- Effect of Thalidomide on the Angiogenesis and In vivo Growth of Hepatoma Cells in the Mouse
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Kim JW, Lee HS, Yoon JH, Kim CY
- KMID: 2304611
- Korean J Gastroenterol.
- 2000 Aug;36(2):235-244.
BACKGROUND/AIMS: Thalidomide shows an antiangiogenic effect after metabolic activation in the rabbit, but the antiangiogenic effect in the mouse has not been established. This study was aimed to know if... -
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- Postnatal Development of Activities of MFO in Hepatic Microsomes from Rats Treated with Alcohol
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Kim KH
- KMID: 2052641
- Ewha Med J.
- 1991 Sep;14(3):223-228.
- doi: 10.12771/emj.1991.14.3.223
General concepts of hepatic drug-metabolizing enzymes in liver microsomes and the characteristics of induction of the enzyme are well known in adult rats. However there are few detailed reports on... -
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- ATPase Activity of Microsomes Prepared from Helicobacter pylori
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Hong WS, Jung HY, Yang SG, Myung SJ, Kim JH, Min YI, Jo HJ, Sa GJ, Park SP, Kim HW
- KMID: 1572034
- Korean J Gastroenterol.
- 2000 Dec;36(6):728-735.
No Abstract Available. -
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- Effect of Thiamine Deficiency on Drug Hydroxylation and Level of Cytochrome P-450 in the Rats
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Kim BH, Hong YS, Sung NE
- KMID: 1969656
- Ewha Med J.
- 1979 Dec;2(4):195-199.
- doi: 10.12771/emj.1979.2.4.195
Our studies are concerned with cytochrome P-450 content and 2-acetylaminofluorene N-and ring-hydroxylation by thiamine deficient rat liver microsomes. Incubation medium contained 100mM HEPES buffer pH 7.8, 2mM NADPH, 100mM KF,... -
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- Inhibitory Effects of 6-Gingerol on Cytochrome P450 in Human Liver Microsomes
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Joo SY, Lim YC
- KMID: 2334469
- J Korean Soc Clin Pharmacol Ther.
- 2011 Jun;19(1):52-58.
No abstract available. -
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- The Effects of Vitamin Antioxidants on Lipid Peroxidation in Rat Liver Microsomes
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Ham YA, Hong YS, Sung NE
- KMID: 1969220
- Ewha Med J.
- 1982 Sep;5(3):109-116.
- doi: 10.12771/emj.1982.5.3.109
We observed the effect of the administration of vitamin A,C and E with beta-naphthoflavone and piperonyl butoxide on cytochrome P-450 level and lipid peroxidation in rats liver. The level of... -
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- Study on Mixed Function and Lipid Peroxidation of Neonatal Hepatic Microsomes after Exposure to Alcohol During the Fetal and Lactating Period
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Hong YS, Ham YA, Lee HL
- KMID: 1965786
- Ewha Med J.
- 1989 Sep;12(3):145-150.
- doi: 10.12771/emj.1989.12.3.145
Maternal ingestion of alcohol produce not only change of drug metabolism but also proliferation of hepatic smooth endoplasmic reticulum and many developmental defects of the central nervous system. The present investigation... -
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- Effect of Various Anesthetics on the Hepatic Microsomal Cytochrome System and the Lipid Contents of Albino Rats
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Lee YJ, Sung NE
- KMID: 1969223
- Ewha Med J.
- 1982 Sep;5(3):147-163.
- doi: 10.12771/emj.1982.5.3.147
The cytochrome enzyme system of hepatic microsomes is important because of its versatility, being capable of catalysing the hydroxylation as well as other modifications of variety of lipids and foreign... -
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- The Effect of Phenobarbital on the Monooxygenase System in the Liver Microsomes of Neonatal, Immature and Adult Rats
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Hong YS, Lee JS
- KMID: 2052626
- Ewha Med J.
- 1988 Sep;11(3):131-142.
- doi: 10.12771/emj.1988.11.3.131
A variety of compounds including drugs, carcinogens, steroids and fatty acids are metabolized by microsomal monooxygenase system in the liver. The effect of phenobarbital(PB) on the monooxygenase system in the... -
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- Enhancement of O-dealkylation in Mouse Liver by Dietary Administrations of BHA and BHT: Studies with Isolated Perfused Livers and Hepatic Microsomes
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Ji SC, Conway JG, Thurman RG, Cha YN
- KMID: 693021
- Yonsei Med J.
- 1986 Jun;27(2):106-113.
- doi: 10.3349/ymj.1986.27.2.106
Effects of feeding 2(3)-tert-butyl 4-hydroxyanisole (BHA) and 3, 5-di-tert-butyl 4-hydroxytoluene (BHT) on the rates of mixed function oxidation and conjugation enzyme reactions have been determined using isolated hepatic microsomal fractions... -
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- The Effects of Vitamin A and E on Lipid Peroxidation in Ethanol Administered Rat Liver Microsomes
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Hong YS, Ham YA, Sung NE
- KMID: 2052611
- Ewha Med J.
