Restor Dent Endod.  2012 Mar;37(1):2-8. 10.5395/rde.2012.37.1.2.

Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion

Affiliations
  • 1Department of Conservative Dentistry, Seoul National University School of Dentistry, Seoul, Korea. hhson@snu.ac.kr
  • 2Clinic for Persons with Disabilities, Seoul National University Dental Hospital, Seoul, Korea.

Abstract

The limited durability of resin-dentin bonds severely compromises the longevity of composite resin restorations. Resin-dentin bond degradation might occur via degradation of water-rich and resin sparse collagen matrices by host-derived matrix metalloproteinases (MMPs). This review article provides overview of current knowledge of the role of MMPs in dentin matrix degradation and four experimental strategies for extending the longevity of resin-dentin bonds. They include: (1) the use of broad-spectrum inhibitors of MMPs, (2) the use of cross-linking agents for silencing the activities of MMPs, (3) ethanol wet-bonding with hydrophobic resin, (4) biomimetic remineralization of water-filled collagen matrix. A combination of these strategies will be able to overcome the limitations in resin-dentin adhesion.

Keyword

Biomimetic remineralization; Chlorhexidine; Cross-linking agent; Dentin bonding; Ethanol wet-bonding; Matrix metalloproteinase

MeSH Terms

Biomimetics
Chlorhexidine
Collagen
Dentin
Ethanol
Longevity
Matrix Metalloproteinases
Chlorhexidine
Collagen
Ethanol
Matrix Metalloproteinases

