J Korean Soc Plast Reconstr Surg.  1998 Oct;25(7):1251-1257.

Clinical application and histologic finding of pmma(polymethyl metacrylate) microspheres

• No authors listed

Abstract

Many attempts have been made to correct wrinkles or scar artificial or biological materials during the past decades. However artificial implants(fluid silicone, bioplastique, collagen) might be appeared in the form of dislocation, granuloma formation, or late allergic reaction many years later. Biological materials (bone, tendons, cartilage, fat) tend to be resorbed, and same injections are repeated. Recently, PMMA microspheres (Artecoll) have been applied to correct deep glabellar frowns, wrinkles, and scar. Artecoll is an injectable implant for the long-lasting correction of wrinkles and the other irregular surfaces. We obtained specimens of Artecoll for histopathology which injected in the upper for the correction of triple fold deformity. As a results, the histological findings of imbedded PMNA microspheres resemble that of fat cell closely and showed capsule formation around Artecoll compartments. Each microsphere was covered with collagen fibers, so that the distance between microspheres was decreased. The volume of monocytes seemed to diminish, and the active fibrosis seemed to end. Vascularization was complete and the number of foreign body cells decreased to a stable amount. No evidence of significant degradation of PMMA in our specimens was found. With above findings, we think that PMMA microsphere is a stable and reliable implant for soft tissue augmentation.

MeSH Terms

Adipocytes
Cartilage
Cicatrix
Collagen
Congenital Abnormalities
Dislocations
Fibrosis
Foreign Bodies
Granuloma
Hypersensitivity
Microspheres*
Monocytes
Polymethyl Methacrylate
Silicones
Tendons
Collagen
Polymethyl Methacrylate
Silicones