- The anti-Influenza effect of a water soluble herbal extract from Salvia miltiorrhiza (Danshen) in vivo
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Lee ES, Kim MS, Weeratunga P, Lee HC, Chathuranga K, Ma JY, Kim HI, Lee JS
- KMID: 2436123
- J Biomed Transl Res.
- 2018 Mar;19(1):21-25.
- doi: 10.12729/jbtr.2018.19.1.021
Salvia miltiorrhiza (Danshen) is perennial plant and commonly used in traditional Chinese medicine to treat numerous diseases like cardiovascular and cerebrovascular diseases, coronary heart disease, myocardial infarction, stroke and some... -
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- Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation
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Moon S, Shin S, Kim S, Oh HE, Han S, Lee S, Kim K
- KMID: 2168001
- Immune Netw.
- 2011 Oct;11(5):288-298.
- doi: 10.4110/in.2011.11.5.288
BACKGROUND: Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved. METHODS: The effects of an ethanol extract of... -
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- Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro
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Hur JM, Shim JS, Jung HJ, Kwon HJ
- KMID: 755752
- Exp Mol Med.
- 2005 Apr;37(2):133-137.
In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of... -
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- Salvia miltiorrhiza Bunge Blocks Ethanol-Induced Synaptic Dysfunction through Regulation of NMDA Receptor-Dependent Synaptic Transmission
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Park HJ, Lee S, Jung JW, Lee YC, Choi SM, Kim DH
- KMID: 2351693
- Biomol Ther.
- 2016 Jul;24(4):433-437.
- doi: 10.4062/biomolther.2015.184
Consumption of high doses of ethanol can lead to amnesia, which often manifests as a blackout. These blackouts experienced by ethanol consumers may be a major cause of the social... -
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- Salvia miltiorrhiza Inhibits Tumor Cell Growth in Association with Rb Dephosphorylation through Up-regulation of p21 Via a p53-dependent Pathway
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Chung J, Chang JE, Son YH, Park HR, Lim SH, Oh YH, Lee MY, Park YM
- KMID: 1571388
- Immune Netw.
- 2002 Mar;2(1):19-24.
- doi: 10.4110/in.2002.2.1.19
BACKGROUND: Salvia miltiorrhiza (SM), a traditional oriental medicine, has been reported to have anti-tumor properties, but its exact mechanism remains to be elucidated. In this study, we investigated several of... -
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- Inhibition of Arterial Myogenic Responses by a Mixed Aqueous Extract of Salvia Miltiorrhiza and Panax Notoginseng (PASEL) Showing Antihypertensive Effects
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Baek EB, Yoo HY, Park SJ, Chung YS, Hong EK, Kim SJ
- KMID: 2071683
- Korean J Physiol Pharmacol.
- 2009 Aug;13(4):287-293.
- doi: 10.4196/kjpp.2009.13.4.287
The dried roots of Danshen (Salvia miltiorrhiza) and Sanchi (Panax notoginseng) have been widely used in traditional Chinese medicine for promoting blood circulation as well as various other bodily functions.... -
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- Anti-proliferative Effect of 15,16-Dihydrotanshinone I Through Cell Cycle Arrest and the Regulation of AMP-activated Protein Kinase/Akt/mTOR and Mitogen-activated Protein Kinase Signaling Pathway in Human Hepatocellular Carcinoma Cells
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Hong JY, Park SH, Park HJ, Lee SK
- KMID: 2417368
- J Cancer Prev.
- 2018 Jun;23(2):63-69.
- doi: 10.15430/JCP.2018.23.2.63
BACKGROUND: 15,16-dihydrotanshinone I (DHTS) is a natural abietane diterpenoid that is mainly found in the roots of Salvia miltiorrhiza Bunge (Labiatae). DHTS exhibits a potential anti-proliferative effect in various human... -
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- Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia
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Lee JC, Park JH, Park OK, Kim IH, Yan BC, Ahn JH, Kwon SH, Choi JH, Kim JD, Won MH
- KMID: 2263144
- Anat Cell Biol.
- 2013 Sep;46(3):183-190.
- doi: 10.5115/acb.2013.46.3.183
Hypoxia-ischemia leads to serious neuronal damage in some brain regions and is a strong risk factor for stroke. The aim of this study was to investigate the neuroprotective effect of... -
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- 2-(4-Hydroxyphenyl)-5-(3-Hydroxypropenyl)-7-Methoxybenzofuran, a Novel Ailanthoidol Derivative, Exerts Anti-Inflammatory Effect through Downregulation of Mitogen-Activated Protein Kinase in Lipopolysaccharide-Treated RAW 264.7 Cells
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Kim HJ, Jun JG, Kim JK
- KMID: 1429301
- Korean J Physiol Pharmacol.
