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Prolonged Regional Anesthesia with Lidocaine Microspheres by Using a Biodegradable Polymer

Lim JO, Park SS, Baek WY

BACKGROUND: Biodegradable microspheres are a useful method of drug delivery because they are both injectable and biodegradable. Previous work in our group has characterized implantable preparations of local anesthetics in...
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Biodegradable poly (lactic acid) microspheres for drug delivery systems

Hyon SH

In connection with aim of maximizing the bio-availability of conventional drugs with minimum side-effects, new drug delivery systems (DDS) continue to attracted much attention. The controlled or sustained release of...
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Porous Microcarrier-Enabled Three-Dimensional Culture of Chondrocytes for Cartilage Engineering: A Feasibility Study

Jin GZ, Kim HW

Cartilage repair is substantially intractable due to poor self-healing ability. Porous microspheres can be a fascinating three-dimensional matrix for cell culture and injectable carrier in cartilage engineering. In this study,...
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Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats

Yang F, Kang J, Yang F, Zhao Z, Kong T, Zeng Z

New enrofloxacin microspheres were formulated, and their physical properties, lung-targeting ability, and tissue distribution in rats were examined. The microspheres had a regular and round shape. The mean diameter was...
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Two Cases of Linear Scleroderma 'En Coup de Sabre' Treated with Polymethylmethacrylate Microspheres (PMMA-NewPlastic(R))

Park JH, Oh DJ, Kang SH, Hwang SW, Cho SH, Park SW

  • KMID: 1639699
  • Korean J Dermatol.
  • 2006 Apr;44(4):512-514.
Localized scleroderma is a disease of unknown origin and is characterized by circumscribed sclerotic skin changes. When occurring in a linear pattern, it is called linear scleroderma. 'En coup de...
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Effects of Bone Density as Injections of Salmon Calcitonin Micropheres in Ovariectomized Rats

Han SH, Choi JW, Choi KS, Park SB, Lee SG, Paik DJ, Kim MJ

  • KMID: 2178727
  • J Korean Acad Rehabil Med.
  • 2003 Feb;27(1):121-125.
OBJECTIVE: This study was evaluated the bone protective effects of the salmon calcitonin microspheres against the cancellous bone loss in the ovariectomized rats. METHOD: The experimented rats were total 50...
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Phagocytic Function of Retinal Pigment Epithelial Cells toLatex Microspheres in Rabbit :Ultrastructural Findings

Park JS, Ko MK, Kim JG

  • KMID: 2205563
  • J Korean Ophthalmol Soc.
  • 1999 Sep;40(9):2495-2500.
Phagocytosis and morphologic changes in the retinal pigment epithelial cell (RPE) were observed after subretinal injection of latex microspheres. Latex microspheres were injected into the subretinal space in the posterior...
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Clinical application and histologic finding of pmma(polymethyl metacrylate) microspheres

No authors listed

  • KMID: 2204103
  • J Korean Soc Plast Reconstr Surg.
  • 1998 Oct;25(7):1251-1257.
Many attempts have been made to correct wrinkles or scar artificial or biological materials during the past decades. However artificial implants(fluid silicone, bioplastique, collagen) might be appeared in the form...
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Development of Gentamicin Loaded PLGA Microspheres for the Treatment of Musculoskeletal Infection: In Vivo Evaluation

Kim YS, Cho JC, Yun DI, Khang G, Rhee JM, Yoon SJ, Lee HB, Song JM

  • KMID: 1828533
  • J Korean Orthop Res Soc.
  • 2001 Oct;4(2):96-104.
PURPOSE: We evaluate in vitro and in vivo efficacy of newly developed gentamicin loaded PLGA microspheres for the treatment of musculoskeletal infection. MATERIALS AND METHODS: Controlled gentamicin sulfate releasing microspheres...
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Effect of Drug Carrier Melting Points on Drug Release of Dexamethasone-Loaded Microspheres

Park JH, Kwon DY, Heo JY, Park SH, Park JY, Lee B, Kim JH, Kim MS

Here, we examined the effect of melting point of drug carriers on drug release of dexamethasone (Dex)-loaded microspheres. We prepared poly(L-lactide-ran-ε-caprolactone) (PLC) copolymers with varying compositions of poly(εcaprolactone) (PCL) and...
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Two Cases of Unresectable Cholangiocarcinoma Treated by Yttrium-90 Microspheres

