Korean J Nephrol.  2007 May;26(3):320-326.

Vitamin D Receptor Genotype is Associated with Secondary Hyperparathyroidism in Hemodialysis Patients

• Yoon SI
• Oh TK
• Kwon SK
• Kim HY

Abstract

PURPOSE: It is known that secondary hyperparathyroidism in end stage renal disease (ESRD) patients is associated with vitamin D receptor (VDR) gene polymorphism, but there is no consensus on its genotype. There is lack of data in Ca, P, calcitriol and VDR polymorphism.
METHODS
We measured serum Ca, P, alkaline phosphatase, parathyroid hormone (PTH), and 1,25 (OH)2D3 of the 53 hemodialysis patients. The genotypes of VDR were classified BB, Bb, bb according to restriction patterns in PCR of the patients' DNA using Bsm I restriction enzyme.
RESULTS
The patients with BB, Bb, bb type were 0 (0%), 15 (28.3%), 38 (71.7%) respectively. Serum PTH levels were 70.0+/-63.3 pg/mL and 146.9+/-184.9 pg/mL in Bb, bb type respectively, and showed significant statistical difference (p<0.05). Serum 1,25 (OH)2D3 levels were 7.68+/-3.41 pg/mL and 6.59+/-2.67 pg/mL in Bb and bb genotype respectively without statistical significance. And there was no significant statistical differences among the serum levels of calcium, phosphorus, alkaline phosphatase.
CONCLUSION
Vitamin D receptor gene polymorphism is associated with secondary hyperparathyroidism in hemodialysis patients, and the b allelle is suggestive of poorer bone mineral metabolism.

Keyword

Hyperparathyroidism; Receptors Calcitriol; Polymorphism Genetic; Renal dialysis

MeSH Terms

Alkaline Phosphatase
Calcitriol
Calcium
Consensus
DNA
Genotype
Humans
Hyperparathyroidism
Hyperparathyroidism, Secondary*
Kidney Failure, Chronic
Metabolism
Parathyroid Hormone
Phosphorus
Polymerase Chain Reaction
Receptors, Calcitriol*
Renal Dialysis*
Vitamin D*
Vitamins*
Alkaline Phosphatase
Calcitriol
Calcium
DNA
Parathyroid Hormone
Phosphorus
Receptors, Calcitriol
Vitamin D
Vitamins