- Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-α
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Oh C, Kim HJ, Kim HM
- KMID: 2461018
- J Periodontal Implant Sci.
- 2019 Oct;49(5):270-286.
- doi: 10.5051/jpis.2019.49.5.270
PURPOSE: Despite the well-known anti-inflammatory effects of vitamin D in periodontal health, its mechanism has not been fully elucidated. In the present study, the effect of vitamin D on strengthening... -
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- Effect and Mechanism of Phosphodiesterase Inhibitors on Trabecular Outflow
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Kim JW, Lee JB, Lee SH
- KMID: 2459522
- Korean J Ophthalmol.
- 2019 Oct;33(5):414-421.
- doi: 10.3341/kjo.2019.0057
PURPOSE: Phosphodiesterase (PDE) inhibitors increase matrix metalloproteinase (MMP) production by inhibiting re-uptake of adenosine and may potentiate nitric oxide (NO) activity. This study was performed to investigate the effects and... -
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- Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation
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Park HS, Lee S, Lee J, Shin HB, Yoo SM, Lee MS, Park J
- KMID: 2455968
- Investig Clin Urol.
- 2019 Sep;60(5):396-404.
- doi: 10.4111/icu.2019.60.5.396
PURPOSE: CD81 is a prognostic biomarker for high-grade bladder cancer (BC). In this study, we aimed to determine the functional mechanisms underlying the role of CD81 in BC progression. MATERIALS AND... -
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- Comparison of Corticosteroids by 3 Approaches to the Treatment of Chronic Rhinosinusitis With Nasal Polyps
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Zhang Y, Lou H, Wang Y, Li Y, Zhang L, Wang C
- KMID: 2448751
- Allergy Asthma Immunol Res.
- 2019 Jul;11(4):482-497.
- doi: 10.4168/aair.2019.11.4.482
PURPOSE: Corticosteroids are regarded as the mainstay of medical treatment of eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To date, a head-to-head comparison of the efficacy and safety of glucocorticoid... -
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- German Cockroach Extract Induces Matrix Metalloproteinase-1 Expression, Leading to Tight Junction Disruption in Human Airway Epithelial Cells
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Lee KE, Jee HM, Hong JY, Kim MN, Oh MS, Kim YS, Kim KW, Kim KE, Sohn MH
- KMID: 2426337
- Yonsei Med J.
- 2018 Dec;59(10):1222-1231.
- doi: 10.3349/ymj.2018.59.10.1222
PURPOSE: Cockroach exposure is a pivotal cause of asthma. Tight junctions are intercellular structures required for maintenance of the barrier function of the airway epithelium, which is impaired in this... -
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- Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway
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Kang DG, Lee HJ, Lee CJ, Park JS
- KMID: 2427509
- Biomol Ther.
- 2018 Nov;26(6):560-567.
- doi: 10.4062/biomolther.2018.132
In the present study, we tried to examine whether resveratrol regulates the expression of matrix metalloproteinases (MMPs) through affecting nuclear factor-kappa B (NF-κB) in articular chondrocytes. Rabbit articular chondrocytes were... -
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- Platycodin D May Improve Acne and Prevent Scarring by Downregulating SREBP-1 Expression Via Inhibition of IGF-1R/PI3K/Akt Pathway and Modulating Inflammation with an Increase in Collagen
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Suh Y, Yang JH, Yoon JY, Choi YS
- KMID: 2419749
- Ann Dermatol.
- 2018 Oct;30(5):581-587.
- doi: 10.5021/ad.2018.30.5.581
BACKGROUND: Although many therapeutic agents have been developed, only a few drugs are known to target multiple pathogenic factors in the treatment of acne. OBJECTIVE: The purpose of this study was... -
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- Compound K Inhibits Interleukin-1β-induced Expression of Inflammatory Mediators and Matrix Metalloproteinases by Inhibiting Mitogen-activated Protein Kinase Activation in Chondrocytes
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Park EH, Kim JS, Lee JS, Lee YJ, Song YW, Lee EY
- KMID: 2415607
- J Rheum Dis.
- 2018 Jul;25(3):188-196.
- doi: 10.4078/jrd.2018.25.3.188
OBJECTIVE: This study examined the anti-inflammatory and chondroprotective effects of compound K (CK), a ginsenoside metabolite, on chondrocytes from osteoarthritis (OA) patients following stimulation with interleukin (IL)-1β. METHODS: Articular cartilage samples... -
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- Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients
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Gho WG, Choi Y, Park KH, Huh JK
- KMID: 2414431
- J Korean Assoc Oral Maxillofac Surg.
- 2018 Jun;44(3):120-127.
- doi: 10.5125/jkaoms.2018.44.3.120
OBJECTIVES: The aim of this study was to reveal how collagenases (matrix metalloproteinase [MMP]-1, 8, 13) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are expressed in immunohistochemistry of retrodiscal tissue... -
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- Troglitazone Inhibits Matrix Metalloproteinase-9 Expression and Invasion of Breast Cancer Cell through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism
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Hong OY, Youn HJ, Jang HY, Jung SH, Noh EM, Chae HS, Jeong YJ, Kim W, Kim CH, Kim JS
- KMID: 2441865
- J Breast Cancer.
- 2018 Mar;21(1):28-36.
- doi: 10.4048/jbc.2018.21.1.28
PURPOSE: Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. Matrix metalloproteinases (MMPs) play a significant role in tissue remodeling... -
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- Serum matrix metalloproteinase-1 level represents disease activity as opposed to fibrosis in patients with histologically proven nonalcoholic steatohepatitis
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Ando W, Yokomori H, Tsutsui N, Yamanouchi E, Suzuki Y, Oda M, Inagaki Y, Otori K, Okazaki I
- KMID: 2429084
- Clin Mol Hepatol.
