- Decreased IgE antibody formation in mice treated with polyadenyic pollyuridylic acid and polyinosinic polycytidylic acid
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Lee BK, Shin JS, Chu MK, Youn JK
- KMID: 1688105
- J Korean Soc Microbiol.
- 1993 Apr;28(2):165-174.
No abstract available. -
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- The Expression of TLR3 and Cytokines Induced by Poly I:C in Human Retinal Pigment Epithelial Cells
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Choi SJ, Kim J, Park SJ, Park HS, Lee KH, Kim SK, Park JY
- KMID: 1513585
- J Bacteriol Virol.
- 2007 Dec;37(4):241-248.
- doi: 10.4167/jbv.2007.37.4.241
In this study, we examined the expression of Toll-like receptor3 (TLR3) by human retinal pigment epithelial cells (RPE) and determined whether exposure to the TLR3 agonist polyinosinic-polycytidylic acid (poly I:C)... -
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- Mouse Model of IL-17-Dominant Rhinitis Using Polyinosinic-Polycytidylic Acid
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Bae JS, Kim EH, Kim JH, Mo JH
- KMID: 2421665
- Allergy Asthma Immunol Res.
- 2017 Nov;9(6):540-549.
- doi: 10.4168/aair.2017.9.6.540
Interleukin (IL)-17 plays an important role in rhinitis and the level thereof correlates with the severity of disease. However, no mouse model for IL-17-dominant rhinitis has yet been developed. Our... -
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- Effect of Polyinosinic-Polycytidylic Acid on MUC5B Expression in Human Airway Epithelial Cells
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Choi YH, Bae CH, Kim HG, Seo BH, Choi YS, Song SY, Kim YD
- KMID: 2063270
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2015 Sep;58(9):615-621.
- doi: 10.3342/kjorl-hns.2015.58.9.615
BACKGROUND AND OBJECTIVES: Polyinosinic-polycytidylic acid (Poly I:C) is structurally similar to double-stranded RNA, and is known to induce various inflammatory mediators and to cause inflammatory reactions in airway epithelial cells.... -
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- Induction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis
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Ryu DB, Lim JY, Lee SE, Park G, Min CK
- KMID: 2362800
- Immune Netw.
- 2016 Dec;16(6):358-365.
- doi: 10.4110/in.2016.16.6.358
Mesenchymal stem cells (MSCs) have been used experimentally for treating inflammatory disorders, partly owing to their immunosuppressive properties. The goal of the study was to determine whether TLR ligands can... -
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- Galangin Suppresses Pro-Inflammatory Gene Expression in Polyinosinic-Polycytidylic Acid-Stimulated Microglial Cells
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Choi MJ, Park JS, Park JE, Kim HS, Kim HS
- KMID: 2395814
- Biomol Ther.
- 2017 Nov;25(6):641-647.
- doi: 10.4062/biomolther.2017.173
Galangin (3,5,7-trihydroxyflavone) is a polyphenolic compound abundant in honey and medicinal herbs, such as Alpinia officinarum. In this study, we investigated the anti-inflammatory effects of galangin under in vitro and... -
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- Role of AMP-Activated Protein Kinase (AMPK) in Smoking-Induced Lung Inflammation and Emphysema
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Lee JS, Park SJ, Cho YS, Huh JW, Oh YM, Lee SD
- KMID: 2114643
- Tuberc Respir Dis.
- 2015 Jan;78(1):8-17.
- doi: 10.4046/trd.2015.78.1.8
BACKGROUND: AMP-activated protein kinase (AMPK) not only functions as an intracellular energy sensor and regulator, but is also a general sensor of oxidative stress. Furthermore, there is recent evidence that... -
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- Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells
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Zandieh Z, Amjadi F, Vakilian H, Aflatoonian K, Amirchaghmaghi E, Fazeli A, Aflatoonian R
- KMID: 2427410
- Clin Exp Reprod Med.
- 2018 Dec;45(4):154-162.
- doi: 10.5653/cerm.2018.45.4.154
OBJECTIVE: The fallopian tubes play a critical role in the early events of fertilization. The rapid innate immune defense is an important part of the fallopian tubes. Toll-like receptor 3... -
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- TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling
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Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M
- KMID: 2418847
- Yonsei Med J.
- 2018 Jan;59(1):43-50.
- doi: 10.3349/ymj.2018.59.1.43
PURPOSE: Tripartite-motif-containing protein 56 (TRIM56) has been found to exhibit a broad antiviral activity, depending upon E3 ligase activity. Here, we attempted to evaluate the function of TRIM56 in multiple... -
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- Protective Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine Against Lipopolysaccharide or Polyinosinic-polycytidylic Acid-induced Acute Hepatotoxicity
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Lee SY, Ko KS
- KMID: 2367573
- J Cancer Prev.
- 2016 Sep;21(3):152-163.
- doi: 10.15430/JCP.2016.21.3.152
BACKGROUND: Several mechanisms for the pathogenesis of many liver diseases are related with oxidative stress, endotoxins, and infections by many microorganisms. These can lead to chronic hepatitis, cirrhosis, and even... -
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- Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts
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Park MK, Oh HJ, Heo YM, Park EM, Cho ML, Kim HY, Park SH
- KMID: 1022119
- Exp Mol Med.
- 2011 Aug;43(8):446-454.
- doi: 10.3858/emm.2011.43.8.050
Indoleamine 2,3-dioxygenase (IDO) is a key negative regulator of immune responses and has been implicated in tumor tolerance, autoimmune disease and asthma. IDO was detected in the joint synovial tissue... -
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- Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types
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Kim JJ, Kim KS, Eom J, Lee JB, Seo JY
- KMID: 2461197
- Immune Netw.
- 2019 Oct;19(5):e33.
- doi: 10.4110/in.2019.19.e33
Viperin is an IFN-stimulated gene (ISG)-encoded protein that was identified in human primary macrophages treated with IFN-γ and in human primary fibroblasts infected with cytomegalovirus (CMV). This protein plays multiple... -
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