Ewha Med J.  1982 Sep;5(3):109-116. 10.12771/emj.1982.5.3.109.

The Effects of Vitamin Antioxidants on Lipid Peroxidation in Rat Liver Microsomes

• Ham YA
• Hong YS
• Sung NE

• KMID: 1969220
• DOI: http://doi.org/10.12771/emj.1982.5.3.109

Abstract

We observed the effect of the administration of vitamin A,C and E with beta-naphthoflavone and piperonyl butoxide on cytochrome P-450 level and lipid peroxidation in rats liver. The level of hepatic cytochrome P-450 decreased after vitamin A,C and E was administration. In contrast, beta-naphthoflavone, when administered with vitamin A,C and E, the increase of cytochrome P-450 was prevented. Lipid peroxidation was decreased after vitamin A, C, and E was administered. Moreover when beta-naphthoflavone was administered together with vitamin A, C and E lipid peroxidation was not increased. When piperonyl butoxide was administered together with vitamin A,C and E, both cytochrome P-450 and lipid peroxidation were decreased. These results indicate that vitamin antioxidants can prevent lipid peroxidation by a cytochrome P-450 dependent terminal oxidase system in rat liver microsomes.

MeSH Terms

Animals
Antioxidants*
beta-Naphthoflavone
Cytochrome P-450 Enzyme System
Lipid Peroxidation*
Liver*
Microsomes, Liver*
Oxidoreductases
Piperonyl Butoxide
Rats*
Vitamin A
Vitamins*
Antioxidants
Cytochrome P-450 Enzyme System
Oxidoreductases
Piperonyl Butoxide
Vitamin A
Vitamins
beta-Naphthoflavone