- Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis
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Park JH, Park GM, Kim JK
- KMID: 2285576
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):335-340.
- doi: 10.4196/kjpp.2015.19.4.335
Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and... -
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- Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis
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Lee SH, Jeong D, Han YS, Baek MJ
- KMID: 2047707
- Ann Surg Treat Res.
- 2015 Jul;89(1):1-8.
- doi: 10.4174/astr.2015.89.1.1
The shaping of new blood vessels is a significant event in cancer growth and metastasis. Therefore, the molecular system of cancer angiogenesis has garnered considerable interest in cancer research. The... -
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- IMMUNOHISTOCHEMICAL STUDY ON EXPRESSION OF LYMPHANGIOGENIC FACTORS IN ORAL CANCER
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Park YW, Kwon KJ, Lee JW
- KMID: 2005089
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2010 Jan;32(1):1-8.
BACKGROUND AND PURPOSE: Vascular endothelial growth factor (VEGF)-C and VEGF receptor (VEGFR)-3 are involved in tumor lymphangiogenesis. Oral mucosal squamous cell carcinoma (OMSCC) preferentially metastasizes to cervical lymph nodes, so... -
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- Increased expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 after pilocarpine-induced status epilepticus in mice
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Cho KO, Kim JY, Jeong KH, Lee MY, Kim SY
- KMID: 2450495
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):281-289.
- doi: 10.4196/kjpp.2019.23.4.281
Vascular endothelial growth factor (VEGF)-C and its receptor, vascular endothelial growth factor receptor (VEGFR)-3, are responsible for lymphangiogenesis in both embryos and adults. In epilepsy, the expression of VEGF-C and... -
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- Targeting Receptor Tyrosine Kinase on Endothelial Cells in an Orthotopic Tumor Model of Oral Squamous Cell Carcinorma
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Park YW, Kim SH
- KMID: 2328427
- J Korean Assoc Oral Maxillofac Surg.
- 2009 Apr;35(2):55-65.
PURPOSE: We determined the therapeutic effects of blockade of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinases on the growth of oral squamous cell carcinoma... -
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- Metastasis via Peritumoral Lymphatic Dilation in Oral Squamous Cell Carcinoma
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Kim HS, Park YW
- KMID: 1910868
- Maxillofac Plast Reconstr Surg.
- 2014 May;36(3):85-93.
PURPOSE: Nodal metastasis is the main prognostic factor in the patients with oral squamous cell carcinoma (OSCC). We investigated the association between tumor-associated lymphatics and OSCC characteristics. METHODS: Thirty-four specimens were... -
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- Vascular Endothelial Growth Factor Enhances Axonal Outgrowth in Organotypic Spinal Cord Slices via Vascular Endothelial Growth Factor Receptor 1 and 2
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Park HW, Jeon HJ, Chang MS
- KMID: 2360809
- Tissue Eng Regen Med.
- 2016 Oct;13(5):601-609.
- doi: 10.1007/s13770-016-0051-9
Enhancing adult nerve regeneration is a potential therapeutic strategy for treating spinal cord injury. Vascular endothelial growth factor (VEGF) is a major contributor to angiogenesis, which can reduce the spinal... -
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- Expression of Vascular Endothelial Growth Factor Receptor mRNA in Eutopic and Ectopic Endometrial Tissues of Patients with Endometriosis
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Park JY, Kim CH, Hong SH, Lee YJ, Hong SW, Kwon HE, Kim SH, Chae HD, Kang BM
- KMID: 2019489
- Korean J Obstet Gynecol.
- 2004 Mar;47(3):515-522.
OBJECTIVE: To Investigate the expression of vascular endothelial growth factor receptor-1, -2, and -3 (VEGFR-1, -2, and -3) mRNA in the eutopic and ectopic tissues in women with endometriosis. METHODS: At... -
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- Effect of Anti-vascular Endothelial Growth Factor Antibody on the Survival of Cultured Retinal Ganglion Cells
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Lee JM, Bae HW, Lee SY, Seong GJ, Kim CY
- KMID: 2385586
- Korean J Ophthalmol.
- 2017 Aug;31(4):360-365.
- doi: 10.3341/kjo.2017.0054
PURPOSE: To investigate the effects of anti-vascular endothelial growth factor (VEGF) antibody on the survival of retinal ganglion cell (RGC)-5 cells differentiated with staurosporine under oxidative stress. METHODS: We used real-time... -
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- Bevacizumab in Recurrent Glioma: Patterns of Treatment Failure and Implications
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Li Y, Ali S, Clarke J, Cha S
- KMID: 2378298
- Brain Tumor Res Treat.
- 2017 Apr;5(1):1-9.