- 2018 Mar;24(1):61-76.
- doi: 10.3350/cmh.2017.0030
BACKGROUND/AIMS: Nonalcoholic steatohepatitis (NASH) is prevalent in both economically developed and developing countries. Twenty percent of NASH progresses to cirrhosis with/without hepatocellular carcinoma, and there is an urgent need to... -
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- Effects of salmon DNA fraction in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model
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Ra HJ, Oh MY, Kim HJ, Lee SY, Eom DW, Lee SK, Kim SN, Chung KS, Jang HJ
- KMID: 2410106
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):163-172.
- doi: 10.4196/kjpp.2018.22.2.163
PRF001 is a fragmented DNA polymer extracted from the testes of salmon. The purpose of this study was to assess the anti-inflammatory effect of PRF001 in vitro as well as... -
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- Relaxin Modulates the Expression of MMPs and TIMPs in Fibroblasts of Patients with Carpal Tunnel Syndrome
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Kang YM, Lee HM, Moon SH, Kang H, Choi YR
- KMID: 2427132
- Yonsei Med J.
- 2017 Mar;58(2):415-422.
- doi: 10.3349/ymj.2017.58.2.415
PURPOSE: The aim of this study was to investigate the anti-fibrotic effect of relaxin in subsynovial fibroblasts activated by transforming growth factor beta (TGF-β). MATERIALS AND METHODS: To test the anti-fibrotic... -
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- Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K/Akt Signaling Pathway
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Choi EO, Cho EJ, Jeong JW, Park C, Hong SH, Hwang HJ, Moon SK, Son CG, Kim WJ, Choi YH
- KMID: 2375042
- Biomol Ther.
- 2017 Mar;25(2):213-221.
- doi: 10.4062/biomolther.2016.094
Baicalein, a natural flavonoid obtained from the rhizome of Scutellaria baicalensis Georgi, has been reported to have anticancer activities in several human cancer cell lines. However, its antimetastatic effects and... -
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- Effect of oleanolic acid on the activity, secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo
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Kang DG, Lee HJ, Kim KT, Hwang SC, Lee CJ, Park JS
- KMID: 2371038
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):197-204.
- doi: 10.4196/kjpp.2017.21.2.197
In the present study, we tried to examine whether oleanolic acid regulates the activity, secretion and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well... -
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- Effects of gangliosides from deer bone extract on the gene expressions of matrix metalloproteinases and collagen type II in interleukin-1β-induced osteoarthritic chondrocytes
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Suh HJ, Lee H, Min BJ, Jung SU, Jung EY
- KMID: 2359612
- Nutr Res Pract.
- 2016 Dec;10(6):569-574.
- doi: 10.4162/nrp.2016.10.6.569
BACKGROUND/OBJECTIVES: We investigated the anti-osteoarthritic effects of deer bone extract on the gene expressions of matrix metalloproteinases (MMPs) and collagen type II (COL2) in interleukin-1β-induced osteoarthritis (OA) chondrocytes. MATERIALS/METHODS: Primary rabbit... -
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- Metallothinein 1E Enhances Glioma Invasion through Modulation Matrix Metalloproteinases-2 and 9 in U87MG Mouse Brain Tumor Model
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Hur H, Ryu HH, Li CH, Kim IY, Jang WY, Jung S
- KMID: 2417335
- J Korean Neurosurg Soc.
- 2016 Nov;59(6):551-558.
- doi: 10.3340/jkns.2016.59.6.551
Malignant glioma cells invading surrounding normal brain are inoperable and resistant to radio- and chemotherapy, and eventually lead to tumor regrowth. Identification of genes related to motility is important for... -
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- Pamidronate Down-regulates Tumor Necrosis Factor-alpha Induced Matrix Metalloproteinases Expression in Human Intervertebral Disc Cells
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Kang YM, Hong SH, Yang JH, Oh JC, Park JO, Lee BH, Lee SY, Kim HS, Lee HM, Moon SH
- KMID: 2350813
- J Bone Metab.
- 2016 Aug;23(3):165-173.
- doi: 10.11005/jbm.2016.23.3.165
BACKGROUND: N-containing bisphosphonates (BPs), such as pamidronate and risedronate, can inhibit osteoclastic function and reduce osteoclast number by inducing apoptotic cell death in osteoclasts. The aim of this study is... -
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- SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes
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Ha YJ, Choi YS, Kang EH, Shin K, Kim TK, Song YW, Lee YJ
- KMID: 2361528
- Exp Mol Med.
- 2016 Jun;48(6):e241.
- doi: 10.1038/emm.2016.47
CAAT/enhancer-binding protein-beta (C/EBPβ) is a transcription factor that regulates interleukin-1β (IL-1β)-induced catabolic pathways, including the expression of matrix metalloproteinases (MMPs), in chondrocytes. We previously reported that suppressor of cytokine signaling... -
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- The Inhibitory Effects of Forsythia Koreana Extracts on the Metastatic Ability of Breast Cancer Cells and Bone Resorption by Osteoclasts
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Kim YL, Lee SK, Park KK, Chung WY
- KMID: 2353808
- J Cancer Prev.
- 2016 Jun;21(2):88-94.
- doi: 10.15430/JCP.2016.21.2.88
BACKGROUND: Breast cancer is the most common malignant disease in women. The patients with advanced breast cancer develop metastasis to bone. Bone metastasis and skeletal-related events by breast cancer are... -
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