Korean J Thorac Cardiovasc Surg.  2011 Dec;44(6):387-391. 10.5090/kjtcs.2011.44.6.387.

Expression of Matrix Metalloproteinase-2 and -13 and Tissue Inhibitor of Metalloproteinase-4 in Varicose Veins

• Chang JW
• Maeng YH
• Kim SW

• KMID: 1447769
• DOI: http://doi.org/10.5090/kjtcs.2011.44.6.387

Abstract

BACKGROUND
The relationship between the degree of expression of matrix metalloproteinases or tissue inhibitor of metalloproteinases and venous reflux remains to be investigated.
MATERIALS AND METHODS
Primary varicose vein tissues were obtained from 23 patients, 18 females and 5 males, aged from 19 to 73. Cephalic or basilic veins were obtained for the control group from 10 patients who underwent vascular access for maintenance hemodialysis. Two operative techniques (high ligation with stripping or endovenous laser coagulation) were used. The expression of matrix metalloproteinase-2 and 13 and tissue inhibitor of metalloproteinase-4 in the varicose vein group and control group was assessed semi-quantitatively by immunohistochemical slides stained with primary antibodies.
RESULTS
Twenty (87%) of the varicose vein group patients had greater or lesser saphenous vein diseases with reflux. The focal weak (+) stain for matrix metalloproteinases-2, and 13, and tissue inhibitor of matrix metalloproteinase-4 was dominant in the varicose vein group; the focal or diffuse strong stain (++ or +++) was prevalent in the control group. The differences were statistically significant (p<0.01). The degree of reflux and the duration of symptoms were not significantly related to the expression of MMP-13 (p=0.317 and p=0.654, respectively).
CONCLUSION
Further study should be performed to investigate the relationship between the clinical characteristics related to venous hypertension or reflux and expression of MMPs and TIMP in varicose veins.

Keyword

Veins; Varicose veins; Extracellular matrix

MeSH Terms

Aged
Extracellular Matrix
Female
Humans
Hypertension
Ligation
Male
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Ocimum basilicum
Renal Dialysis
Saphenous Vein
Tissue Inhibitor of Metalloproteinases
Varicose Veins
Veins
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Tissue Inhibitor of Metalloproteinases