Neurospine.  2018 Sep;15(3):206-215. 10.14245/ns.1836140.070.

Current Status of the Use of Salvaged Blood in Metastatic Spine Tumour Surgery

• Kumar N
• Ravikumar
• Tan JY
• Akbary K
• Patel RS
• Kannan R

• KMID: 2426306
• DOI: http://doi.org/10.14245/ns.1836140.070

Abstract

To review the current status of salvaged blood transfusion (SBT) in metastatic spine tumour surgery (MSTS), with regard to its safety and efficacy, contraindications, and adverse effects. We also aimed to establish that the safety and adverse event profile of SBT is comparable and at least equal to that of allogeneic blood transfusion. MEDLINE and Scopus were used to search for relevant articles, based on keywords such as "cancer surgery,""salvaged blood," and "circulating tumor cells." We found 159 articles, of which 55 were relevant; 20 of those were excluded because they used other blood conservation techniques in addition to cell salvage. Five articles were manually selected from reference lists. In total, 40 articles were reviewed. There is sufficient evidence of the clinical safety of using salvaged blood in oncological surgery. SBT decreases the risk of postoperative infections and tumour recurrence. However, there are some limitations regarding its clinical applications, as it cannot be employed in cases of sepsis. In this review, we established that earlier studies supported the use of salvaged blood from a cell saver in conjunction with a leukocyte depletion filter (LDF). Furthermore, we highlight the recent emergence of sufficient evidence supporting the use of intraoperative cell salvage without an LDF in MSTS.

Keyword

Cancer surgery; Metastatic cancer surgery; Intraoperative cell salvage; Autologous salvaged blood; Circulating neoplastic cells; Metastatic spine tumour surgery

MeSH Terms

Blood Transfusion
Leukocytes
Neoplastic Cells, Circulating
Recurrence
Sepsis
Spine*