- Role of zinc for calcification inhibitor protein in vascular smooth muscle cell plaque formation
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Shin MY, Kwun IS
- KMID: 2158307
- J Nutr Health.
- 2016 Feb;49(1):59-62.
- doi: 10.4163/jnh.2016.49.1.59
PURPOSE: Zinc, a biomineral present within and outside cells, manages various cellular mechanisms. In this study, we examined whether zinc was involved in vascular smooth muscle cell (VSMC) calcification via... -
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- Vitamin D: Hormone-like nutrient
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Shin MY, Kwun IS
- KMID: 2158300
- J Nutr Health.
- 2016 Feb;49(1):1-7.
- doi: 10.4163/jnh.2016.49.1.1
PURPOSE: The aim of this review is to comprehensively summarize the definition of vitamin D as a nutrient as well as a hormone-like molecule and its new function in prevention... -
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- 2020 Dietary Reference Intakes for Koreans: zinc
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Lee MK, Kim EM, Kwun IS
- KMID: 2532905
- J Nutr Health.
- 2022 Aug;55(4):441-449.
- doi: 10.4163/jnh.2022.55.4.441
This review is focused on analyzing the limits and shortage of zinc (Zn) for the 2020 Dietary Reference Intakes for Koreans (KDRIs), and provides suggestions for the future establishment of... -
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- Zinc modulation of osterix in MC3T3-E1 cells
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Seo HJ, Jeong JB, Cho YE, Kwun IS
- KMID: 2506197
- J Nutr Health.
- 2020 Aug;53(4):347-355.
- doi: 10.4163/jnh.2020.53.4.347
Purpose: Zinc is known to be associated with osteoblast proliferation and differentiation. Osterix as zinc-finger transcription factor is also related to osteoblast differentiation and bone formation. In the present study, we... -
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- Effects of Corn Peptide Consumption on Plasma Lipid Profiles in Cholesterol-Fed Rats
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Moon MS, Lee JH, Lee MS, Kwun IS, Chung YI, Lee DH, Kim Y
- KMID: 2270055
- Korean J Nutr.
- 2006 Dec;39(8):728-732.
In this study, the effects of corn peptide consumption on plasma lipid profiles were investigated in high cholesterol dietfed rats. Male Sprague-Dawley rats (n = 21) were fed with corn... -
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- Relation Dietary and Urinary Na, K, and Ca Level to Blood Pressure in Elderly People in Rural Area
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Kwak EH, Lee SL, Lee HS, Kwun IS
- KMID: 2235859
- Korean J Nutr.
- 2003 Jan;36(1):75-82.
It has been considered that high Na intake, and low Ca/K intake are related to the incidence of hypertension. In this preliminary study, dietary Na, K, and Ca intake and... -
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- Zinc upregulates bone-specific transcription factor Runx2 expression via BMP-2 signaling and Smad-1 phosphorylation in osteoblasts
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Cho YE, Kwun IS
- KMID: 2410322
- J Nutr Health.
- 2018 Feb;51(1):23-30.
- doi: 10.4163/jnh.2018.51.1.23
PURPOSE: Runx2 (runt-related transcription factor 2), a bone-specific transcription factor, is a key regulator of osteoblast differentiation and its expression is induced by the activation of BMP-2 signaling. This study... -
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- The decreased molar ratio of phytate:zinc improved zinc nutriture in South Koreans for the past 30 years (1969-1998)
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Do MS, Lomeda RA, Cho YE, Kwun IS
- KMID: 2313338
- Nutr Res Pract.
- 2007 Dec;1(4):356-362.
For the assessment of representative and longitudinal Zn nutriture in South Koreans, Zn, phytate and Ca intakes were determined using four consecutive years of food consumption data taken from Korean... -
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- Cellular zinc deficiency inhibits the mineralized nodule formation and downregulates bone-specific gene expression in osteoblastic MC3T3-E1 cells
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Cho YE, Kwun IS
- KMID: 2427761
- J Nutr Health.
- 2018 Oct;51(5):379-385.
- doi: 10.4163/jnh.2018.51.5.379
PURPOSE: Zinc (Zn) is an essential trace element for bone mineralization and osteoblast function. We examined the effects of Zn deficiency on osteoblast differentiation and mineralization in MC3T3-E1 cells. METHODS: Osteoblastic... -
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- The function of zinc in the primary vascular smooth muscle cell proliferation in rats
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Cho YE, Kwun IS
- KMID: 2510201
- J Nutr Health.
- 2020 Dec;53(6):563-569.
