Korean J Stroke.  2011 Apr;13(1):11-15.

Challenges and Pitfalls of Stroke Therapeutics Research

• Jung KH

Abstract

Ischemia-reperfusion injury is complicated with multiple injury pathways. If a particular agent is used to restore blood flow and prevent cell death, many damaged neurons may come back to life. However, for stroke victims, there are no effective curative therapeutic approaches available other than thrombolytic treatment. The efficacy of neuroprotective agents are limited by low diffusion, narrow time window, strict dose titration, and lack of confidence at the preclinical level. NXY-059 reflects the fundamental limitation of neuroprotectant. There are recent attempts to overcome these limitations, with use of annexin A2, fingolimod, hydrogen, nitrite, and more. By covering two components, this report reviews what we have recently learned. In addition, it sheds light on some of the newer issues in clinical application.

Keyword

Stroke; Therapeutics; Research; Neuroprotectant

MeSH Terms

Annexin A2
Benzenesulfonates
Cell Death
Diffusion
Hydrogen
Light
Multiple Trauma
Neurons
Neuroprotective Agents
Propylene Glycols
Reperfusion Injury
Sphingosine
Stroke
Fingolimod Hydrochloride
Annexin A2
Benzenesulfonates
Hydrogen
Neuroprotective Agents
Propylene Glycols
Sphingosine