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Circulating Tumor Cells: Detection Methods and Potential Clinical Application in Breast Cancer

Kim SI, Jung HI

Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients. CTCs have long been regarded as an attractive research topic. Because of recent technological...
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Circulating Tumor Cells and Extracellular Nucleic Acids in Breast Cancer

Ryu DW, Lee CH

Circulating tumor cells (CTCs) are defined as tumor cells circulating in the peripheral blood of patients, shed from either the primary tumor or from its metastases. The detection of circulating...
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Circulating Tumor Cells in Lung Cancer

Yang SH, Yang YS

Circulating Tumour Cells (CTCs) can be released from the primary lung tumour into the bloodstream and they may colonize distant organs and give rise to metastasis. The presence of CTCs...
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Circulating Tumor Cell and Cell-free Circulating Tumor DNA in Lung Cancer

Nurwidya F, Zaini J, Putra AC, Andarini S, Hudoyo A, Syahruddin E, Yunus F

Circulating tumor cells (CTCs) are tumor cells that are separated from the primary site or metastatic lesion and disseminate in blood circulation. CTCs are considered to be part of the...
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Translational Application of Single-cell Transcriptomic Analysis in Hepatocellular Carcinoma

Yoon SK

The emergence of single-cell technology in recent years has made remarkable progress for understanding of biological process in various diseases including cancers. In particular of cancer, single-cell transcriptome analysis provides...
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Clinical Significance of Circulating Tumor Cells in Gastric Cancer

Jeon HK, Kim GH

Cancer specimens obtained via surgical resection or biopsy are generally used to understand tumor-associated alterations; however, those approaches cannot always be performed because of their invasive nature, and they may...
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Circulating Aneuploid Cells Detected in the Blood of Patients with Infectious Lung Diseases

Kim H, Cho JH, Sonn CH, Kim JW, Choi Y, Lee J, Kim J

The identification of circulating tumor cells (CTCs) is clinically important for diagnosing cancer. We have previously developed a size-based filtration platform followed by epithelial cell adhesion molecule immunofluorescence staining for...
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Current Methods of Circulating Tumor Cell Detection

Lim M, Cho YK

Liquid biopsy, the analysis of circulating biomarkers from peripheral blood, such as circulating tumor cells (CTCs) and circulating tumor DNA, and exosomes, offers a less invasive, new source of cancer-derived...
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An Unusual Case of Ovarian Carcinomatosis with Microscopic Tumor Embolism Leading to Rectal Ischemia and Perforation

Tang MH, Lim J, Bushmani I, Ng CY

We present an unusual case of advanced ovarian carcinoma with postoperative complications of ischemia and perforation of the rectum as a result of tumor embolism. The interval progression from ischemia...
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Role of β₁-Integrin in Colorectal Cancer: Case-Control Study

Oh BY, Kim KH, Chung SS, Hong KS, Lee RA

OBJECTIVES: In the metastatic process, interactions between circulating tumor cells (CTCs) and the extracellular matrix or surrounding cells are required. β1-integrin may mediate these interactions. The aim of this study...
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Simultaneous Detection of Disseminated and Circulating Tumor Cells in Primary Breast Cancer Patients

Hartkopf A, Wallwiener M, Hahn M, Fehm TN, Brucker SY, Taran FA

PURPOSE: Disseminated tumor cells (DTCs) from bone marrow (BM) are a surrogate of minimal residual disease (MRD) in primary breast cancer (PBC) patients and associated with an adverse prognosis. However,...
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Clinical Application of Circulating Tumor Cells in Gastric Cancer

Lee MW, Kim GH, Jeon HK, Park SJ

Early detection and accurate monitoring of cancer is important for improving clinical outcomes. Endoscopic biopsy and/or surgical resection specimens are the gold standard for diagnosing gastric cancer and are also...
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Circulating Tumor Cell Number Is Associated with Primary Tumor Volume in Patients with Lung Adenocarcinoma

Kang BJ, Ra SW, Lee K, Lim S, Son SH, Ahn JJ, Kim BC

BACKGROUND: Circulating tumor cells (CTCs) are frequently detected in patients with advanced-stage malignant tumors and could act as a predictor of poor prognosis. However, there is a paucity of data...
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Circulating Tumor Cells: Liquid Biopsy for Early Detection of Cancer

Mwesige B, Yeo SG, Yoo BC

Cancer is a complex, heterogeneic, and dynamic disease involving multiple gene-environment interactions, and affecting numerous biological pathways. As such, the development of reliable and robust non-invasive platforms constitutes a vital...
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A New Cell Block Method for Multiple Immunohistochemical Analysis of Circulating Tumor Cells in Patients with Liver Cancer

Nam SJ, Yeo HY, Chang HJ, Kim BH, Hong EK, Park JW

PURPOSE: We developed a new method of detecting circulating tumor cells (CTCs) in liver cancer patients by constructing cell blocks from peripheral blood cells, including CTCs, followed by multiple immunohistochemical...
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Current Status of the Use of Salvaged Blood in Metastatic Spine Tumour Surgery

Kumar N, Ravikumar , Tan JY, Akbary K, Patel RS, Kannan R

To review the current status of salvaged blood transfusion (SBT) in metastatic spine tumour surgery (MSTS), with regard to its safety and efficacy, contraindications, and adverse effects. We also aimed...
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Liquid Biopsy: Current Status and Future Perspective in Gastric Cancer and Helicobacter Infection

Kang EA, Han YM, Park JM, Yoo IK, Hong SP, Hahm KB

Precision medicine stands for 4Ps - precise, preventive, participatory, and personal; in which “precision” is important because the current modern medicine starts from “trial and error,” and “one does not...
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Influence of surgical manipulation and surgical modality on the molecular detection of circulating tumor cells from colorectal cancer

Park SY, Choi GS, Park JS, Kim HJ, Ryuk JP, Choi WH

  • KMID: 2324835
  • J Korean Surg Soc.
  • 2012 Jun;82(6):356-364.
PURPOSE: The aim of this study was to evaluate the relationship between the detection of circulating tumor cell molecular markers from localized colorectal cancer and the time-course of a surgical...
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Identification of Enhancer of Zeste Homolog 2 Expression in Peripheral Circulating Tumor Cells in Metastatic Prostate Cancer Patients: A Preliminary Study

Cho KS, Oh HY, Lee EJ, Hong SJ

PURPOSE: Enhancer of zeste homolog 2 (EZH2), a kind of transcriptional repressor, is reportedly over-expressed in metastatic prostate cancer. In this study, we analyzed EZH2 mRNA in circulating tumor...
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Bone Marrow Involvement of Primary Mediastinal Germ Cell Tumor: A Case Report

Lim JG, Lee MK, Choi JR, Park Q, Song KS, Yang CH

  • KMID: 2031031
  • Korean J Clin Pathol.
  • 1999 Oct;19(5):496-499.
A variety of solid tumors can metastasize to bone marrow. In rare cases actual circulating neoplastic cells can be identified, accounting for usually only a low proportion of total white...
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