Exp Mol Med.  2005 Apr;37(2):133-137.

Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro

• Hur JM
• Shim JS
• Jung HJ
• Kwon HJ

Abstract

In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S. miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity.

Keyword

abietane; angiogenesis; cryptotanshinone; Salvia miltiorrhiza; tanshinone

MeSH Terms

Angiogenesis Inhibitors/chemistry/isolation & purification/*pharmacology
Animals
Cattle
Cell Movement/drug effects
Cell Proliferation/drug effects
Cells, Cultured
Drugs, Chinese Herbal/chemistry/isolation & purification/pharmacology
Endothelial Cells/drug effects/physiology
Fibroblast Growth Factor 2/pharmacology
Humans
Neovascularization, Physiologic/drug effects
Phenanthrenes/chemistry/isolation & purification/*pharmacology
Plant Roots/chemistry
Research Support, Non-U.S. Gov't
Salvia miltiorrhiza/*chemistry