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2020 Dietary Reference Intakes for Koreans: zinc

Lee MK, Kim EM, Kwun IS

This review is focused on analyzing the limits and shortage of zinc (Zn) for the 2020 Dietary Reference Intakes for Koreans (KDRIs), and provides suggestions for the future establishment of...
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Issues pertaining to Mg, Zn and Cu in the 2020 Dietary Reference Intakes for Koreans

Chung HY, Lee MK, Kim W, Choi MK, Kim SH, Kim E, Kim MH, Ha JH, Lee H, Bae YJ, Kwun IS

In the current years, it has now become necessary to establish standards for micronutrient intake based on scientific evidence. This review discusses issues related to the development of the 2020...
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The function of zinc in the primary vascular smooth muscle cell proliferation in rats

Cho YE, Kwun IS

Purpose: The vascular smooth muscle cells (VSMCs) in mature animals have implicated to play a major role in the progression of cardiovascular diseases such as atherosclerosis. This study aimed at...
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Zinc modulation of osterix in MC3T3-E1 cells

Seo HJ, Jeong JB, Cho YE, Kwun IS

Purpose: Zinc is known to be associated with osteoblast proliferation and differentiation. Osterix as zinc-finger transcription factor is also related to osteoblast differentiation and bone formation. In the present study, we...
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Cellular zinc deficiency inhibits the mineralized nodule formation and downregulates bone-specific gene expression in osteoblastic MC3T3-E1 cells

Cho YE, Kwun IS

PURPOSE: Zinc (Zn) is an essential trace element for bone mineralization and osteoblast function. We examined the effects of Zn deficiency on osteoblast differentiation and mineralization in MC3T3-E1 cells. METHODS: Osteoblastic...
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Glycyrrhiza uralensis (licorice) extracts increase cell proliferation and bone marker enzyme alkaline phosphatase activity in osteoblastic MC3T3-E1 cells

Cho YE, Kwun IS

PURPOSE: The Glycyrrhiza uralensis species (Leguminosae) as a medicinal biocompound, and one of its root components, isoliquritigenin (ISL), which is a flavonoid, has been reported to have anti-tumor activity in...
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Zinc upregulates bone-specific transcription factor Runx2 expression via BMP-2 signaling and Smad-1 phosphorylation in osteoblasts

Cho YE, Kwun IS

PURPOSE: Runx2 (runt-related transcription factor 2), a bone-specific transcription factor, is a key regulator of osteoblast differentiation and its expression is induced by the activation of BMP-2 signaling. This study...
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Role of zinc for calcification inhibitor protein in vascular smooth muscle cell plaque formation

Shin MY, Kwun IS

PURPOSE: Zinc, a biomineral present within and outside cells, manages various cellular mechanisms. In this study, we examined whether zinc was involved in vascular smooth muscle cell (VSMC) calcification via...
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Vitamin D: Hormone-like nutrient

Shin MY, Kwun IS

PURPOSE: The aim of this review is to comprehensively summarize the definition of vitamin D as a nutrient as well as a hormone-like molecule and its new function in prevention...
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Effect of water extract and distillate from the mixture of black goat meat and medicinal herb on osteoblast proliferation and osteoclast formation

Song HN, Leem KH, Kwun IS

PURPOSE: The effects of water extract and distillate from the mixture of black goat meat and medicinal herb on MG-63 osteoblast proliferation and mouse bone marrow derived osteoclast formation were...
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Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells

Seo HJ, Cho YE, Kim T, Shin HI, Kwun IS

  • KMID: 2313466
  • Nutr Res Pract.
  • 2010 Oct;4(5):356-361.
Zinc is an essential trace element required for bone formation, however not much has been clarified yet for its role in osteoblast. We hypothesized that zinc would increase osteogenetic function...
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Zinc deficiency decreased cell viability both in endothelial EA.hy926 cells and mouse aortic culture ex vivo and its implication for anti-atherosclerosis

Cho YE, Choi JE, Alam MJ, Lee MH, Sohn HY, Beattie JH, Kwun IS

  • KMID: 2313353
  • Nutr Res Pract.
  • 2008 Jun;2(2):74-79.
Zinc plays a protective role in anti-atherosclerosis but the clear mechanism has not been proposed yet. In the present study, we evaluated whether zinc modulates atherosclerotic markers, VACM-1 and ICAM-1...
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The decreased molar ratio of phytate:zinc improved zinc nutriture in South Koreans for the past 30 years (1969-1998)

Do MS, Lomeda RA, Cho YE, Kwun IS

  • KMID: 2313338
  • Nutr Res Pract.
  • 2007 Dec;1(4):356-362.
For the assessment of representative and longitudinal Zn nutriture in South Koreans, Zn, phytate and Ca intakes were determined using four consecutive years of food consumption data taken from Korean...
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Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rats

Cho YE, Lomeda RA, Ryu SH, Sohn HY, Shin HI, Beattie JH, Kwun IS

  • KMID: 2313303
  • Nutr Res Pract.
  • 2007 Jun;1(2):113-119.
Zn is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study evaluated whether Zn...
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Cellular Zn depletion by metal ion chelators (TPEN, DTPA and chelex resin) and its application to osteoblastic MC3T3-E1 cells

Cho YE, Lomeda RA, Ryu SH, Lee JH, Beattie JH, Kwun IS

  • KMID: 2313289
  • Nutr Res Pract.
  • 2007 Mar;1(1):29-35.
Trace mineral studies involving metal ion chelators have been conducted in investigating the response of gene and protein expressions of certain cell lines but a few had really focused on...
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Effects of Corn Peptide Consumption on Plasma Lipid Profiles in Cholesterol-Fed Rats

Moon MS, Lee JH, Lee MS, Kwun IS, Chung YI, Lee DH, Kim Y

  • KMID: 2270055
  • Korean J Nutr.
  • 2006 Dec;39(8):728-732.
In this study, the effects of corn peptide consumption on plasma lipid profiles were investigated in high cholesterol dietfed rats. Male Sprague-Dawley rats (n = 21) were fed with corn...
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Macronutrient, Mineral and Vitamin Intakes in Elderly People in Rural Area of North Kyungpook Province in South Korea

Kwak EH, Lee SL, Yoon JS, Lee HS, Kwon CS, Kwun IS

  • KMID: 2269713
  • Korean J Nutr.
  • 2003 Dec;36(10):1052-1060.
Poor dietary habits and inadequate nutrient intakes are of concern in the elderly, even it is worse in rural areas. In the present study, we conducted the anthropometric measurement and...
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Relation Dietary and Urinary Na, K, and Ca Level to Blood Pressure in Elderly People in Rural Area

Kwak EH, Lee SL, Lee HS, Kwun IS

  • KMID: 2235859
  • Korean J Nutr.
  • 2003 Jan;36(1):75-82.
It has been considered that high Na intake, and low Ca/K intake are related to the incidence of hypertension. In this preliminary study, dietary Na, K, and Ca intake and...
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