J Liver Cancer.  2018 Mar;18(1):1-8. 10.17998/jlc.18.1.1.

Translational Application of Single-cell Transcriptomic Analysis in Hepatocellular Carcinoma

• Yoon SK

• KMID: 2409642
• DOI: http://doi.org/10.17998/jlc.18.1.1

Abstract

The emergence of single-cell technology in recent years has made remarkable progress for understanding of biological process in various diseases including cancers. In particular of cancer, single-cell transcriptome analysis provides a powerful tool for comprehensive characterization of cancer cell subpopulations within a heterogeneous bulk populations. Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer and its molecular mechanism is extremely complex associated with a poor prognosis. To date, the molecular mechanisms of hepatocarcinogenesis remain unclear. Here, I review current status of single-cell transcriptome analysis for HCC, focusing on their application for cancer genomics, circulating tumor cells, cancer stem cells and tumor infiltrating cells in HCC.

Keyword

Sequencing; Hepatocellular carcinoma; Transcriptome; RNA sequencing; Circulating tumor cells

MeSH Terms

Biological Processes
Carcinoma, Hepatocellular*
Gene Expression Profiling
Genomics
Neoplastic Cells, Circulating
Neoplastic Stem Cells
Prognosis
Sequence Analysis, RNA
Transcriptome