- doi: 10.4163/jnh.2020.53.6.563
Purpose: The vascular smooth muscle cells (VSMCs) in mature animals have implicated to play a major role in the progression of cardiovascular diseases such as atherosclerosis. This study aimed at... -
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- Glycyrrhiza uralensis (licorice) extracts increase cell proliferation and bone marker enzyme alkaline phosphatase activity in osteoblastic MC3T3-E1 cells
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Cho YE, Kwun IS
- KMID: 2419502
- J Nutr Health.
- 2018 Aug;51(4):316-322.
- doi: 10.4163/jnh.2018.51.4.316
PURPOSE: The Glycyrrhiza uralensis species (Leguminosae) as a medicinal biocompound, and one of its root components, isoliquritigenin (ISL), which is a flavonoid, has been reported to have anti-tumor activity in... -
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- Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells
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Seo HJ, Cho YE, Kim T, Shin HI, Kwun IS
- KMID: 2313466
- Nutr Res Pract.
- 2010 Oct;4(5):356-361.
Zinc is an essential trace element required for bone formation, however not much has been clarified yet for its role in osteoblast. We hypothesized that zinc would increase osteogenetic function... -
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- Molecular mechanisms of hederagenin in bone formation
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Seo HJ, Kwun IS, Kwon J, Sim Y, Cho YE
- KMID: 2537839
- J Nutr Health.
- 2022 Dec;55(6):617-629.
- doi: 10.4163/jnh.2022.55.6.617
Purpose: Osteoporosis is characterized by structural deterioration of the bone tissue because of the loss of osteoblastic activity or the increase in osteoclastic activity, resulting in bone fragility and an... -
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- Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rats
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Cho YE, Lomeda RA, Ryu SH, Sohn HY, Shin HI, Beattie JH, Kwun IS
- KMID: 2313303
- Nutr Res Pract.
- 2007 Jun;1(2):113-119.
Zn is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study evaluated whether Zn... -
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- Issues pertaining to Mg, Zn and Cu in the 2020 Dietary Reference Intakes for Koreans
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Chung HY, Lee MK, Kim W, Choi MK, Kim SH, Kim E, Kim MH, Ha JH, Lee H, Bae YJ, Kwun IS
- KMID: 2530036
- Nutr Res Pract.
- 2022 May;16(S1):s113-s125.
- doi: 10.4162/nrp.2022.16.S1.S113
In the current years, it has now become necessary to establish standards for micronutrient intake based on scientific evidence. This review discusses issues related to the development of the 2020... -
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- Effect of water extract and distillate from the mixture of black goat meat and medicinal herb on osteoblast proliferation and osteoclast formation
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Song HN, Leem KH, Kwun IS
- KMID: 2327186
- J Nutr Health.
- 2015 Apr;48(2):157-166.
- doi: 10.4163/jnh.2015.48.2.157
PURPOSE: The effects of water extract and distillate from the mixture of black goat meat and medicinal herb on MG-63 osteoblast proliferation and mouse bone marrow derived osteoclast formation were... -
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- Macronutrient, Mineral and Vitamin Intakes in Elderly People in Rural Area of North Kyungpook Province in South Korea
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Kwak EH, Lee SL, Yoon JS, Lee HS, Kwon CS, Kwun IS
- KMID: 2269713
- Korean J Nutr.
- 2003 Dec;36(10):1052-1060.
Poor dietary habits and inadequate nutrient intakes are of concern in the elderly, even it is worse in rural areas. In the present study, we conducted the anthropometric measurement and... -
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- Zinc deficiency decreased cell viability both in endothelial EA.hy926 cells and mouse aortic culture ex vivo and its implication for anti-atherosclerosis
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Cho YE, Choi JE, Alam MJ, Lee MH, Sohn HY, Beattie JH, Kwun IS
- KMID: 2313353
- Nutr Res Pract.
- 2008 Jun;2(2):74-79.
Zinc plays a protective role in anti-atherosclerosis but the clear mechanism has not been proposed yet. In the present study, we evaluated whether zinc modulates atherosclerotic markers, VACM-1 and ICAM-1... -
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- Cellular Zn depletion by metal ion chelators (TPEN, DTPA and chelex resin) and its application to osteoblastic MC3T3-E1 cells
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Cho YE, Lomeda RA, Ryu SH, Lee JH, Beattie JH, Kwun IS
- KMID: 2313289
- Nutr Res Pract.
- 2007 Mar;1(1):29-35.
Trace mineral studies involving metal ion chelators have been conducted in investigating the response of gene and protein expressions of certain cell lines but a few had really focused on... -
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