- Effects of Calcium and Potassium Channel Blockers on Local Anesthetics-Induced Relaxation in Rat Thoracic Aortic Rings
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Kim HG, Park SS, Park JW
- KMID: 1934355
- Korean J Anesthesiol.
- 1995 Mar;28(3):376-384.
- doi: 10.4097/kjae.1995.28.3.376
This study was designed to evaluate the effects of calcium and potassium channel blockers on local anesthetics-induced vascular relaxation of isolated rat thoracic aorta. In the presence of lidocaine and... -
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- Physiologic Role of K+ Channels in Relaxation of Rabbit Corpus Cavernosal Tissue
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Lee SI, Lee SW
- KMID: 1894493
- Korean J Androl.
- 2002 Dec;20(3):137-142.
PURPOSE: Ion channels play key roles in determining smooth muscle tone by setting the membrane potential and allowing Ca2+ influx. Potassium channels may be important in modulating corporal smooth muscle... -
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- Inhibitory Effects of Potassium Channel Blockers on Carbachol-induced Contraction in Rat Detrusor Muscle
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Oh SJ, Ahn SC
- KMID: 1130042
- J Korean Med Sci.
- 2003 Oct;18(5):701-706.
- doi: 10.3346/jkms.2003.18.5.701
We present accidental findings that potassium channel blockers, such as tetraethyl-ammonium (TEA) or 4-aminopyridine (4-AP), inhibit the sustained tonic contraction induced by carbachol in rat detrusor muscle strips. The relatively... -
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- Effects of Cisapride on Action Potential Duration and on ATP-Sensitive K Channel in Guinea Pig Ventricular Muscles
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Joo CU, Kim YJ, Mun SK, Chae SW
- KMID: 1748178
- J Korean Pediatr Soc.
- 1999 Jul;42(7):953-958.
PURPOSE: Cisapride(Prepulsid(R)) has been recently associated with long QT syndrome. It has been reported to cause Torsades de Pointes and induce early afterdepolarization in rabbit Purkinje fibers. We investigated the... -
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- 4-Aminopyridine Improves Lower Urinary Tract Symptoms in a Patient With Benign Prostatic Hyperplasia and Downbeat Nystagmus Syndrome
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Strupp M, Feil K, Bardins S, Waidelich
- KMID: 2232736
- Int Neurourol J.
- 2014 Dec;18(4):221-225.
- doi: 10.5213/inj.2014.18.4.221
Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders. Here we present a patient with... -
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- Influence of Potassium Channel Blockage on Early Hypoxic Neuronal Excitability
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Kim JH, Moon HJ, Kim JH, Kwon TH, Chung HS, Park YK
- KMID: 2106793
- J Korean Neurotraumatol Soc.
- 2010 Dec;6(2):97-105.
- doi: 10.13004/jknts.2010.6.2.97
OBJECTIVE: Potassium channels are ubiquitously expressed in all organisms and constitute the most diverse class of ion channels. Their action is regulated by various factors and is involved in neuronal... -
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- A Computational Model of the Temperature-dependent Changes in Firing Patterns in Aplysia Neurons
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Hyun NG, Hyun KH, Hyun KB, Han JH, Lee K, Kaang BK
- KMID: 2285424
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):371-382.
- doi: 10.4196/kjpp.2011.15.6.371
We performed experiments using Aplysia neurons to identify the mechanism underlying the changes in the firing patterns in response to temperature changes. When the temperature was gradually increased from 11degrees... -
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- Comparison of Purinergic and Cholinergic Receptor-Mediated Effects on Action Potential in Rat Atrium
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Cho BH, Kwak SH, Kim DY, Lee SY
- KMID: 2275076
- Chonnam Med J.
- 1995 Dec;31(2):175-185.
In the heart, it has been known that acetylcholine and adenosine produce similar negative inotropic effects protecting myocardial tissues from some overloaded states. However, the precise mechanism underlying the similarities... -
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- The Effect of ATP-sensitive Potassium Channel on R-PIA Induced Mechanical Antiallodynia in a Peripheral Neuropathic Rat
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Min HG, Seong SH, Jung SM, Shin JW, Gwak MJ, Leem JG, Lee C
- KMID: 2277971
- Korean J Pain.
- 2005 Dec;18(2):107-112.
- doi: 10.3344/kjp.2005.18.2.107
BACKGROUND: Nerve ligation injury may produce mechanical allodynia, but this can be reversed after an intrathecal administration of adenosine analogues. In many animal and human studies, ATP-sensitive potassium channel blockers... -
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- The Effect of Tetraethylammonium Chloride on the Impulse Conduction Block by bupivacaine
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Lee SJ, Kim BJ, Choi H, Lee SW, Kil HY, Yoon YJ
- KMID: 2236922
- Korean J Anesthesiol.
- 1994 Nov;27(11):1541-1550.
- doi: 10.4097/kjae.1994.27.11.1541
Potassium channel blockers slow depolarization, broaden the action potential, and thus pro- mote the open and inactivated Na+ channel states. The ability of local anesthetics to reduce the amplitude of... -
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- The Mechanism of R-PIA Induced Mechanical Antiallodynia in a Peripheral Neuropathic Rat
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Choi WJ, Kim YK, Shin EY, Shin JW, Sim JY, Leem JG, Lee C
- KMID: 1763287
- Korean J Anesthesiol.
- 2008 Apr;54(4):441-445.