- 1984 Mar;7(1):3-7.
- doi: 10.12771/emj.1984.7.1.3
Ethanol enhances the activity of microsomal enzyme system and lipid peroxidation. We observed the effect of chronic ethanol administration on cytochrome P-450 level and lipid peroxidation in rat liver microsome.... -
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- Induction of Hepatic Microsomal Cytochrome P450 by Styrene in Rat
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Kim KW, Chang SK, Joung HS, Lee JY, Moon YH, Park SS
- KMID: 1529816
- Korean J Occup Environ Med.
- 1997 Dec;9(4):604-613.
The effects of styrene on the induction of cytochrome P-450s (P450), (P4501A1/2, P4502B1/2 and P4502El) and activities of other related enzymes were investigated in the male Sprague Dawley rats which... -
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- Studies on the Hepatic Microsomal Mixed Function Oxidase System with Higenamine on the Rat
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Hong YS, Pae YS, Sung NE
- KMID: 1965658
- Ewha Med J.
- 1985 Sep;8(3):165-170.
- doi: 10.12771/emj.1985.8.3.165
The effect of intraperitonelly administered higenamine on the cytochrome P -450, b5, P-nitroanisole-O-demethylase and lipid peroxidation in the rat hepatic microsomes were determined. The following results were obtained ; 1)... -
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- Comparison of the Glucurinidation Ability of Liver Microsomes from Rats Treated with Alcohol
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Kim KH
- KMID: 1965224
- Ewha Med J.
- 1990 Sep;13(3):149-155.
- doi: 10.12771/emj.1990.13.3.149
Glucuronidation is low or undectable in embryonic and early fetal tissues and changes to adult levels at rates depending on the acceptor, tissue and species. The present investigation examined the effects... -
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- Effect of Pyroligneous Liquor on Oxygen Radicals and Their Scavenger Enzymes in Liver of CD Rats
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Cho WK, Choi JH
- KMID: 2078406
- Korean J Nutr.
- 2007 Mar;40(2):111-117.
This study was designed to investigate the effects of pyroligneous liquor on oxygen radicals and their scavenger enzy-mes in the liver of Cri/Bgi CD rats (7 rats per group ).... -
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- The Inhibitory Effect of the Second Generation Sulfonylurea Drugs on Cytochrome P450-catalyzed Reaction by Human Liver Microsomes
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Choi JY, Kim SY, Kim KA, Park JY
- KMID: 2199993
- J Korean Soc Endocrinol.
- 2002 Aug;17(4):544-553.
BACKGROUND: Sulfonylurea drugs have been used for many decades as one of the main families of drugs for the treatment of type 2 diabetes mellitus. Even though there are many... -
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- Reduction in Binding of Aflatoxin B1 to Rat Liver DNA by Vitamin A and E Pretreatment
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Hong YS
- KMID: 1967556
- Ewha Med J.
- 1984 Jun;7(2):71-78.
- doi: 10.12771/emj.1984.7.2.71
We examined pattern of covalent modification of DNA produced in rat liver after exposure to single dose of aflatoxin B1. DNA-bound aflatoxin B1 adducts obtained from rat liver microsomes were... -
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- The Effects of Vitamin Antioxidants on Lipid Peroxidation in Carbon Tetrachloride, Phenobarbital and Artemisia Messes - Schmidiana Var Viridis - Preteated Rats Liver Microsomes
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Han EK, Hong YS, Sung HE, Pae YS
- KMID: 2009002
- Ewha Med J.
- 1983 Jun;6(2):57-64.
- doi: 10.12771/emj.1983.6.2.57
After rats were treated with CC14, phenobarbital and artemisia messes-schmiaiana var viridis(artemisia), hepatic microsomal cytochrome P-450, cytochrome b5 and lipid peroxidation were investigated. When vitamin A, C and E were... -
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- Induction of Hepatic Microsomal Cytochrome P450 by N,N-dimethylformamide in Sprague-Dawley Rats
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Koh SB, Cha BS, Kim KJ, Kang SK, Joung HS
- KMID: 2282984
- Korean J Prev Med.
- 1999 Feb;32(1):88-94.
OBJECTIVES: In order to gain a better understanding of the mechanism of DMF toxicity, recent studies have focused on hepatic drug metabolizing enzymes. In this study, we investigated the effects... -
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- Effect of Naloxone on the Mixed- Function Oxidation and Lipid Peroxidation in Rat Liver Microsomes
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Hong YS, Sung NE, Pae YS
- KMID: 1965692
- Ewha Med J.
- 1986 Sep;9(3):153-161.
- doi: 10.12771/emj.1986.9.3.153
The effects of Naloxone, narcotic antagonist, pretreated with normal saline, salicylate and hydrocortisone produced by with hypovolemic shock on the rates of cytochrome components, mixed function oxidation enzyme reactions and... -
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