J Bone Metab.  2017 Aug;24(3):155-159. 10.11005/jbm.2017.24.3.155.

Gestational Diabetes Mellitus, Fetal Growth and Vitamin D

• Yoon HK

• KMID: 2415953
• DOI: http://doi.org/10.11005/jbm.2017.24.3.155

Abstract

Vitamin D is an important secosteroid hormone in skeletal and non-skeletal systems. Vitamin D has relevance to muscle and immune function, hypertension, diabetes mellitus, cancer, and pregnancy because vitamin D receptors (VDR) are present in many non-skeletal tissues. Vitamin D acts on target tissues via the binding of its active form to VDR. As vitamin D affects not only bone metabolism but also glucose metabolism, vitamin D deficiency may affect the development of gestational diabetes mellitus and fetal growth. Although vitamin D deficiency is prevalent during pregnancy, there are conflicting reports on the effect of vitamin D deficiency on pregnancy complications, such as fetal growth restriction and gestational diabetes. This article reviews published papers on the effects of vitamin D on gestational diabetes and fetal growth.

Keyword

Diabetes; Gestational; Fetal development; Vitamin D

MeSH Terms

Diabetes Mellitus
Diabetes, Gestational*
Female
Fetal Development
Glucose
Hypertension
Metabolism
Pregnancy
Pregnancy Complications
Receptors, Calcitriol
Vitamin D Deficiency
Vitamin D*
Vitamins*
Glucose
Receptors, Calcitriol
Vitamin D
Vitamins