Exp Mol Med.  2005 Apr;37(2):133-137.

Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro

Affiliations
  • 1Chemical Genomics National Research Laboratory, Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, 98 Gunja-dong, Gwangjin-gu, Seoul, Korea. kwonhj@sejong.ac.kr

Abstract

In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S. miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity.

Keyword

abietane; angiogenesis; cryptotanshinone; Salvia miltiorrhiza; tanshinone
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