Ewha Med J.  1983 Jun;6(2):57-64. 10.12771/emj.1983.6.2.57.

The Effects of Vitamin Antioxidants on Lipid Peroxidation in Carbon Tetrachloride, Phenobarbital and Artemisia Messes - Schmidiana Var Viridis - Preteated Rats Liver Microsomes

• Han EK
• Hong YS
• Sung HE
• Pae YS

• KMID: 2009002
• DOI: http://doi.org/10.12771/emj.1983.6.2.57

Abstract

After rats were treated with CC14, phenobarbital and artemisia messes-schmiaiana var viridis(artemisia), hepatic microsomal cytochrome P-450, cytochrome b5 and lipid peroxidation were investigated. When vitamin A, C and E were added incubation medium in each group respectively, lipid peroxidation was observed. The results were as follows. 1) When administrated with CC14 in rats, the contents of total microsomal cytochrome P-450 and cytochrome b5 were decreased by 58% and 36%, respectively. And lipid peroxidation was decreased to by 6%. 2) When administrated with phenobarbital and artemisia. in rats respectively, the contents of total microsomal cytochrome P-450 and cytochrome b5 were increased by 25 to 135%. And lipid peroxidation was increased by 30 to 57%. 3) When administrated with CC14 and phenobarbital or artemisia. in rats, the contents of total microsomal cytochrome P-450 and cytochrome b5 were increased by 8 to 35%. And lipid peroxidation was increased by 4 to 14%. 4) When vitamin A, C and E incubated in each group in each group in vitro, lipid peroxidation were decreased by 3 to 87%. And th higher concentrations of vitamin A, C and E were, the more lipid peroxidation was decreased. These results indicate that vitamin antioxidants can prevent lipid peroxidation in CC14, phenobarbital, CC14 with phenobarital. artemisia. and CC14 with artemisia.-pretreated rat liver microsomes.

MeSH Terms

Animals
Antioxidants*
Artemisia*
Carbon Tetrachloride*
Carbon*
Cytochrome P-450 Enzyme System
Cytochromes b5
Lipid Peroxidation*
Liver*
Microsomes, Liver*
Phenobarbital*
Rats*
Vitamin A
Vitamins*
Antioxidants
Carbon
Carbon Tetrachloride
Cytochrome P-450 Enzyme System
Cytochromes b5
Phenobarbital
Vitamin A
Vitamins