- Expression of Protease-activated Receptor 2 in Nasal Polyp: Immunohistochemical Study
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Lee SK, Park YS, Jeon EJ, Cho JH, Park YJ, Kang JM, Kim MW
- KMID: 2276387
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Apr;48(4):466-470.
BACKGROUND AND OBJECTIVES: Protease-activated receptor 2 (PAR-2) has been known to play an important role in modulating homeostasis and inflammation in the airways. But only a little is known about... -
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- The Clinical Assessment of Protease-Activated Receptor-2 Expression in Inflammatory Cells from Peripheral Blood and Bronchoalveolar Lavage Fluid in Idiopathic Pulmonary Fibrosis
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Park YS, Yoo CG
- KMID: 2320426
- Tuberc Respir Dis.
- 2013 Jun;74(6):264-268.
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a lethal pulmonary fibrotic disease. In general, the exaggerated activation of the coagulation cascade has been observed during initiation or maintenance of the fibrotic... -
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- The Role of Protease Activated Receptors and Proteases in Subtly Inflamed Diarrhea-Predominant Irritable Bowel Syndrome
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Jo Y
- KMID: 1711309
- Korean J Gastroenterol.
- 2014 Jan;63(1):59-61.
- doi: 10.4166/kjg.2014.63.1.59
No abstract available. -
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- Suppression of Peripheral Sympathetic Activity Underlies Protease-Activated Receptor 2-Mediated Hypotension
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Kim YH, Ahn DS, Joeng JH, Chung S
- KMID: 2285551
- Korean J Physiol Pharmacol.
- 2014 Dec;18(6):489-495.
- doi: 10.4196/kjpp.2014.18.6.489
Protease-activated receptor (PAR)-2 is expressed in endothelial cells and vascular smooth muscle cells. It plays a crucial role in regulating blood pressure via the modulation of peripheral vascular tone. Although... -
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- Increased Expression of Cathelicidin by Direct Activation of Protease-Activated Receptor 2: Possible Implications on the Pathogenesis of Rosacea
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Kim JY, Kim YJ, Lim BJ, Sohn HJ, Shin D, Oh SH
- KMID: 2070215
- Yonsei Med J.
- 2014 Nov;55(6):1648-1655.
- doi: 10.3349/ymj.2014.55.6.1648
PURPOSE: Recent findings of increased cathelicidin protein and its proteolytic fragments in rosacea suggest a pathogenic role for cathelicidin in this disease. The relationship between cathelicidin and protease-activated receptor 2... -
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- Protease-Activated Receptor-2 Is Associated with Terminal Differentiation of Epidermis and Eccrine Sweat Glands
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Shin YS, Kim HW, Kim CD, Kim HW, Park JW, Jung S, Lee JH, Ko YK, Lee YH
- KMID: 2171490
- Ann Dermatol.
- 2015 Aug;27(4):364-370.
- doi: 10.5021/ad.2015.27.4.364
BACKGROUND: Protease-activated receptor 2 (PAR-2) participates in various biological activities, including the regulation of epidermal barrier homeostasis, inflammation, pain perception, and melanosome transfer in the skin. OBJECTIVE: To evaluate the basic... -
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- Regional Differences in Chronic Stress-induced Alterations in Mast Cell and Protease-activated Receptor-2-positive Cell Numbers in the Colon of Ws/Ws Rats
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Kim YS, Lee MY, Ryu HS, Choi ES, Oh JT, Yun KJ, Choi SC
- KMID: 2381149
- J Neurogastroenterol Motil.
- 2014 Jan;20(1):54-63.
BACKGROUND/AIMS: There have been no reports on the effect of chronic psychological stress on colonic immune cells or the regional differences. We aimed to investigate the effect of chronic psychological... -
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- Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome
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Liang WJ, Zhang G, Luo HS, Liang LX, Huang D, Zhang FC
- KMID: 2411965
- Gut Liver.
- 2016 May;10(3):382-390.
- doi: 10.5009/gnl14319
BACKGROUND/AIMS: Previous studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS). The levels of... -
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- Protease and Protease-Activated Receptor-2 Signaling in the Pathogenesis of Atopic Dermatitis
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Lee SE, Jeong SK, Lee SH
- KMID: 1779625
- Yonsei Med J.
- 2010 Nov;51(6):808-822.
- doi: 10.3349/ymj.2010.51.6.808
Proteases in the skin are essential to epidermal permeability barrier homeostasis. In addition to their direct proteolytic effects, certain proteases signal to cells by activating protease-activated receptors (PARs), the G-protein-coupled... -
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- The Cockroach and Allergic Diseases
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Sohn MH, Kim KE
- KMID: 2167044
- Allergy Asthma Immunol Res.
- 2012 Sep;4(5):264-269.