Reference

1. Hashimoto M, Ohno H, Kaga M, Endo K, Sano H, Oguchi H. In vivo degradation of resin-dentin bonds in humans over 1 to 3 years. J Dent Res. 2000. 79:1385–1391.
Article
2. Sano H, Yoshikawa T, Pereira PN, Kanemura N, Morigami M, Tagami J, Pashley DH. Long-term durability of dentin bonds made with a self-etching primer, in vivo. J Dent Res. 1999. 78:906–911.
Article
3. Takahashi A, Inoue S, Kawamoto C, Ominato R, Tanaka T, Sato Y, Pereira PN, Sano H. In vivo long-term durability of the bond to dentin using two adhesive systems. J Adhes Dent. 2002. 4:151–159.
4. De Munck J, van Meerbeek B, Yoshida Y, Inoue S, Vargas M, Suzuki K, Lambrechts P, Vanherle G. Four-year water degradation of total-etch adhesives bonded to dentin. J Dent Res. 2003. 82:136–140.
Article
5. Hashimoto M, Ohno H, Sano H, Kaga M, Oguchi H. Degradation patterns of different adhesives and bonding procedures. J Biomed Mater Res B Appl Biomater. 2003. 66:324–330.
Article
6. Wang Y, Spencer P. Quantifying adhesive penetration in adhesive/dentin interface using confocal Raman microspectroscopy. J Biomed Mater Res. 2002. 59:46–55.
Article
7. Sano H, Takatsu T, Ciucchi B, Horner JA, Matthews WG, Pashley DH. Nanoleakage: leakage within the hybrid layer. Oper Dent. 1995. 20:18–25.
8. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 2003. 92:827–839.
9. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med. 1993. 4:197–250.
Article
10. Mazzoni A, Pashley DH, Tay FR, Gobbi P, Orsini G, Ruggeri A Jr, Carrilho M, Tjäderhane L, Di Lenarda R, Breschi L. Immunohistochemical identification of MMP-2 and MMP-9 in human dentin: correlative FEI-SEM/TEM analysis. J Biomed Mater Res A. 2009. 88:697–703.
Article
11. Martin-De Las Heras S, Valenzuela A, Overall CM. The matrix metalloproteinase gelatinase A in human dentine. Arch Oral Biol. 2000. 45:757–765.
Article
12. Tjäderhane L, Palosaari H, Wahlgren J, Larmas M, Sorsa T, Salo T. Human odontoblast culture method: the expression of collagen and matrix metalloproteinases (MMPs). Adv Dent Res. 2001. 15:55–58.
Article
13. Tjäderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T. The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res. 1998. 77:1622–1629.
Article
14. Lee W, Aitken S, Sodek J, McCulloch CA. Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis. J Periodontal Res. 1995. 30:23–33.
Article
15. Pashley DH, Tay FR, Yiu C, Hashimoto M, Breschi L, Carvalho RM, Ito S. Collagen degradation by host-derived enzymes during aging. J Dent Res. 2004. 83:216–221.
Article
16. Nishitani Y, Yoshiyama M, Wadgaonkar B, Breschi L, Mannello F, Mazzoni A, Carvalho RM, Tjäderhane L, Tay FR, Pashley DH. Activation of gelatinolytic/collagenolytic activity in dentin by self-etching adhesives. Eur J Oral Sci. 2006. 114:160–166.
Article
17. Mazzoni A, Pashley DH, Nishitani Y, Breschi L, Mannello F, Tjäderhane L, Toledano M, Pashley EL, Tay FR. Reactivation of inactivated endogenous proteolytic activities in phosphoric acid-etched dentine by etch-and-rinse adhesives. Biomaterials. 2006. 27:4470–4476.
Article
18. Hebling J, Pashley DH, Tjäderhane L, Tay FR. Chlorhexidine arrests subclinical degradation of dentn hybrid layers in vivo. J Dent Res. 2005. 84:741–746.
Article
19. Wang Y, Spencer P. Quantifying adhesive penetration in adhesive/dentin interface using confocal Raman microspectroscopy. J Biomed Mater Res. 2002. 59:46–55.
Article
20. Carrilho MR, Carvalho RM, Tay FR, Yiu C, Pashely DH. Durability of resin-dentin bonds related to water and oil storage. Am J Dent. 2005. 18:315–319.
21. Mohammadi Z, Abbott PV. Antimicrobial substantivity of root canal irrigants and medicaments: a review. Aust Endod J. 2009. 35:131–139.
Article
22. Kim J, Uchiyama T, Carrilho M, Agee KA, Mazzoni A, Breschi L, Carvalho RM, Tjäderhane L, Looney S, Wimmer C, Tezvergil-Mutluay A, Tay FR, Pashley DH. Chlorhexidine binding to mineralized versus demineralized dentin powder. Dent Mater. 2010. 26:771–778.
