- Inhibition of indoxyl sulfate-induced intrarenal renin-angiotensin system activation: targeting the aryl hydrocarbon receptor
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Akbar MF
- KMID: 2390929
- Transl Clin Pharmacol.
- 2017 Sep;25(3):114-116.
- doi: 10.12793/tcp.2017.25.3.114
Indoxyl sulfate, a protein-bound uremic toxin, leads to CKD (chronic kidney disease) progression and its complications through the activation of AhR (aryl hydrocarbon receptor) and RAS (renin-angiotensin system). Inhibition of... -
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- Fluoranthene-Induced Cytotoxicity and Direct Effect of Aryl Hydrocarbon Receptor Antagonist on Hematopoietic Stem Cell Differentiation
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Yang SH, Kang MG, Kim HR, Lee YE, Na BR, Lee JH, Shin JH, Shin MG
- KMID: 2450955
- Ann Lab Med.
- 2019 Nov;39(6):580-583.
- doi: 10.3343/alm.2019.39.6.580
No abstract available. -
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- Particulate Matter-Induced Aryl Hydrocarbon Receptor Regulates Autophagy in Keratinocytes
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Jang HS, Lee JE, Myung CH, Park JI, Jo CS, Hwang JS
- KMID: 2462884
- Biomol Ther.
- 2019 Nov;27(6):570-576.
- doi: 10.4062/biomolther.2019.025
Particulate matter (PM), which refers to the mixture of particles present in the air, can have harmful effects. Damage to cells by PM, including disruption of organelles and proteins, can... -
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- Ginsenoside Rb1 Inhibits Doxorubicin-Triggered H9C2 Cell Apoptosis via Aryl Hydrocarbon Receptor
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Zhang Y, Wang Y, Ma Z, Liang Q, Tang X, Tan H, Xiao C, Gao Y
- KMID: 2375041
- Biomol Ther.
- 2017 Mar;25(2):202-212.
- doi: 10.4062/biomolther.2016.066
Doxorubicin (DOX) is a highly effective chemotherapeutic agent; however, the dose-dependent cardiotoxicity associated with DOX significantly limits its clinical application. In the present study, we investigated whether Rb1 could prevent... -
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- Effect of Dialysis on Aryl Hydrocarbon Receptor Transactivating Activity in Patients with Chronic Kidney Disease
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Kim JT, Kim SH, Min HK, Jeon SJ, Sung SA, Park WH, Lee HK, Choi HS, Pak YK, Lee SY
- KMID: 2466336
- Yonsei Med J.
- 2020 Jan;61(1):56-63.
- doi: 10.3349/ymj.2020.61.1.56
PURPOSE: Elevated aryl hydrocarbon receptor (AhR) transactivating (AHRT) activity and uremia in chronic kidney disease (CKD) may interact with each other, further complicating the disease course. In this study, we... -
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- Aryl Hydrocarbon Receptor Ligands Indoxyl 3-sulfate and Indole-3-carbinol Inhibit FMS-like Tyrosine Kinase 3 Ligand-induced Bone Marrow-derived plasmacytoid Dendritic Cell Differentiation
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Hwang WB, Kim DJ, Oh GS, Park JH
- KMID: 2424201
- Immune Netw.
- 2018 Oct;18(5):e35.
- doi: 10.4110/in.2018.18.e35
Aryl hydrocarbon receptor (AhR) regulates both innate and adaptive immune responses by sensing a variety of small synthetic and natural chemicals, which act as its ligands. AhR, which is expressed... -
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- 3,3'-Diindolylmethane Inhibits Flt3L/GM-CSF-induced-bone Marrow-derived CD103+ Dendritic Cell Differentiation Regulating Phosphorylation of STAT3 and STAT5
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Park JH, Choi AJ, Kim SJ, Jeong SY
- KMID: 2132702
- Immune Netw.
- 2015 Dec;15(6):278-290.
- doi: 10.4110/in.2015.15.6.278
The intestinal immune system maintains oral tolerance to harmless antigens or nutrients. One mechanism of oral tolerance is mediated by regulatory T cell (Treg)s, of which differentiation is regulated by... -
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- Regulation of CYP1A1 and Inflammatory Cytokine by NCOA7 Isoform 4 in Response to Dioxin Induced Airway Inflammation
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Cho SH, Park SY, Lee EJ, Cho YH, Park HS, Hong SH, Kim WJ
- KMID: 2320601
- Tuberc Respir Dis.
- 2015 Apr;78(2):99-105.
- doi: 10.4046/trd.2015.78.2.99
BACKGROUND: Aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, binds to a wide variety of synthetic and naturally occurring compounds. AhR is involved in the regulation of inflammatory response during... -
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- Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells
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Hoque MM, Lee YE, Kim HR, Shin MG
- KMID: 2466590
- Blood Res.
- 2019 Dec;54(4):253-261.
- doi: 10.5045/br.2019.54.4.253
BACKGROUND: Fluoranthene (FR) is a common environmental pollutant that exists in a complex mixture with other polycyclic aromatic hydrocarbons (PAHs). We identified biomarkers for monitoring FR exposure and investigated the... -
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- Signaling pathway for 2,3,7,8-tetrachlorodibenzo- p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages
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Cheon HJ, Woo YS, Lee JY, Kim HS, Kim HJ, Cho S, Won NH, Sohn J
- KMID: 756076
- Exp Mol Med.
- 2007 Aug;39(4):524-534.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a prototypic halogenated aromatic hydrocarbon (HAH), is known as one of the most potent toxicants. At least a part of its toxic effects appears to be derived from... -
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- Neurotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in cerebellar granule cells
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Kim SY, Yang JH
- KMID: 1033102
- Exp Mol Med.
- 2005 Feb;37(1):58-64.
An environmental pollutant, tetrachloro dibenzo dioxin (TCDD) is known to illicit the cognitive disability and motor dysfunction in the developing brain. TCDD induced effects leading to neurodevelopmental and neurobehavioral deficit... -
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- 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Induced Cell-Specific Drug Transporters With Acquired Cisplatin Resistance in Cisplatin Sensitive Cancer Cells
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Gotovdorj , Lee E, Lim Y, Cha EJ, Kwon D, Hong E, Kim Y, Oh MY
- KMID: 1794595
- J Korean Med Sci.
- 2014 Sep;29(9):1188-1198.
- doi: 10.3346/jkms.2014.29.9.1188
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce drug transporter genes such as the ATP-binding cassette G member 2 (ABCG2), which contributes to multidrug resistance. We investigated the effect of TCDD pretreatment on drug... -
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