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The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes: Implications for Bone Metabolism

Sawatsubashi S, Nishimura , Mori J, Kouzmenko , Kato S

Vitamin D (VD) is essential for bone health, and VD or its analogues are widely used in clinics to ameliorate bone loss. The targets and mode of VD anti-osteoporotic actions...
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The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders

Altun H, Kurutaş E, Şahin N, Güngör O, Fındıklı E

OBJECTIVE: Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome with an increasingly prevalent etiology, yet not fully understood. It has been thought that vitamin D, complex B vitamin levels...
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Vitamin D Status and Vitamin D Receptor Gene Polymorphisms Are Associated with Pelvic Floor Disorders in Women

Ahn JH, Noh YH, Um KJ, Kim HS, Cho S

OBJECTIVES: To investigate if vitamin D receptor (VDR) gene polymorphisms and circulating vitamin D levels are associated with pelvic floor disorders (PFDs). METHODS: In this case-control study, 25-hydroxy-vitamin D (25[OH]D) serum...
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Vitamin D Receptor Gene, Matrix Metalloproteinase 3 Polymorphisms and the Risk of Intervertebral Disc Degeneration Susceptibility: Meta-Analysis

Nong L, Huang Y, Zhao S, Xu N

Several studies have evaluated the association between vitamin D receptor, matrix metalloproteinase 3 (MMP-3) polymorphisms and the risk of intervertebral disc degeneration susceptibility. The findings were inconsistent. This meta-analysis aimed...
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Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin

Lee KY, Choi HS, Choi HS, Chung KY, Lee BJ, Maeng HJ, Seo MD

The vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily. The VDR binds to active vitamin D3 metabolites, which stimulates downstream transduction signaling involved in various...
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Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population

Hong YJ, Kang ES, Ji MJ, Choi HJ, Oh T, Koong SS, Jeon HJ

BACKGROUND: Type 2 diabetes is one of the most common diseases with devastating complications. However, genetic susceptibility of diabetic complications has not been clarified. The vitamin D endocrine system is...
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Expression of Vitamin D Receptor in Seminal Vesicles of Cholesterol Formula Mice

Kim TH, Lee HH, Kim JM, Choi SD, Lee A, Hwang SY, Kim M, Kim YS, Yeom S

OBJECTIVES: Genomic function of vitamin D receptor (VDR) indicates spermatogenesis that is important for in male reproductive organ authors evaluated the VDR expression in seminal vesicles with high cholesterol (HC)...
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Vitamin D Receptor Poly(A) Microsatellite Polymorphism and 25-Hydroxyvitamin D Serum Levels: Association with Susceptibility to Breast Cancer

Colagar AH, Firouzjah , Halalkhor

PURPOSE: According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR). There is growing evidence that breast cancer incidence is associated with...
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Vitamin D Receptor Genotype is Associated with Secondary Hyperparathyroidism in Hemodialysis Patients

Yoon SI, Oh TK, Kwon SK, Kim HY

  • KMID: 2079687
  • Korean J Nephrol.
  • 2007 May;26(3):320-326.
PURPOSE: It is known that secondary hyperparathyroidism in end stage renal disease (ESRD) patients is associated with vitamin D receptor (VDR) gene polymorphism, but there is no consensus on its...
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Association of Calcium Intake and Bone Mineral Density by Vitamin D Receptor Genotype among Elderly Women Living in Rural a Area

Kim JS, Kim HS

  • KMID: 2235938
  • Korean J Community Nutr.
  • 2006 Aug;11(4):534-540.
Recent studies have shown that environmental, biochemical, nutritional or genetic factors affect bone mineral density (BMD). The purpose of the present study was to investigate the effect of vitamin D...
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Vitamin D Receptor Gene BsaM I Polymorphism as Genetic Marker in Patients with Calcium Stone

Seo IY, Park KW, Park SC, Lee SJ, Kim MS, Kim JJ, Rim JS

  • KMID: 2293257
  • Korean J Urol.
  • 2004 Nov;45(11):1143-1147.
PURPOSE: To identify candidate genes related with urolithiasis, the vitamin D receptor (VDR) gene polymorphisms were searched. MATERIALS AND METHODS: Between July 2002 and June 2003, 212 healthy subjects, used as...
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The Relationship between Vitamin D Receptor Gene Polymorphisms and the Effect of Hormone Replacement Therapy on Bone Mineral Density in Postmenopausal Korean Women