- 2013 Jun;17(3):217-222.
- doi: 10.4196/kjpp.2013.17.3.217
We reported that ailanthoidol, a neolignan from Zanthoxylum ailanthoides and Salvia miltiorrhiza Bunge, inhibited inflammatory reactions by macrophages and protected mice from endotoxin shock. We examined the anti-inflammatory activity of... -
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- Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats
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Paik YH, Yoon YJ, Lee HC, Jung MK, Kang SH, Chung SI, Kim JK, Cho JY, Lee KS, Han KH
- KMID: 1107375
- Exp Mol Med.
- 2011 Jun;43(6):341-349.
- doi: 10.3858/emm.2011.43.6.037
Magnesium lithospermate B (MLB) is one of the major active components of Salvia miltiorrhizae. The anti-oxidative effects of Salvia miltiorrhizae have been previously reported. The aim of this study was... -
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- Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells
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Zhang X, Luo W, Zhao W, Lu J, Chen X
- KMID: 2374525
- J Breast Cancer.
- 2015 Jun;18(2):112-118.
- doi: 10.4048/jbc.2015.18.2.112
PURPOSE: Isocryptotanshinone (ICTS) is a natural bioactive product that is isolated from the roots of the widely used medical herb Salvia miltiorrhiza. However, few reports exist on the mechanisms underlying... -
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- Tanshinone IIA Protects Endothelial Cells from Hâ‚‚Oâ‚‚-Induced Injuries via PXR Activation
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Zhu H, Chen Z, Ma Z, Tan H, Xiao C, Tang X, Zhang B, Wang Y, Gao Y
- KMID: 2395809
- Biomol Ther.
- 2017 Nov;25(6):599-608.
- doi: 10.4062/biomolther.2016.179
Tanshinone IIA (Tan IIA) is a pharmacologically active substance extracted from the rhizome of Salvia miltiorrhiza Bunge (also known as the Chinese herb Danshen), and is widely used to treat... -
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- Cryptotanshinone inhibits TNF-α-induced LOX-1 expression by suppressing reactive oxygen species (ROS) formation in endothelial cells
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Ran X, Zhao W, Li W, Shi J, Chen X
- KMID: 2371052
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):347-355.
- doi: 10.4196/kjpp.2016.20.4.347
Cryptotanshinone (CPT) is a natural compound isolated from traditional Chinese medicine Salvia miltiorrhiza Bunge. In the present study, the regulatory effect and potential mechanisms of CPT on tumor necrosis factor... -
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- Effects of the Combination Herbal Extract on Working Memory and White Matter Integrity in Healthy Individuals with Subjective Memory Complaints : A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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Kwon O, Lee S, Ban S, Im JJ, Lee DS, Lee EH, Kim J, Lim SM, Lee SG, Kang I, Kim KH, Yoon S, Lee SH
- KMID: 2299829
- Korean J Biol Psychiatry.
- 2015 May;22(2):63-77.
- doi: 10.0000/kjbp.2015.22.2.63
OBJECTIVES: The combination extract of four kinds of herbs, Gastrodia elata, Liriope platyphylla, Dimocarpus longan, and Salvia miltiorrhiza, has shown to have memory improving effects in mice. The aim of... -
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- Protocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1
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Deng Y, Guo W, Li G, Li S, Li H, Li X, Niu B, Song M, Zhang Y, Xu Z, Li F
- KMID: 2470879
- J Breast Cancer.
- 2020 Feb;23(1):20-35.
- doi: 10.4048/jbc.2020.23.e7
PURPOSE: C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that is overexpressed in many cancers. CtBP1 transcriptionally represses a broad array of tumor suppressors, which promotes cancer cell proliferation,... -
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- Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan
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Kang ES, Kim BS, Kim CH, Seo GH, Han SJ, Chun SW, Hur KY, Ahn CW, Ha H, Jung M, Cha BS, Lee HC
- KMID: 2298105
- Korean Diabetes J.
- 2008 Feb;32(1):10-20.
- doi: 10.4093/kdj.2008.32.1.10
BACKGROUND: Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. We examined... -
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- Effect of herbal extracts on bone regeneration in a rat calvaria defect model and screening system
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Lee DH, Kim IK, Cho HY, Seo JH, Jang JM, Kim J
- KMID: 2410584
- J Korean Assoc Oral Maxillofac Surg.
- 2018 Apr;44(2):79-85.
- doi: 10.5125/jkaoms.2018.44.2.79
OBJECTIVES: The aim of this study was to evaluate the effects of herbal extracts on bone regeneration. Two known samples were screened. MATERIALS AND METHODS: We previously established a rat calvaria... -
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