- doi: 10.4168/aair.2012.4.5.264
The cockroach represents one of the most common sources of indoor allergens worldwide, and 40%-60% of patients with asthma in urban and inner-city areas possess IgE antibodies to cockroach allergens.... -
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- Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus
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Lee YJ, Hussain Z, Huh CW, Lee YJ, Park H
- KMID: 2417282
- J Neurogastroenterol Motil.
- 2018 Jan;24(1):147-158.
- doi: 10.5056/jnm17012
BACKGROUND/AIMS: Postoperative ileus (POI) is characterized by impaired propulsive function of the gastrointestinal tract after surgery. Although inflammation is considered to be an important pathogenesis of POI, significant data are... -
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- New Therapeutic Targets for Obesity Treatment in Basic Medical Science
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Lee SK
- KMID: 1437229
- Korean J Obes.
- 2012 Sep;21(3):125-131.
- doi: 10.7570/kjo.2012.21.3.125
Change in either energy intake or energy expenditure alone will meet resistance as compensatory adjustments occur, because body fat seems to be regulated homeostatically. Therefore, combined therapy targeting the multiple... -
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- Stress-induced Alterations in Mast Cell Numbers and Proteinase-activated Receptor-2 Expression of the Colon: Role of Corticotrophin-releasing Factor
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Kim DH, Cho YJ, Kim JH, Kim YB, Lee KJ
- KMID: 1785913
- J Korean Med Sci.
- 2010 Sep;25(9):1330-1335.
- doi: 10.3346/jkms.2010.25.9.1330
This study was performed in order to assess whether acute stress can increase mast cell and enterochromaffin (EC) cell numbers, and proteinase-activated receptor-2 (PAR2) expression in the rat colon. In... -
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- Protease-activated Receptor 2 is Associated with Activation of Human Macrophage Cell Line THP-1
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Kang CS, Tae J, Lee YM, Kim BS, Moon WS, Kim DK
- KMID: 1846705
- Immune Netw.
- 2005 Dec;5(4):193-198.
- doi: 10.4110/in.2005.5.4.193
BACKGROUND: Protease-activated receptor 2 (PAR2) belongs to a family of G protein- coupled receptors activated by proteolytic cleavage. Trypsin-like serine proteases interact with PAR2 expressed by a variety of tissues... -
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- Cloning and expression of trypsin-encoding cDNA from Blattella germanica and its possibility as an allergen
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Ock MS, Kim BJ, Kim SM, Byun KH
- KMID: 1720500
- Korean J Parasitol.
- 2005 Sep;43(3):101-110.
- doi: 10.3347/kjp.2005.43.3.101
In this study, the trypsin gene (bgtryp-1) from the German cockroach, Blattella germanica, was cloned via the immunoscreening of patients with allergies to cockroaches. Nucleotide sequence analysis predicted an 863... -
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- Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid
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Joo YA, Chung H, Yoon S, Park JI, Lee JE, Myung CH, Hwang JS
- KMID: 2351678
- Biomol Ther.
- 2016 Sep;24(5):529-535.
- doi: 10.4062/biomolther.2016.011
Atopic dermatitis (AD) results from gene and environment interactions that lead to a range of immunological abnormalities and breakdown of the skin barrier. Protease-activated receptor 2 (PAR2) belongs to a... -
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- Protease-Activated Receptors 2-Antagonist Suppresses Asthma by Inhibiting Reactive Oxygen Species-Thymic Stromal Lymphopoietin Inflammation and Epithelial Tight Junction Degradation
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Kim HJ, Lee SH, Jeong S, Hong SJ
- KMID: 2448758
- Allergy Asthma Immunol Res.
- 2019 Jul;11(4):560-571.
- doi: 10.4168/aair.2019.11.4.560
PURPOSE: Protease-activated receptor 2 (PAR2) reportedly triggers the immune response in allergic asthma. We aimed to investigate the mechanism on allergic inflammation mediated by PAR2. METHODS: Human lung epithelial cells (A549... -
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- Effect of Pertussis Toxin and Herbimycin A on Proteinase-Activated Receptor 2-Mediated Cyclooxygenase 2 Expression in Helicobacter pylori-Infected Gastric Epithelial AGS Cells
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Seo JH, Seo JY, Chung HY, Kim H
- KMID: 1777026
- Yonsei Med J.
- 2011 May;52(3):522-526.
- doi: 10.3349/ymj.2011.52.3.522
Helicobacter pylori (H. pylori) is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Proteinase-activated receptor 2 (PAR2), subgroup of G-protein coupled receptor family, is highly expressed... -
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- Protease-Activated Receptor 2 Is Involved in Th2 Responses against Trichinella spiralis Infection
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Park MK, Cho MK, Kang SA, Park HK, Kim YS, Kim KU, Ahn SC, Kim DH, Yu HS
- KMID: 1715646
- Korean J Parasitol.
- 2011 Sep;49(3):235-243.
- doi: 10.3347/kjp.2011.49.3.235
In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2... -
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