Article
23. Carrilho MR, Geraldeli S, Tay F, de Goes MF, Carvalho RM, Tjäderhane L, Reis AF, Hebling J, Mazzoni A, Breschi L, Pashley D. In vivo preservation of the hybrid layer by chlorhexidine. J Dent Res. 2007. 86:529–533.
Article
24. Sadek FT, Braga RR, Muench A, Liu Y, Pashley DH, Tay FR. Ethanol wet-bonding challenges current antidegradation strategy. J Dent Res. 2010. 89:1499–1504.
Article
25. Zhou J, Tan J, Yang X, Cheng C, Wang X, Chen L. Effect of chlorhexidine application in a self-etching adhesive on the immediate resin-dentin bond strength. J Adhes Dent. 2010. 12:27–31.
26. Cadenaro M, Pashley DH, Marchesi G, Carrilho M, Antoniolli F, Mazzoni A, Tay FR, Di Lenarda R, Breschi L. Influence of chlorhexidine on the degree of conversion and E-modulus of experimental adhesive blends. Dent Mater. 2009. 25:1269–1274.
Article
27. Hiraishi N, Yiu CK, King NM, Tay FR, Pashley DH. Chlorhexidine release and water sorption characteristics of chlorhexidine-incororated hydrophobic/hydrophilic resins. Dent Mater. 2008. 24:1391–1399.
Article
28. Breschi L, Martin P, Mazzoni A, Nato F, Carrilho M, Tjäderhane L, Visintini E, Cadenaro M, Tay FR, De Stefano Dorigo E, Pashley DH. Use of a specific MMP-inhibitor (galardin) for preservation of hybrid layer. Dent Mater. 2010. 26:571–578.
Article
29. Al-Ammar A, Drummond JL, Bedran-Russo AK. The use of collagen cross-linking agents to enhance dentin bond strength. J Biomed Mater Res B Appl Biomater. 2009. 91:419–424.
Article
30. Matchett MD, MacKinnon SL, Sweeney MI, Gottschall-Pass KT, Hurta RA. Blueberry flavonoids inhbit matrix metalloproteinase activity in DU145 human prostate cancer cells. Biochem Cell Biol. 2005. 83:637–643.
Article
31. Busenlehner LS, Armstrong RN. Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry. Arch Biochem Biophys. 2005. 433:34–46.
Article
32. Sela-Passwell N, Rosenblum G, Shoham T, Sagi I. Structural and functional bases for allosteric control of MMP activities: can it pave the path for selective inhibition? Biochim Biophys Acta. 2010. 1803:29–38.
Article
33. O'Farrell TJ, Guo R, Hasegawa H, Pourmotabbed T. Matrix metalloproteinase-1 takes advantage of the induced fit mechanism to cleave the triple-helical type I collagen molecule. Biochemistry. 2006. 45:15411–15418.
34. Lauer-Fields JL, Chalmers MJ, Busby SA, Minond D, Griffin PR, Fields GB. Identification of specific hemopexin-like domain residues that facilirate matrix metalloproreinase collagenolytic activity. J Biol Chem. 2009. 284:24017–24024.
Article
35. Calero P, Jorge-Herrero E, Turray J, Olmo N, López de Silanes I, Lizarbe MA, Maestro MM, Arenaz B, Castillo-Olivares JL. Gelatinases in soft tissue biomaterials. Analysis of different crosslinking agents. Biomaterials. 2002. 23:3473–3478.
Article
36. Carrilho MR, Tay FR, Donnelly AM, Agee KA, Tjäderhane L, Mazzoni A, Breschi L, Foulger S, Pashley DH. Host-derived loss of dentin matrix stiffness associated with solubilization of collagen. J Biomed Mater Res B Appl Biomater. 2009. 90:373–380.
Article
37. Chiaraputt S, Mai S, Huffman BP, Kapur R, Agee KA, Yiu CK, Chan DC, Harnirattisai C, Arola DD, Rueggeberg FA, Pashley DH, Tay FR. Changes in resin-infiltrated dentin stiffness after water storage. J Dent Res. 2008. 87:655–660.
Article
38. Kinney JH, Habelitz S, Marshall SJ, Marshal GW. The importance of intrafibrillar mineralization of collagen on the mechanical properties of dentin. J Dent Res. 2003. 82:957–961.
Article
39. Tay FR, Pashley DH, Kapur RR, Carrilho MR, Hur YB, Garrett LV, Tay KC. Bonding BisGMA to dentin-a proof of concept for hydrophobic dentin bonding. J Dent Res. 2007. 86:1034–1039.
Article
