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A comprehensive review of hypertrophic cardiomyopathy and arterial thromboembolism in cats

Han D, Jung DI

The number of cats requiring treatment for hypertrophic cardiomyopathy (HCM) and arterial thromboembolism (ATE) continues to increase, and the knowledge regarding its management is constantly evolving. The pathological lesions of...
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Duodenoduodenal Intussusception due to a Migrated Percutaneous Radiologic Gastrostomy Tube: A Case Report

Hong JW, Kim SH, Yoon JA, Shin MJ, Shin YB

Patients with dysphagia often have difficulty in supplying adequate nutrition orally, and thus they often use gastrostomy for nutrition support. If the nutrition affects the deterioration of the disease, as...
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Motor dominant polyradiculopathy with Primary Sjögren's syndrome mimicking motor neuron disease

Ahn SW, Yoon BN

Sjögren's syndrome (SS)-associated polyradiculopathy is rarely reported. A 51-year-old woman presented with a history of gradual weakness in all four extremities for several months. Based on electrophysiological studies, spinal magnetic...
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Unilateral Hypoglossal Neuropathy in Multifocal Acquired Demyelinating Sensory and Motor Neuropathy: Differential Diagnosis of Motor Neuron Disease

Yoo SK, Kim MO, Kim CH, Kim YS, Kim SK, Kang H, Choi NC, Kwon OY, Lim BH, Park KH

Multifocal acquired demyelinating sensory and motor neuropathy (MADSAM) is a peripheral neuropathy characterized by multifocal weakness and associated sensory impairment. MADSAM is associated with multifocal persistent conduction block and other...
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Multifocal Motor Neuropathy: Complementary Role of Ultrasound

Rha HJ, Seok JI, Lee SR

Multifocal motor neuropathy (MMN) is an uncommon, asymmetric motor neuropathy. As MMN is a treatable disorder, its differentiation from lower motor neuron disease is important. Evidence of conduction block (CB)...
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Applicability of the digital instrument to improve the reproducibility of motor unit number index

Ahn SW

BACKGROUND: The motor unit number index (MUNIX) and motor unit size index (MUSIX) refer to the electrophysiological measurement of the motor units using the surface electromyographic interference pattern (SIP) recorded...
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The Clinical Utility of the Autoimmune Target Test for Neurologic Disease

Kim SH, Jearn LH, Kim TY

BACKGROUND: Many studies have reported the association between several anti-neuronal antibodies and neurologic diseases. However, there is no useful autoantibody screening test for neurologic diseases unlike the antinuclear antibody test...
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Percutaneous Endoscopic Gastrostomy Tube Insertion in Neurodegenerative Disease: A Retrospective Study and Literature Review

Sarkar P, Cole A, Scolding N, Rice CM

BACKGROUND/AIMS: With the notable exceptions of dementia, stroke, and motor neuron disease, relatively little is known about the safety and utility of percutaneous endoscopic gastrostomy (PEG) tube insertion in patients...
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Motor Neuron Disease Presenting With Acute Respiratory Failure: A Case Study

Oh H, Kang SW, Choi WA, Lee JW, Suh M, Kim EY

Motor neuron diseases (MNDs) refer to a heterogeneous group of progressive neurologic disorders caused by degeneration of motor neurons. The diseases affect either the upper motor neurons, lower motor neurons,...
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Normal data on axonal excitability in Koreans

Lee JY, Yu JH, Pyun SY, Ryu S, Bae JS

BACKGROUND: Automated nerve excitability testing is used to assess various peripheral neuropathies and motor neuron diseases. Comparing these excitability parameters with normal data provides information regarding the axonal excitability properties...
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Clinical Experiences of Uncommon Motor Neuron Disease: Hirayama Disease

Lee KH, Choi DS, Lee YS, Kang DH

Hirayama disease, juvenile muscular atrophy of the distal upper limb, is a rare disease predominantly affecting the anterior horn cells of the cervical spinal cord in young men. This cervical...
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Frontotemporal Dementia with Motor Neuron Disease in a Patient with Antiphospholipid Syndrome: A Case Report

Jeong YC, Park JS, Kim SH, Choi H

BACKGROUND: Frontotemporal dementia (FTD) with motor neuron disease (MND) is a syndrome of progressive changes in behavior, language, muscle weakness and atrophy due to loss of function of neurons in...
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Rapid Progression of Sporadic ALS in a Patient Carrying SOD1 p.Gly13Arg Mutation

Kim MJ, Bae JH, Kim JM, Kim HR, Yoon BN, Sung JJ, Ahn SW

Amyotrophic lateral sclerosis (ALS), the most common adult onset motor neuron disease, is pathologically characterized by progressive loss of the upper and lower motor neurons. Mutations in the Cu/Zn superoxide...
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An Autopsy Case of Frontotemporal Dementia with Motor Neuron Disease

Kim EJ, Oh EH, Kim KT, Jung Y, Lee JH, Lee JH, Lee YM, Kim SJ, Shin JH, Shin MJ, Lee MJ, Ahn JW, Sung S, Choi KU, Jung DS, Seeley WW, Huh GY

Approximately 15% of patients with frontotemporal dementia (FTD) have co-occurring motor neuron disease (MND). FTD-MND cases have frontotemporal lobar degeneration (FTLD)-transactive response DNA-binding protein (TDP) pathology, which is divided into...
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Update of Therapeutic Clinical Trials for Amyotrophic Lateral Sclerosis

Kim NH, Lee MO

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by progressive death of motor neurons in the cortex, brainstem, and spinal cord. Until now, many treatment strategies...
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Surgical Treatment in Cervical Myelopathy Combined with Flail Arm Syndrome

Son ES, Lim JG, Kim DH, Lee SJ

Flail arm syndrome (FAS) is a variant of the amyotrophic lateral sclerosis also known as Lou Gehrig's disease. FAS is a kind of motor neuron disease that represents a bilateral...
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Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?

Lee S, Kim HJ

ALS is a fatal adult-onset motor neuron disease. Motor neurons in the cortex, brain stem and spinal cord gradually degenerate in ALS patients, and most ALS patients die within 3~5...
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Concomitant Acute Transverse Myelitis and Sensory Motor Axonal Polyneuropathy in Two Children: Two Case Reports

Chung H, Joa KL, Kim HS, Kim CH, Jung HY, Kim MO

Acute transverse myelitis (ATM) is an upper motor neuron disease of the spinal cord, and concomitant association of peripheral polyneuropathy, particularly the axonal type, is rarely reported in children. Our...
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Severe Spinal Injury in Hirayama Disease

Quarracino C, Aguirre F, Rugilo CA, Negri LD, Villa AM

Hirayama disease is a rare neurological disorder characterized by an insidious progressive subacute unilateral or bilateral weakness of the hands and forearm muscles leading to a painless amyotrophy. The disease...
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Cerebral Infarction Presenting with Unilateral Isolated Foot Drop

Kim KW, Park JS, Koh EJ, Lee JM

Weakness of the dorsiflexor muscles of the ankle or toe, referred to as foot drop, is a relatively common presentation. In most cases, foot drop is caused by a lower...
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