- doi: 10.4097/kjae.2008.54.4.441
BACKGROUND: The injury by a nerve ligation produces a mechanical allodynia. The antiallodynic effect resulted from intrathecal administration of the adenosine analogues has been well known. ATP-sensitive potassium channel blockers... -
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- Effects of PCLS-2 in Regulation of Rabbit Corpus Cavernosum Smooth Muscle Tone
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Park JK, Kim JU, Cho KW, Lee SK, Kim YC, Lee HS
- KMID: 2292366
- Korean J Urol.
- 2001 Feb;42(2):159-165.
PURPOSE: Relaxation of the penile cavernosum smooth muscle is a critical event in erection. Artemisia iwaymogi(AI) is a perennial herb growing in Korea. The aerial parts have been used in... -
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- Regulation of Antiarrhythmic Drug Propafenone Effects on the C-type KV1.4 Potassium Channel by PHo and K+
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Wang Z, Wang S, Li J, Jiang X, Wang N
- KMID: 1794411
- J Korean Med Sci.
- 2009 Feb;24(1):84-91.
- doi: 10.3346/jkms.2009.24.1.84
The effects of the antiarrhythmic drug propafenone at c-type kv1.4 channels in Xenopus laevis oocytes were studied with the two-electrode voltage-clamp techinique. Defolliculated oocytes (stage V-VI) were injected with transcribed... -
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- Characteristics of Potassium and Calcium Currents of Hepatic Stellate Cells (Ito) in Rat
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Lee KI, Kong ID, Baik SK, Kim HS, Lee DK, Kwon SO, Chun BG
- KMID: 721416
- Yonsei Med J.
- 2004 Aug;45(4):649-660.
- doi: 10.3349/ymj.2004.45.4.649
Hepatic stellate cells (HSCs) are known to play a role in the pathogenesis of the increased intrahepatic vascular resistance found in chronic liver diseases. The aim of this study was... -
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- Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase
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Sung DJ, Noh HJ, Kim JG, Park SW, Kim B, Cho H, Bae YM
- KMID: 2154286
- Exp Mol Med.
- 2013 Dec;45(12):e67.
Serotonin (5-hydroxytryptamine (5-HT)) is a neurotransmitter that regulates a variety of functions in the nervous, gastrointestinal and cardiovascular systems. Despite such importance, 5-HT signaling pathways are not entirely clear. We... -
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- The Inhibitory Effects of Hydrogen Sulfide on Pacemaker Activity of Interstitial Cells of Cajal from Mouse Small Intestine
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Parajuli S, Choi S, Lee J, Kim YD, Park CG, Kim MY, Kim HI, Yeum CH, Jun JY
- KMID: 1457673
- Korean J Physiol Pharmacol.
- 2010 Apr;14(2):83-89.
- doi: 10.4196/kjpp.2010.14.2.83
In this study, we studied whether hydrogen sulfide (H2S) has an effect on the pacemaker activity of interstitial cells of Cajal (ICC), in the small intestine of mice. The actions... -
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- Sodium-activated Potassium Current in Guinea pig Gastric Myocytes
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Kim YC, Sim JH, Kang TM, Suzuki H, Kim SR, Kwon SC, Xu WX, Lee SJ, Kim KW
- KMID: 1713230
- J Korean Med Sci.
- 2007 Feb;22(1):57-62.
- doi: 10.3346/jkms.2007.22.1.57
This study was designed to identify and characterize Na+ -activated K+ current (I(K(Na))) in guinea pig gastric myocytes under whole-cell patch clamp. After whole-cell configuration was established under 110 mM... -
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- A Novel Pathway Underlying the Inhibitory Effects of Melatonin on Isolated Rat Urinary Bladder Contraction
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Han JH, Chang IH, Myung SC, Lee MY, Kim WY, Lee SY, Lee SY, Lee SW, Kim KD
- KMID: 2285438
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):37-42.
- doi: 10.4196/kjpp.2012.16.1.37
The aim of the present study was to elucidate the direct effects of melatonin on bladder activity and to determine the mechanisms responsible for the detrusor activity of melatonin in... -
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- Polyphenol (-)-Epigallocatechin Gallate during Ischemia Limits Infarct Size Via Mitochondrial K(ATP) Channel Activation in Isolated Rat Hearts
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Song DK, Jang Y, Kim JH, Chun KJ, Lee D, Xu Z
- KMID: 1778032
- J Korean Med Sci.
- 2010 Mar;25(3):380-386.
- doi: 10.3346/jkms.2010.25.3.380
Polyphenol (-)-epigallocatechin gallate (EGCG), the most abundant catechin of green tea, appears to attenuate myocardial ischemia/reperfusion injury. We investigated the involvement of ATP-sensitive potassium (K(ATP)) channels in EGCG-induced cardioprotection. Isolated... -
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- Inhibition of the Human Ether-a-go-go-related Gene (HERG) K+ Channels by Lindera erythrocarpa
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Hong HK, Yoon WJ, Kim YH, Yoo ES, Jo SH
- KMID: 1783138
- J Korean Med Sci.
- 2009 Dec;24(6):1089-1098.
- doi: 10.3346/jkms.2009.24.6.1089
Lindera erythrocarpa Makino (Lauraceae) is used as a traditional medicine for analgesic, antidote, and antibacterial purposes and shows anti-tumor activity. We studied the effects of Lindera erythrocarpa on the human... -
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