You SH, Kim YH, Cho SB, Ganbold U, Um SH, Seo YS, Choe JG

Intrahepatic cholangiocarcinoma (ICC) is a rare malignancy and many cases of ICCs are diagnosed in an unresectable state. Until now there has been no effective palliative treatment for these cases....
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Optimization of Recombinant Human Platelet-Derived Growth Factor-BB Encapsulated in Poly (Lactic-co-Glycolic Acid) Microspheres for Applications in Wound Healing

Bae YJ, Cho CH, Lee WJ, Huh JS, Lim JO

Growth factors play multiple and critical roles in wound repair processes. Platelet-derived growth factor (PDGF) is a potent growth factor that is particularly important in the early inflammatory phase of...
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Update on Transarterial Chemoembolization with Drug-Eluting Microspheres for Hepatocellular Carcinoma

Nouri YM, Kim JH, Yoon HK, Ko HK, Shin JH, Gwon DI

Conventional transcatheter arterial chemoembolization (c-TACE) is a widely used first-line palliative treatment for patients with unresectable hepatocellular carcinoma (HCC). Despite the effectiveness of c-TACE, to date, technique and procedure scheduling...
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Yttrium-90 Selective Internal Radiation Therapy with Glass Microspheres for Hepatocellular Carcinoma: Current and Updated Literature Review

Lee EW, Alanis L, Cho SK, Saab S

Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage,...
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Gastrectomy for the treatment of refractory gastric ulceration after radioembolization with 90Y microspheres

Yim SY, Kim JD, Jung JY, Kim CH, Seo YS, Yim HJ, Um SH, Ryu HS, Kim YH, Kim CS, Shin E

Transcatheter arterial radioembolization (TARE) with Yttrium-90 (90Y)-labeled microspheres has an emerging role in treatment of patients with unresectable hepatocellular carcinoma. Although complication of TARE can be minimized by aggressive pre-evaluation...
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Facial Foreign Body Granuloma Caused by Filler (Artecoll(R)) Injection

Kim YJ, Park MY, Kim YC

  • KMID: 2302049
  • Korean J Dermatol.
  • 2008 Apr;46(4):491-493.
Artecoll(R) is a recently developed permanent synthetic cosmetic filler substance, composed of 75% bovine collagen and 25% polymethylmetacrylate (PMMA) microspheres of 30~40micrometer in diameter. It is used for the augmentation...
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Enhancement of Antigen-specific Antibody and CD8(+) T Cell Responses by Codelivery of IL-12-encapsulated Microspheres in Protein and Peptide Vaccination

Park SH, Chang J, Yang SH, Kim HJ, Kwak HH, Kim BM, Lee SH

BACKGROUND: Although IL-12 has been widely accepted to play a central role in the control of pathogen infection, the use of recombinant IL-12 (rIL-12) as a vaccine adjuvant has been...
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PMMA microspheres (ARTECOLL(R)) injection for nasal ridge augmentation in the orthognathic surgery

Ok YJ, Kim MJ, Paeng JY, Myoung H, Hwang SJ, Choi JY, Lee JH, Choung PH

  • KMID: 1575790
  • J Korean Assoc Oral Maxillofac Surg.
  • 2005 Aug;31(4):329-334.
Polymethyl-methacrylate(PMMA; Artecoll(R)) microspheres suspended 1 : 3 in a 3.5% collagen solution has been used as an injectable implant for long lasting correction of wrinkles and minor skin defects....
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Degradable Gelatin Microspheres as an Embolic Agent: an Experimental Study in a Rabbit Renal Model

Ohta S, Nitta N, Takahashi , Murata K, Tabata Y

OBJECTIVE: To investigate the basic characteristics of degradable gelatin microspheres (GMSs), including their embolic behavior and degradation periods when they are used as embolic materials in the renal arteries of...
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The Effect of Distal Aortic Pressure on Spinal Cord Perfusion in Rats

Park SM, Cho SJ, Ryu SM, Lee KH, Kang G

BACKGROUND: Aortic cross clamping is associated with spinal cord ischemia. This study used a rat spinal cord ischemia model to investigate the effect of distal aortic pressure on spinal cord...
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