Endocrinol Metab.  2015 Dec;30(4):469-474. 10.3803/EnM.2015.30.4.469.

Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population

• Hong YJ
• Kang ES
• Ji MJ
• Choi HJ
• Oh T
• Koong SS
• Jeon HJ

• KMID: 2169654
• DOI: http://doi.org/10.3803/EnM.2015.30.4.469

Abstract

BACKGROUND
Type 2 diabetes is one of the most common diseases with devastating complications. However, genetic susceptibility of diabetic complications has not been clarified. The vitamin D endocrine system is related with calcification and lipolysis, insulin secretion, and may be associated with many complicated disease including diabetes and cardiovascular disease. Recent studies reported that single nucleotide polymorphisms of vitamin D receptor (VDR) gene were associated with diabetic complications.
METHODS
In present study, we evaluated the association of BsmI polymorphism of VDR with diabetic complications in Korean diabetes patients. Total of 537 type 2 diabetic subjects from the Endocrinology Clinic of Chungbuk National University Hospital were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to test the genotype and allele frequency of BsmI (rs1544410; BB, Bb, bb) polymorphisms.
RESULTS
Mean age was 62.44+/-10.64 years and mean disease duration was 13.65+/-7.39 years. Patients with B allele (BB or Bb) was significantly associated with lower risk of diabetic retinopathy (severe non-proliferative diabetic retinopathy or proliferative retinopathy; 7.4%, 5/68) compared with patients without B allele (bb; 17.3%, 81/469; P=0.035). This association was also significant after adjusting for hemoglobin A1c level, body mass index, age, sex, and diabetes mellitus duration, concurrent dyslipidemia and hypertension (odds ratio, 2.99; 95% confidence interval, 1.08 to 8.29; P=0.035) in logistic regression analysis.
CONCLUSION
Our findings suggest that B allele of Bsm1 polymorphism in VDR gene is associated with lower risk of diabetic retinopathy in type 2 diabetic patients. Bsm1 genotype could be used as a susceptibility marker to predict the risk of diabetes complication.

Keyword

Diabetes mellitus, type 2; Diabetic retinopathy; Polymorphism, single nucleotide; Receptors, calcitriol

MeSH Terms

Alleles
Body Mass Index
Cardiovascular Diseases
Chungcheongbuk-do
Diabetes Complications
Diabetes Mellitus
Diabetes Mellitus, Type 2
Diabetic Retinopathy*
Dyslipidemias
Endocrine System
Endocrinology
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Hypertension
Insulin
Lipolysis
Logistic Models
Polymorphism, Single Nucleotide
Receptors, Calcitriol*
Vitamin D*
Vitamins*
Insulin
Receptors, Calcitriol
Vitamin D
Vitamins

Figure

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  Fig. 1 BsmI and ApaI sites.

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