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Increased Serum Activity of Matrix Metalloproteinase-9 in Patients with Acute Variceal Bleeding

Kwon OS, Jung HS, Bae KS, Jung YK, Kim YS, Choi DJ, Kim YS, Kim JH

  • KMID: 2284272
  • Gut Liver.
  • 2012 Apr;6(2):249-255.
BACKGROUND/AIMS: Matrix metalloproteinases (MMP)-2 and -9 can degrade essential components of vascular integrity. The aim of this study was to investigate the association between those MMPs and variceal bleeding (VB). METHODS:...
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Regulation of Matrix Metalloproteinase 2 Expression by an Adenosine A1 Agonist in Trabecular Meshwork Cells

Baek MJ, Kim KH, Kim JW

PURPOSE: We investigated the extent of adenosine A1 agonist-induced expression and regulation of matrix metalloproteinase 2 (MMP-2) synthesis in human trabecular meshwork cells (HTMC). METHODS: Primary HTMC cultures were exposed to...
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Expression of MMP-2, MT1-MMP, and TIMP-2 mRNA in Breast Carcinomas

Kim DW, Jin SY, Lee DW

  • KMID: 1979368
  • Korean J Pathol.
  • 2003 Dec;37(6):400-406.
BACKGROUND: The activation of proMMP-2 is induced by membrane type 1-matrix metalloproteinase (MT1-MMP), but inhibited by tissue inhibitors of matrix metalloproteinase type 2 (TIMP-2). This study was carried out to...
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Expression of matrix metalloproteinase-2 and survivin in endometrioid and nonendometrioid endometrial cancers and clinicopathologic significance

Yilmaz E, Koyuncuoglu M, Gorken IB, Okyay E, Saatli B, Ulukus EC, Saygili U

OBJECTIVE: To determine matrix metalloproteinase-2 and survivin expressions in endometrial cancers, their relation to clinical and histologic parameters and to investigate any difference in the expression of these markers between...
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Altered Expression of Tissue Inhibitor of Matrix Metalloproteinase-2 in Complicated Mice Heart Secondary to Experimentally Induced Viral Myocarditis

Kim SS, Eom DW, Woo YJ, Suh JH, Huh J, Hong YM, Choi I

  • KMID: 2275603
  • Korean J Pathol.
  • 2001 Jun;35(3):196-200.
BACKGROUND: The pathogenesis of transition from viral myocarditis to dilated cardiomyopathy is elusive, although the incidence of dilated cardiomyopathy in human is increasing. METHODS: To clarify the role of the...
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Expression of Matrix Metalloproteinase-2 and -13 and Tissue Inhibitor of Metalloproteinase-4 in Varicose Veins

Chang JW, Maeng YH, Kim SW

BACKGROUND: The relationship between the degree of expression of matrix metalloproteinases or tissue inhibitor of metalloproteinases and venous reflux remains to be investigated. MATERIALS AND METHODS: Primary varicose vein tissues were...
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Effects of Hepatocyte Growth Factor on Collagen Synthesis and Matrix Metalloproteinase Production in Keloids

Lee WJ, Park SE, Rah DK

Keloids are pathologic proliferations of the dermal layer of the skin resulting from excessive collagen production and deposition. Hepatocyte growth factor (HGF) increases the expression of matrix metalloproteinase (MMP)-1 and...
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Expression of Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) in Pancreatic Ductal Adenocarcinoma

Gu MJ, Bae YK, Choi JH

  • KMID: 2275507
  • Korean J Pathol.
  • 2004 Apr;38(2):73-78.
BACKGROUND: Matrix metalloproteinase-2 (MMP-2) is known to be one of the key molecules for tumor invasion and metastasis. MMP-2 activity is modulated through interaction with the tissue inhibitor of metalloproteinase-2...
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Immunolocalization of Matrix Metalloproteinase-2, -9 and Tissue Inhibitor of Metalloproteinase-1, -2 in Suture-induced Corneal Neovascularization

Heo JG, Kim WS, Hwang DG

  • KMID: 2337021
  • J Korean Ophthalmol Soc.
  • 2002 Jun;43(6):1051-1061.
PURPOSE: Metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) have been linked to the angiogenic process in general. In order to understand the potential roles of MMPs and TIMPs in...
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The Clinical Significance of the Expression of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Renal Cell Carcinoma

Kim JY, Park TC, Baek SH

PURPOSE: Matrix metalloproteinases (MMPs) are endogenous peptidases that are capable of degrading various components of the basement membranes. To evaluate the clinical significance of the expressions of MMPs in renal...
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The Plasma Level of Matrix Metalloproteinase (MMP)-2, -9 between Antepartum and Postpartum Period in Preeclampsia