Kim JG, Kim SH, Choi YM, Moon SY, Lee JY

  • KMID: 2272041
  • Korean J Obstet Gynecol.
  • 2003 May;46(5):984-990.
OBJECTIVE: to investigate whether vitamin D receptor (VDR) gene polymorphisms are associated with the effect of hormone replacement therapy (HRT) on bone mineral density (BMD) in postmenopausal Korean women. METHODS: The...
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Association of Vitamin D Receptor, Estrogen Receptor, Transforming Growth Factor-beta1 and Interleukin-6 Gene Polymorphism with Bone Mass in Postmenopausal Korean Women

Kwon DJ, You YO, Kim DH, Jo HH, Kim JH, Jong BW, Lim YT, Kim EJ, Lee JW, Kim JH

  • KMID: 2272031
  • Korean J Obstet Gynecol.
  • 2003 May;46(5):913-921.
OBJECTIVE: To evaluate the relationship between vitamin D receptor (VDR), estrogen receptor (ER), transforming growth factor-beta1 (TGF-beta1) and interleukin-6 (IL-6) gene polymorphism, and bone mineral density (BMD). MATERIALS AND METHODS: Restriction...
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Relationship Between Poly (A) Microsatellite in Vitamin D Receptor Gene, and Bone Mineral Density in Postmenopausal Korean Women

Kim JG, Kwon JH, Kim SH, Choi YM, Moon SY, Lee JY

  • KMID: 2272012
  • Korean J Obstet Gynecol.
  • 2003 Apr;46(4):795-801.
OBJECTIVE: To investigate a poly (A) microsatellite in vitamin D receptor (VDR) gene and to evaluate its relationship with bone mineral density (BMD) in postmenopausal Korean women. METHODS: The poly (A)...
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Vitamin D Receptor Gene 3' End Polymorphisms in Patients with Graves' Disease in Koreans

Hwang JK, Kim KW, Kim TY, Lee HS, Park YJ, Shin CS, Park DJ, Park KS, Rhee BD, Kim SY, Lee HK, Cho BY

  • KMID: 2200123
  • J Korean Soc Endocrinol.
  • 2003 Feb;18(1):12-23.
BACKGROUND: The aim of this study was to evaluate the association of vitamin D receptor (VDR) gene polymorphisms with Graves' disease in Koreans. We also investigated the association of VDR...
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Relationship between vitamin D receptor gene polymorphism, and bone mineral density in postmenopausal Korean women

Kim JG, Kwon JH, Kim SH, Choi YM, Moon SY, Lee JY

  • KMID: 2076742
  • Korean J Obstet Gynecol.
  • 2002 Nov;45(11):1982-1990.
OBJECTIVE: To investigate the relationship between vitamin D receptor (VDR) gene polymorphisms and bone mineral density (BMD) in postmenopausal Korean women, and to evaluate if VDR gene polymorphisms are associated...
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Lack of association between rheumatoid arthritis and vitamin D receptor polymorphisms in Koreans

Yoon WC, Kim CG, Song YH, Kim SG, Joen CH, Kim OD, Choe JY

  • KMID: 2252915
  • Korean J Med.
  • 2002 Feb;62(2):209-217.
BACKGROUND: The purpose of this study was to determine whether the distribution of vitamin D receptor (VDR) polymorphisms in rheumatoid arthritis (RA) patients group is different from that of the...
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The Vitamin D Receptor Start Codon Polymorphism (SCP) and Bone Mineral Density in Korean Women

Chung DJ, Cheon NI, Lee CH, Cho DH, Kang HC, Chung MY, Park JT, Yang SW

  • KMID: 2274996
  • Chonnam Med J.
  • 2001 Sep;37(3):277-283.
Bone mineral density (BMD) is thought to be under strong genetic control. Polymorphisms of the vitamin D receptor (VDR) gene have recently been suggested to account for some of the...
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Association Between Peak Bone Mass and Genetic Polymorphisms of the Vitamin D Receptor, Estrogen Receptor, and Type I Collagen 1 Genes in Healthy Young Korean Women

Kim HK, Kim SW, Kim ES, Kim GS

  • KMID: 2331160
  • J Korean Soc Endocrinol.
  • 2001 Feb;16(1):97-114.
BACKGROUND: Genetic suggest that strongest effect is observed in the premenopausal peak bone mass, which become less with age. However, the evaluation of candidate genes polymorphisms has been most frequently...
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A Relationship Between Polymorphism of Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women of Korea

Lee JY, Chung HW, Kim HR, Ahn JJ, Yoo HK

  • KMID: 2075729
  • Korean J Obstet Gynecol.
  • 1999 Apr;42(4):880-886.
OBJECTIVE: The goal of this study was to determine the relationship between BMD and polymorphism of vitamine D receptor gene. METHOD: We amplified exon 2 of VDR and its digestion...
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