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Effect of FTY-720 on Pulmonary Fibrosis in Mice via the TGF-β1 Signaling Pathway and Autophagy

Jin Y, Liu W, Gao G, Song Y, Liu H, Li L, Zhou J, Yan G, Cui H

We investigated whether FTY-720 might have an effect on bleomycin-induced pulmonary fibrosis through inhibiting TGF-β1 pathway, and up-regulating autophagy. The pulmonary fibrosis was induced by bleomycin. FTY-720 (1 mg/kg) drug...
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Massive gastric dilatation

Wei DH, Peng YK, Liu W

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Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways

Zhao H, Liu W, Wang Y, Dai N, Gu J, Yuan Y, Liu X, Bian J, Liu ZP

Exposure to cadmium (Cd) induces apoptosis in osteoblasts (OBs); however, little information is available regarding the specific mechanisms of Cd-induced primary rat OB apoptosis. In this study, Cd reduced cell...
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Can CD44+/CD24- Tumor Cells Be Used to Determine the Extent of Breast Cancer Invasion Following Neoadjuvant Chemotherapy?

Wu H, Li R, Hang X, Yan M, Niu F, Liu L, Liu W, Zhao S, Zhang S

  • KMID: 2394769
  • J Breast Cancer.
  • 2011 Sep;14(3):175-180.
PURPOSE: To investigate the distribution of CD44+/CD24- cells in breast cancers in relation to tumor size before and after the administration of neoadjuvant chemotherapy. METHODS: CD44+/CD24- tumor cells obtained from breast...
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Black rice anthocyanidins prevent retinal photochemical damage via involvement of the AP-1/NF-kappaB/Caspase-1 pathway in Sprague-Dawley Rats

Jia H, Chen W, Yu X, Wu X, Li S, Liu H, Liao J, Liu W, Mi M, Liu L, Cheng D

The effects of black rice anthocyanidins (BRACs) on retinal damage induced by photochemical stress are not well known. In the present study, Sprague-Dawley rats were fed AIN-93M for 1 week,...
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Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats

Zhang Z, Chen T, Liu W, Xiong J, Jiang L, Liu M

Diabetic ulcer is usually seen in people with uncontrolled blood sugar. Reportedly, many factors such as impaired glucose metabolism, and macrovascular and microvascular diseases caused angiogenesis disorders and delayed the healing...
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Prevalence and Phylogenetic Analyses of Trichuris suis in Pigs in Hunan Province, Subtropical China

Tan L, Wang A, Yi J, Liu Y, Li J, Liu W

Trichuris suis infection in pigs is ubiquitous in intensive and extensive farms, which causes potential threat to human health. The objective of this research was to investigate the prevalence of...
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miR-98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL-6

Li F, Li XJ, Qiao L, Shi F, Liu W, Li Y, Dang YP, Gu WJ, Wang XG, Liu W

Dysregulated microRNA (miRNA) expression has a critical role in tumor development and metastasis. However, the mechanism by which miRNAs control melanoma metastasis is unknown. Here, we report reduced miR-98 expression...
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Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers

Lin H, Huang Q, Guo X, Liu P, Liu W, Zou Y, Zhu S, Deng G, Kuang J, Zhang C, Cao H, Hu G

To assess relationships between xanthine oxidase (XOD) and nephropathogenic infectious bronchitis virus (NIBV) infection, 240 growing layers (35 days old) were randomly divided into two groups (infected and control) of...
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Electrospun Fibrous Silk Fibroin/Poly(L-Lactic Acid) Scaffold for Cartilage Tissue Engineering

Liu W, Li Z, Zheng L, Zhang X, Liu P, Yang T, Han B

For successful tissue engineering of articular cartilage, a scaffold with mechanical properties that match those of natural cartilage as closely as possible is needed. In the present study, we prepared...
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The Combination of Platelet Rich Plasma Gel, Human Umbilical Mesenchymal Stem Cells and Nanohydroxyapatite/polyamide 66 Promotes Angiogenesis and Bone Regeneration in Large Bone Defect

Liu W, Huang Y, Liu D, Zeng T, Wang J, Li A, Wang D, Wang X

BACKGROUND: In the present study, a novel tissue engineering bone graft including platelet rich plasma gel (PRP gel), human umbilical mesenchymal stem cells (HUMSCs) and nanohydroxyapatite/polyamide 66 (nHA-PA66) was constructed....
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Erratum: The effect of various sandblasting conditions on surface changes of dental zirconia and shear bond strength between zirconia core and indirect composite resin

Su N, Yue L, Liao Y, Liu W, Zhang H, Li X, Wang H, Shen J

On page 219, there was an error in the Fig. 5.
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Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1a Signaling Pathway

Liu W, Yuan Y, Liu D

BACKGROUND: Impaired potential of hypoxia-mediated angiogenesis lead poor healing of diabetic wounds. Previous studies have shown that extracellular vesicles from adipose derived stem cells (ADSC-EVs) accelerate wound healing with unelucidated...
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Hair Growth Promoting Effects of 650 nm Red Light Stimulation on Human Hair Follicles and Study of Its Mechanisms via RNA Sequencing Transcriptome Analysis

Yang K, Tang Y, Ma Y, Liu Q, Huang Y, Zhang Y, Shi X, Zhang L, Zhang Y, Wang J, Zhu Y, Liu W, Tan Y, Lin J, Wu W

Background: Androgenetic alopecia (AGA) leads to thinning of scalp hair and affects 60%~70% of the adult population worldwide. Developing more effective treatments and studying its mechanism are of great significance....
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Identification and Validation of Circulating MicroRNA Signatures for Breast Cancer Early Detection Based on Large Scale Tissue-Derived Data

Yu X, Liang J, Xu J, Li X, Xing S, Li H, Liu W, Liu D, Xu J, Huang L, Du H

PURPOSE: Breast cancer is the most commonly occurring cancer among women worldwide, and therefore, improved approaches for its early detection are urgently needed. As microRNAs (miRNAs) are increasingly recognized as...
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Photoacoustic microscopy: principles and biomedical applications

Liu W, Yao J

Photoacoustic microscopy (PAM) has become an increasingly popular technology for biomedical applications, providing anatomical, functional, and molecular information. In this concise review, we first introduce the basic principles and typical...
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Gene therapy of scarring: a lesson learned from fetal scarless wound healing

Liu W, Cao Y, Longaker M

Cutaneous wounding in adult humans and higher vertebrate animals results in scar formation. In contrast, both human and animal fetuses, at early gestational ages, exhibit skin wound healing without scarring....
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A rapid and quantitative fluorescent microsphere immunochromatographic strip test for detection of antibodies to porcine reproductive and respiratory syndrome virus

Wei Y, Yang B, Li Y, Duan Y, Tian D, He B, Chen C, Liu W, Yang L

A fluorescent microsphere-based immunochromatographic strip test (FICT) was developed for the rapid, sensitive, and quantitative detection of porcine reproductive and respiratory syndrome virus (PRRSV) antibodies at the pen-side. The assay...
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METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury

Guo S, Lin T, Chen G, Shangguan Z, Zhou L, Chen Z, Shi T, Chen D, Wang Z, Liu W

Objective: Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA. The role of METTL3, the...
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p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line

Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J

  • KMID: 1115940
  • Exp Mol Med.
  • 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known...
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