Chang HJ, Yang JI, Kim HB, Kim HS, Ryu HS, Oh KS

  • KMID: 2077113
  • Korean J Obstet Gynecol.
  • 2004 Aug;47(8):1487-1491.
OBJECTIVE: To evaluate the changes of plasma MMP-2, -9 levels in preeclampsia between antepartum and postpartum periods, and compare with normotensive pregnant. METHODS: Plasma MMP-2, -9 levels were determined with enzyme-linked...
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The Matrix metalloproteinase-2 & -9, Tissue inhibitor of metalloproteinase-1 & -2 mRNA Expression in Invasive Cervical Cancer

Moon HS, Choi EA, Yoo MY, Chung HW

  • KMID: 2076200
  • Korean J Obstet Gynecol.
  • 2001 Mar;44(3):532-539.
OBJECTIVE: Invasive cancer cells penetrate the extracellular matrix(ECM), including basement membrane during the metastatic cascades. Matrix metalloproteinases(MMPs) play a critical role in tumor invasion and metastasis and their activities are...
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Influence of Transforming Growth Factor-alpha on Expression of Matrix metalloproteinase-2 and Matrix metalloproteinase-9 mRNA in Mouse Embryos

Kim CH, Kim SH, Park EJ, Hong SH, Chae HD, Kang BM

  • KMID: 2262666
  • Korean J Obstet Gynecol.
  • 2002 Mar;45(3):443-449.
OBJECTIVE: To investigate the influence of transforming growth factor-alpha (TGF-alpha) on the expression of Matrix metalloproteinase-2 (MMP-2) and Matrix metalloproteinase-9 (MMP-9) mRNA in mouse embryos. MATERIALS AND METHOD: Eight-cell stage mouse...
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Effect of Oxidative Stress on the Expression of Gelatinases in Cultured RPE

Park YC, Choi GJ

  • KMID: 2337230
  • J Korean Ophthalmol Soc.
  • 2005 Nov;46(11):1903-1910.
PURPOSE: To evaluate the expression pattern of gelatinases in the human retinal pigment epithelial cell line ARPE-19 in response to oxidative stress. METHODS: ARPE-19 cells were exposed to paraquat for...
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Matrix Metalloproteinase-2, -9 Immunohistochemical staining in Cervical carcinoma: The Relationship with Clinicopathologic Prognostic Factors

Chung JY, Kim YM, Kim YT, Nam JH, Gong GY

  • KMID: 2076348
  • Korean J Obstet Gynecol.
  • 2001 Sep;44(9):1671-1677.
OBJECTIVE: Matrix metalloproteinase (MMP) has been reported to have a key role in the sequence of events that lead to local tumor invasion and metastasis. The present study was conducted...
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Influence of Transforming Growth Factor-alpha on Expression of Matrix Metalloproteinase-2, 9 and Epidermal Growth Factor Receptor Gene in the Mouse Blastocysts

Kim JH, Hong SH, Nah HY, Lee JY, Chae HD, Kim CH, Kang BM, Bae IH

  • KMID: 1979127
  • Korean J Fertil Steril.
  • 2001 Sep;28(3):173-182.
No abstract available.
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Role of Matrix Metalloproteinase (MMP) 2 and MMP-9 in Soft Tissue Sarcoma

Yang HK, Jeong KC, Kim YK, Jung ST

BACKGROUND: We investigated the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in malignant fibrous histiocytoma (MFH), and determined whether these could be useful as prognostic factors. METHODS:...
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Correlation of Serum Vascular Endothelial Growth Factor and Matrix Metalloproteinase-2 in Patients Complicated with Preeclampsia and Normotensive Pregnant Women

Lee KJ, Oh MJ, Kim HJ, Kim SH, Lee JK, Hur JY, Saw HS, Park YK

  • KMID: 2272497
  • Korean J Obstet Gynecol.
  • 2005 Jan;48(1):29-35.
OBJECTIVE: The aim of this study is to evaluate whether serum levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) are different between normotensive pregnant women and preeclampsia...
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The Effect of Platelet-rich Plasma on Wounds of OLETF Rats Using Expression of Matrix Metalloproteinase-2 and -9 mRNA

Shin HS, Oh HY

BACKGROUND: Complicated diabetic patients show impaired, delayed wound healing caused by multiple factors. A study on wound healing showed that platelet-rich plasma (PRP) was effective in normal tissue regeneration. Nonetheless,...
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Influence of Hepatocyte Growth Factor on Matrix Metalloproteinase Expression in HT cell line

Shin JC, Moon HB, Lee JH, Yang DE, Lee G, Lee Y, Lee JS, Kim CY, Kim SP

  • KMID: 2262480
  • Korean J Obstet Gynecol.
  • 2001 Dec;44(12):2257-2262.
OBJECTIVE: This study was performed to investigate the influence of hepatocyte growth factor (HGF) on matrix metalloproteinase (MMP), which are related in the lysis process of tissue during the invasion...
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