40. Sauro S, Watson TF, Mannocci F, Mitake K, Huffman BP, Tay FR, Pashley DH. Two-photon laser confocal microscopy of micropermeability of resin-dentin bonds made with water or ethanol wet bondng. J Biomed Mater Res B Appl Biomater. 2009. 90:327–337.
41. Sauro S, Toledano M, Aguilera FS, Mannocci F, Pashley DH, Tay FR, Watson TF, Osorio R. Resin-dentin bonds to EDTA-treated vs. acid-etched dentin using ethanol wet-bonding. Dent Mater. 2010. 26:368–379.
Article
42. Sadek FT, Pashley DH, Ferrari M, Tay FR. Tubular occlusion optimizes bonding of hydrophobic resins to dentin. J Dent Res. 2007. 86:524–528.
Article
43. Osorio E, Toledano M, Aguilera FS, Tay FR, Osorio R. Ethanol wet bonding technique sensitivity assessed by AFM. J Dent Res. 2010. 89:1264–1269.
Article
44. Nishitani Y, Yoshiyama M, Donnelly AM, Agee KA, Sword J, Tay FR, Pashley DH. Effects of resin hydrophilicity on dentin bond strength. J Dent Res. 2006. 85:1016–1021.
Article
45. Malacarne J, Carvalho RM, de Goes MF, Svizero N, Pashley DH, Tay FR, Yiu CK, Carrilho MR. Water sorption/solubility of dental adhesive resins. Dent Mater. 2006. 22:973–980.
Article
46. Sadek FT, Braga RR, Muench A, Liu Y, Pashley DH, Tay FR. Ethanol wet-bonding challenges current anti-degradation strategy. J Dent Res. 2010. 89:1499–1504.
Article
47. Lees S, Page EA. A study of some properties of mineralized turkey leg tendon. Connect Tissue Res. 1992. 28:263–287.
Article
48. Toroian D, Lim JE, Price PA. The size exclusion characteristics of type I collagen: implications for the role of noncollagenous bone constituents in mineralization. J Biol Chem. 2007. 282:22437–22447.
49. Chesnick IE, Mason JT, Giuseppetti AA, Eidelman N, Potter K. Magnetic resonance microscopy of collagen mineralization. Biophys J. 2008. 95:2017–2026.
Article
50. Tay FR, Pashley DH. Biomimetic remineralization of resin-bonded acid-etched dentin. J Dent Res. 2009. 88:719–724.
Article
51. Gu LS, Huffman BP, Arola DD, Kim YK, Mai S, Elsalanty ME, Ling JQ, Pashley DH, Tay FR. Changes in stiffness of resin-infiltrated demineralized dentin after remineralization by a botton-up biomimetic approach. Acta Biomater. 2010. 6:1453–1461.
Article
52. George A, Veis A. Phosphorylated proteins and control over apatite nucleation, crystal growth, and inhibition. Chem Rev. 2008. 108:4670–4693.
Article
53. Wong TS, Brough B, Ho CM. Creation of functional micro/nano systems through top-down and bottom-up approaches. Mol Cell Biomech. 2009. 6:1–55.
54. Girija EK, Yokogawa Y, Nagata F. Apatite formation on collagen fibrils in the presence of polyacrylic acid. J Mater Sci Mater Med. 2004. 15:593–599.
Article
55. Gajjeraman S, He G, Narayanan K, George A. Biological assemblies provide novel templates for the synthesis of hierarchical structures and facilitate cell adhesion. Adv Funct Mater. 2008. 18:3972–3980.
Article
56. Mai S, Kim YK, Kim J, Yiu CK, Ling J, Pashley DH, Tay FR. In vitro remineralization of severely compromised bonded dentin. J Dent Res. 2010. 89:405–410.
Article
57. Kim J, Vaughn RM, Gu L, Rockman RA, Arola DD, Schafer TE, Choi KK, Pashley DH, Tay FR. Imperfect hybrid layers created by an aggressive one-step self-etch adhesive in primary dentin are amendable to biominetic remineralization in vitro. J Biomed Mater Res A. 2010. 93:1225–1234.
58. Tezvergil-Mutluay A, Agee KA, Hoshika T, Tay FR, Pashley DH. The inhibitory effect of polyvinylphosphonic acid on functional matrix metalloproteinase activities in human demineralized dentin. Acta Biomater. 2010. 6:4136–4142.
Article
59. Kim YK, Gu LS, Bryan TE, Kim JR, Chen L, Liu Y, Yoon JC, Breschi L, Pashley DH, Tay FR. Mineralisation of reconstituted collagen using polyvinylphophonic acid/polyacrylic acid templating matrix protein analogues in the presence of calcium, phosphate and hydroxyl ions. Biomaterials. 2010. 31:6618–6627.
Article
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