- doi: 10.14791/btrt.2017.5.1.1
Glioblastoma, the most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. Bevacizumab, a monoclonal antibody against the vascular endothelial growth factor receptor,... -
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- The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer
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Goulart A, Ferreira C, Rodrigues , Coimbra B, Sousa N, Leão P
- KMID: 2450985
- Ann Surg Treat Res.
- 2019 Jul;97(1):15-20.
- doi: 10.4174/astr.2019.97.1.15
PURPOSE: Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer... -
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- Cellular and molecular characterization of adenoid cystic carcinoma of the salivary glands
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Park YW
- KMID: 2183812
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2005 Mar;27(2):110-122.
Adenoid cystic carcinoma (ACC) of salivary glands has a protracted clinical course with perineural invasion, delayed onset of hematogenous metastasis, and poor responses to classical cytotoxic chemotherapic agents. Most... -
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- Delay of Spontaneous Neutrophil Apoptosis by Vascular Endothelial Growth Factor
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Jeon CW, Park HY, Kwak JY, Kim HH
- KMID: 2210210
- J Korean Surg Soc.
- 2005 Oct;69(4):328-334.
PURPOSE: Vascular endothelial growth factor (VEGF) stimulates angiogenesis and vascular permeability. Tissue damage is related to angiogenesis, and induced by a delay in neutrophil apoptosis. This study was performed to... -
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- Expression of the mRNA of Growth Factor Receptors and Neurotrophic Factors in Porcine Vesical Submucosa and Acellular Matrix
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Moon HC, Joo KJ, Park HJ
- KMID: 2293814
- Korean J Urol.
- 2005 Dec;46(12):1344-1347.
PURPOSE: Several naturally-derived biopolymers have been introduced as implantable biomaterial for tissue reconstruction, and some of them are already being applied in various clinical fields. They serve as backbones for... -
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- Stevens-Johnson Syndrome Induced by Vandetanib
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Yoon J, Oh CW, Kim CY
- KMID: 2171868
- Ann Dermatol.
- 2011 Dec;23(Suppl 3):S343-S345.
- doi: 10.5021/ad.2011.23.S3.S343
Vandetanib is a once-daily oral anticancer drug that selectively inhibits key signaling pathways in cancer by targeting vascular endothelial growth factor receptors, epidermal growth factor receptors tyrosine kinase, and rearranged... -
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- Differences in Expression of VEGF-A, VEGFR-1, VEGFR-2 and Microvessel Density in Colorectal Cancer with Liver Metastasis
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Jeong EH, Kim Y, Min BW, Lee KH, Kim HS, Lee JH
- KMID: 2277533
- Korean J Pathol.
- 2010 Dec;44(6):571-580.
BACKGROUND: Colorectal cancer (CRC) is one of the most common malignant neoplasms and is a leading cause of mortality worldwide. Metastasis to the liver is a frequent event in patients... -
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- Target Therapy for Hepatocellular Carcinoma
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Yoon SK
- KMID: 2168205
- Hanyang Med Rev.
- 2012 May;32(2):118-125.
- doi: 10.7599/hmr.2012.32.2.118
Hepatocellular carcinoma (HCC) is a highly malignant tumor that has limited treatment options in its advanced state. The efficacy of current anti-cancer chemotherapy in advanced HCC has not been satisfactory,... -
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- Inhibition of Lymphatic Endothelial Growth Factor Receptor in a Murine Model of Oral Squamous Cell Carcinoma
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Kye JY, Park YW
- KMID: 2136910
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2011 Jan;33(1):1-9.
PURPOSE: Tumor associated angiogenesis and/or lymphangiogenesis are known to be linked by VEGFR signaling pathways. These processes are regulated by several growth factors including VEGFR-2, VEGFR-3. E7080 is an orally... -
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- Clinical Significance of Vascular Endothelial Growth Factors (VEGF)-C and -D in Resected Non-Small Cell Lung Cancer
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Ko YH, Jung CK, Lee MA, Byun JH, Kang JH, Lee KY, Jo KH, Wang YP, Hong YS
- KMID: 1804615
- Cancer Res Treat.
- 2008 Sep;40(3):133-140.
PURPOSE: Lymphatic spread of tumor is an important prognostic factor for patients with non-small cell lung carcinoma (NSCLC). Vascular endothelial growth factor-C (VEGF-C) and VEGF-D play important roles in lymphangiogenesis... -
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- Intravitreal injection of anti-vascular endothelial growth factor for patients with various retinal diseases
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Kang S
- KMID: 2195168
- J Korean Med Assoc.
- 2016 Jan;59(1):52-57.
- doi: 10.5124/jkma.2016.59.1.52
Vascular endothelial growth factor (VEGF-A) is a major regulator of angiogenesis and vascular permeability. VEGF-A plays an important role in a wide variety of retinal diseases. Therefore, intravitreal injection of... -
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