1P levels were associated with higher rate of... -
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- Sphingosine 1-Phosphate Triggers Apoptotic Signal for B16 Melanoma Cells via ERK and Caspase Activation
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Shin JH, Choi GS, Kang WH, Myung KB
- KMID: 1713191
- J Korean Med Sci.
- 2007 Apr;22(2):298-304.
- doi: 10.3346/jkms.2007.22.2.298
The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), recently was reported to induce apoptosis of some cancer cells and neurons, although it generally known to exert mitogenic and antiapoptotic effects. In... -
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- The Effect of Sphingosine-1-Phosphate in Survival of Grafted Fat Tissues
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Yoon DJ, Choi SJ, Choi CW, Nam SB, Bae YC
- KMID: 2120569
- J Korean Soc Plast Reconstr Surg.
- 2010 Nov;37(6):726-731.
PURPOSE: Autologous fat grafting is a popular procedure for the correction of the soft tissue depression and deformity. But there are several issues required to be carefully considered in relation... -
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- Prolonged ERK Activation of S1P on B16 Melanoma Cells
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Lee HS, Choi GS, Shin JH
- KMID: 2248133
- Korean J Dermatol.
- 2008 Jun;46(6):769-775.
BACKGROUND: The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), was reported to induce apoptosis of some cancer cells and neurons, although it is generally known to exert mitogenic and antiapoptotic effects.... -
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- Protective Effects of K6PC-5, A Sphingosine Kinase Activator, Against 1-methyl-4-phenylpyridinium-induced Dopaminergic Neuronal Cell Death
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Jang S, Choi SS, Kim SH, Park JS, Jeong HS
- KMID: 2172296
- Chonnam Med J.
- 2008 Dec;44(3):162-168.
- doi: 10.4068/cmj.2008.44.3.162
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metaolite, regulates multiple cellular responses such as Ca2+ signaling, cellular growth and survival, and differentiation. Sphingosine kinase (SphK) is a key enzyme in modulating the... -
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- Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation
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Hong SW, Lee J, Kwon H, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY
- KMID: 2447031
- Endocrinol Metab.
- 2018 Sep;33(3):403-412.
- doi: 10.3803/EnM.2018.33.3.403
BACKGROUND: Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current... -
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- Dietary effect of silk protein on epidermal levels of free sphingoid bases and phosphate metabolites in NC/Nga mice
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Kim Y, Song EH, Shin K, Lee Y, Cho Y
- KMID: 2268660
- Korean J Nutr.
- 2012 Apr;45(2):113-120.
- doi: 10.4163/kjn.2012.45.2.113
In our previous studies, dietary supplements of silk protein, sericin, and fibroin, were beneficial for improving epidermal levels of ceramides, which are the major lipids for maintaining the epidermal barrier.... -
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- Intracellular signal transduction of interleukin-6 production bylipopolysaccharide-stimulated fibroblasts
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Joo JH, Ki SY, Moon SH, Jung SH, Kim HT, Uh ST, Kim YH, Park CS
- KMID: 2143163
- Korean J Med.
- 1998 Mar;54(3):415-422.
OBJECTIVES: Stimulation of cell results in a variety of early biochemical events, known as signal transduction pathway and ultimately leads to final outcome like cell proliferation or cytokine production. The... -
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- Challenges and Pitfalls of Stroke Therapeutics Research
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Jung KH
- KMID: 2288739
- Korean J Stroke.
- 2011 Apr;13(1):11-15.
Ischemia-reperfusion injury is complicated with multiple injury pathways. If a particular agent is used to restore blood flow and prevent cell death, many damaged neurons may come back to life.... -
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- A Global Gene Expression Analysis of the Peripheral Blood Mononuclear Cells Reveals the Gene Expression Signature in Psoriasis
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Lee SK, Jeon EK, Kim YJ, Seo SH, Kim CD, Lim JS, Lee JH
- KMID: 2266283
- Ann Dermatol.
- 2009 Aug;21(3):237-242.
- doi: 10.5021/ad.2009.21.3.237
BACKGROUND: Psoriasis is a chronic inflammatory skin disease that affects approximately 1~3% of the general population. OBJECTIVE: We performed cDNA microarray analysis with using the dendrimer labelling method to investigate the... -
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- High Plasma Sphingosine 1-phosphate Levels Predict Osteoporotic Fractures in Postmenopausal Women: The Center of Excellence for Osteoporosis Research Study
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Ardawi MS, Rouzi AA, Al-Senani , Qari MH, Elsamanoudy AZ, Mousa SA
- KMID: 2413370
- J Bone Metab.
- 2018 May;25(2):87-98.
- doi: 10.11005/jbm.2018.25.2.87
BACKGROUND: Higher sphingosine 1-phosphate (S1P) plasma levels are associated with decreased bone mineral density (BMD), and increased risk of prevalent vertebral fracture. So, we hypothesized that postmenopausal women with increased... -
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- Altered Sphingolipid Metabolism Is Associated With Asthma Phenotype in House Dust Mite-Allergic Patients
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Kowal K, Żebrowska E, Chabowski
- KMID: 2442045
- Allergy Asthma Immunol Res.
- 2019 May;11(3):330-342.
- doi: 10.4168/aair.2019.11.3.330
PURPOSE: Sphingolipids play an important role in cell growth, survival, inflammation and tissue remodeling. House dust mite (HDM) allergy is a major risk factor for asthma. The aim of the... -
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