J Korean Neurosurg Soc.  2022 Mar;65(2):161-172. 10.3340/jkns.2021.0126.

Recent Stem Cell Research on Hemorrhagic Stroke : An Update

• Kim JT
• Youn DH
• Kim BJ
• Rhim JK
• Jeon JP

• KMID: 2527172
• DOI: http://doi.org/10.3340/jkns.2021.0126

Abstract

Although technological advances and clinical studies on stem cells have been increasingly reported in stroke, research targeting hemorrhagic stroke is still lacking compared to that targeting ischemic stroke. Studies on hemorrhagic stroke are also being conducted, mainly in the USA and China. However, little research has been conducted in Korea. In reality, stem cell research or treatment is unfamiliar to many domestic neurosurgeons. Nevertheless, given the increased interest in regenerative medicine and the increase of life expectancy, attention should be paid to this topic. In this paper, we summarized pre-clinical rodent studies and clinical trials using stem cells for hemorrhagic stroke. In addition, we discussed results of domestic investigations and future perspectives on stem cell research for a better understanding.

Keyword

Stem cell; Hemorrhage stroke; Therapeutics

Figure

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  Fig. 1. Sources of stem cells used for treating hemorrhagic stroke. MSC : mesenchymal stem cell, NSC : neural stem cell, iPSC : induced pluripotent stem cell, ESC : embryonic stem cell, ICH : intracerebral hemorrhage, IVH : intraventricular hemorrhage, SAH : subarachnoid hemorrhage.

Reference

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