J Bone Metab.  2017 Aug;24(3):155-159. 10.11005/jbm.2017.24.3.155.

Gestational Diabetes Mellitus, Fetal Growth and Vitamin D

• Yoon HK

• KMID: 2415953
• DOI: http://doi.org/10.11005/jbm.2017.24.3.155

Abstract

Vitamin D is an important secosteroid hormone in skeletal and non-skeletal systems. Vitamin D has relevance to muscle and immune function, hypertension, diabetes mellitus, cancer, and pregnancy because vitamin D receptors (VDR) are present in many non-skeletal tissues. Vitamin D acts on target tissues via the binding of its active form to VDR. As vitamin D affects not only bone metabolism but also glucose metabolism, vitamin D deficiency may affect the development of gestational diabetes mellitus and fetal growth. Although vitamin D deficiency is prevalent during pregnancy, there are conflicting reports on the effect of vitamin D deficiency on pregnancy complications, such as fetal growth restriction and gestational diabetes. This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.

Keyword

Diabetes; Gestational; Fetal development; Vitamin D

MeSH Terms

Diabetes Mellitus
Diabetes, Gestational*
Female
Fetal Development
Glucose
Hypertension
Metabolism
Pregnancy
Pregnancy Complications
Receptors, Calcitriol
Vitamin D Deficiency
Vitamin D*
Vitamins*
Glucose
Receptors, Calcitriol
Vitamin D
Vitamins

Reference

1. Liu NQ, Hewison M. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys. 2012; 523:37–47.

2. Mulligan ML, Felton SK, Riek AE, et al. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2010; 202:429.e1–429.e9.

3. Dror DK, Allen LH. Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutr Rev. 2010; 68:465–477.

4. Barrett H, McElduff A. Vitamin D and pregnancy: an old problem revisited. Best Pract Res Clin Endocrinol Metab. 2010; 24:527–539.

5. Joergensen JS, Lamont RF, Torloni MR. Vitamin D and gestational diabetes: an update. Curr Opin Clin Nutr Metab Care. 2014; 17:360–367.

6. Pittas AG, Lau J, Hu FB, et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007; 92:2017–2029.

7. Weyer C, Bogardus C, Mott DM, et al. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999; 104:787–794.

8. Hu FB, Meigs JB, Li TY, et al. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes. 2004; 53:693–700.

9. Johnson DD, Wagner CL, Hulsey TC, et al. Vitamin D deficiency and insufficiency is common during pregnancy. Am J Perinatol. 2011; 28:7–12.

10. Wendland EM, Torloni MR, Falavigna M, et al. Gestational diabetes and pregnancy outcomes--a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria. BMC Pregnancy Childbirth. 2012; 12:23.

11. Boyle VT, Thorstensen EB, Mourath D, et al. The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort. Br J Nutr. 2016; 116:1409–1415.

12. Park S, Yoon HK, Ryu HM, et al. Maternal vitamin D deficiency in early pregnancy is not associated with gestational diabetes mellitus development or pregnancy outcomes in Korean pregnant women in a prospective study. J Nutr Sci Vitaminol (Tokyo). 2014; 60:269–275.

13. Tomedi LE, Simhan HN, Bodnar LM. Early-pregnancy maternal vitamin D status and maternal hyperglycaemia. Diabet Med. 2013; 30:1033–1039.

14. Baker AM, Haeri S, Camargo CA Jr, et al. First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study. Diabetes Metab Res Rev. 2012; 28:164–168.

15. Savvidou MD, Akolekar R, Samaha RB, et al. Maternal serum 25-hydroxyvitamin D levels at 11(+0) -13(+6) weeks in pregnant women with diabetes mellitus and in those with macrosomic neonates. BJOG. 2011; 118:951–955.

16. Makgoba M, Nelson SM, Savvidou M, et al. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care. 2011; 34:1091–1093.

17. Lacroix M, Battista MC, Doyon M, et al. Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus. Acta Diabetol. 2014; 51:609–616.

18. Zhang C, Qiu C, Hu FB, et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One. 2008; 3:e3753.

19. Poel YH, Hummel P, Lips P, et al. Vitamin D and gestational diabetes: a systematic review and meta-analysis. Eur J Intern Med. 2012; 23:465–469.

20. Aghajafari F, Nagulesapillai T, Ronksley PE, et al. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ. 2013; 346:f1169.

21. Triunfo S, Lanzone A, Lindqvist PG. Low maternal circulating levels of vitamin D as potential determinant in the development of gestational diabetes mellitus. J Endocrinol Invest. 2017; DOI: 10.1007/s40618-017-0696-9.

22. Miliku K, Vinkhuyzen A, Blanken LM, et al. Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes. Am J Clin Nutr. 2016; 103:1514–1522.

23. Lee DH, Ryu HM, Han YJ, et al. Effects of serum 25-hydroxy-vitamin D and fetal bone growth during pregnancy. J Bone Metab. 2015; 22:127–133.

24. Rodriguez A, Garcia-Esteban R, Basterretxea M, et al. Associations of maternal circulating 25-hydroxyvitamin D3 concentration with pregnancy and birth outcomes. BJOG. 2015; 122:1695–1704.

25. Walsh JM, Kilbane M, McGowan CA, et al. Pregnancy in dark winters: implications for fetal bone growth? Fertil Steril. 2013; 99:206–211.

26. Young BE, McNanley TJ, Cooper EM, et al. Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents. Am J Clin Nutr. 2012; 95:1103–1112.

27. Ioannou C, Javaid MK, Mahon P, et al. The effect of maternal vitamin D concentration on fetal bone. J Clin Endocrinol Metab. 2012; 97:E2070–E2077.

28. Mahon P, Harvey N, Crozier S, et al. Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res. 2010; 25:14–19.

29. Galthen-Sorensen M, Andersen LB, Sperling L, et al. Maternal 25-hydroxyvitamin D level and fetal bone growth assessed by ultrasound: a systematic review. Ultrasound Obstet Gynecol. 2014; 44:633–640.

30. Pérez-López FR, Pasupuleti V, Mezones-Holguin E, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2015; 103:1278–1288.e4.