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Pathogenesis of Transplant Glomerulopathy

Lim BJ, Jeong HJ

  • KMID: 2324198
  • J Korean Soc Transplant.
  • 2011 Jun;25(2):71-75.
Transplant glomerulopathy is a late complication of renal transplantation. The characteristic morphology of transplant glomerulopathy includes thickening of glomerular capillary loops with double contour, and duplication of glomerular basement membrane...
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Role of VEGF in Kidney Development, Microvascular Maintenance and Pathophysiology of Renal Disease

Kim BS, Goligorsky MS

  • KMID: 1106138
  • Korean J Intern Med.
  • 2003 Jun;18(2):65-75.
Vascular endothelial growth factor, VEGF, is essential for endothelial cell differentiation (vasculogenesis) and for the sprouting of new capillaries from preexisting vessels (angiogenesis). In addition, there is strong evidence that...
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Changes of glomerular basement membrane components in Vacor-induced diabetic nephropathy

Seon YD, Lee TH, Lee MC

  • KMID: 759088
  • Korean J Intern Med.
  • 1999 Jan;14(1):77-84.
OBJECTIVES: The thickening of the glomerular basement membrane in rats after Vacor ingestion was examined by electron microscopy. This study was performed to elucidate which biochemical components changed...
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Nephron Numbers in Patients with Minimal Change Nephrotic Syndrome (MCNS) and Focal Segmental Glomerulosclerosis (FSGS)

Hwang HH, Yoon BS, Kim KH, Shin SK, Kang EW, Yoo TH, Kie JH

  • KMID: 2307211
  • Korean J Nephrol.
  • 2007 Sep;26(5):548-553.
PURPOSE: It has been proposed that a decreased nephron number may be associated with the increased risk of glomerulosclerosis. In order to test the hypothesis that a reduced number and...
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Thin glomerular basement membrane disease: light microscopic and electron microscopic studies

Suh KS, Kim JO, Kang GH

Benign recurrent hematuria usually indicates a good prognosis. This condition is associated with abnormally thin glomerular basement membranes. Of 680 renal biopsy cases in which lower urinary...
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Crescentic glomerulonephritis: a clinicopathologic analysis of 17 cases with emphasis on glomerular and interstitial neutrophil infiltration

Suh KS, Kim BK, Kim KH

In order to determine the extent to which specific forms of glomerulonephritis (GN) contribute to the pool of crescentic GN, renal tissues from 17 crescentic GN patients were examined with...
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Aberrant Blood Vessel Formation Connecting the Glomerular Capillary Tuft and the Interstitium Is a Characteristic Feature of Focal Segmental Glomerulosclerosis-like IgA Nephropathy

Lim BJ, Kim MJ, Hong SW, Jeong HJ

BACKGROUND: Segmental glomerulosclerosis without significant mesangial or endocapillary proliferation is rarely seen in IgA nephropathy (IgAN), which simulates idiopathic focal segmental glomerulosclerosis (FSGS). We recently recognized aberrant blood vessels running...
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Guillain-Barre like syndrome associated with acute renal failure and thrombocytopenia following acute viral hepatitis A

Lee DK, Do JK, Kim YJ

We reported a 43-year-old woman who showed a Guillain-Barre like syndrome associated with acute renal failure (ARF) and thrombocytopenia following acute viral hepatitis A(HA). The clinical feature was acute...
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Regulation of Glomerular Endothelial Cell Proteoglycans by Glucose

Ha TS, Duraisamy , Faulkner J, Kasinath B

The presence of heparan sulfate proteoglycan (HSPG) in anionic sites in the lamina rara interna of glomerular basement membrane suggests that the proteoglycan may be deposited by the glomerular endothelial...
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TGF-beta Mediated Epithelial-Mesenchymal Transition in Autosomal Dominant Polycystic Kidney Disease

Chea SW, Lee KB

PURPOSE: Recent studies have showed that epithelial-mesenchymal transition (EMT) is a key process of glomerular and tubulointerstitial pathology in many chronic kidney diseases. However, there are no data of EMT...
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Differential Gene Expression According to the Size of Glomeruli in Experimental Diabetic Nephropathy

Kwak SJ, Jung DS, Kim JJ, Li JJ, Han SH, Lee TH, Kim DK, Moon SJ, Han DS, Kang SW

  • KMID: 2254038
  • Korean J Nephrol.
  • 2007 Mar;26(2):137-154.
PURPOSE: Although a few gene-profiling studies with whole renal tissue have been described in experimental diabetic nephropathy, there is only one microarray study using diabetic glomeruli. Furthermore, hypertrophic glomeruli have...
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Experimental Nephritis Induced by Homologous Placental Tissue as Observed with the Light, Fluorescent and Electron Microscope

Lee YW, Lee YB, Kim DS

Toxemia of pregnancy is a common complication of gestation, usually occurring in late pregnancy. Whether toxemia represents an exaggeration of changes incident to pregnancy or depends upon some wholly new...
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Diffuse Glomerular Basement Membrane Lamellation in Post-Transplant IgA Nephropathy

Kwon KW, Hong SW, Kim SI, Kim YS, Park KI, Jeong HJ

Diffuse glomerular basement membrane (GBM) lamellation, reminiscent of Alport's syndrome, has rarely, and exclusively, been reported in renal allografts from pediatric donors to adult recipients. We report on a similar...
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A Case of Light Chain Deposition Disease Involving Kidney and Bone Marrow with Microangiopathic Hemolytic Anemia

Cho YU, Chi HS, Park CJ, Jang S, Cho YM, Park JS

We report a case of light chain deposition disease in a 59-yr-old female showing deposition of monoclonal light chain in the kidney and bone marrow accompanied with a schistocytosis, the...
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Poor renal uptake of technetium-99m-DMSA and technetium-99m-MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate

Kim SE, Cho JT, Lee DS, Chung JK, Kim S, Lee MC, Lee JS, Koh CS

We present a patient with Fanconi syndrome who demonstrated poor renal uptake of 99mTc-DMSA and high urinary concentration of the tracer. A 99mTc-DTPA scan was normal and the creatinine clearance...
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Immunoglobulin A nephropathy in patients with non-insulin dependent diabetes mellitus

Lee EY, Chung CH, Choi SO

The occurrence of immunoglobulin A nephropathy (IgAN) in patients with noninsulin dependent diabetes mellitus (NIDDM) is a rare event and of pathogenetic interest. It is not clear whether this is...
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Protective Effects of Curcumin on Renal Oxidative Stress and Lipid Metabolism in a Rat Model of Type 2 Diabetic Nephropathy

Kim BH, Lee ES, Choi R, Nawaboot J, Lee MY, Lee EY, Kim HS, Chung CH

PURPOSE: Diabetic nephropathy is a serious complication of type 2 diabetes mellitus, and delaying the development of diabetic nephropathy in patients with diabetes mellitus is very important. In this study,...
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Rifampicin-Induced Minimal Change Disease Is Improved after Cessation of Rifampicin without Steroid Therapy

Park DH, Lee SA, Jeong HJ, Yoo TH, Kang SW, Oh HJ

There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In...
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Usefulness of ISN/RPS Classification of Lupus Nephritis

Sada KE, Makino H

About 50-80% of patients with lupus suffer from lupus nephritis which is one of major causes of morbidity and mortality. Renal pathologists and nephrologists should evaluate the degree of histological...
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Smoking-Related Renal Histologic Injury in IgA Nephropathy Patients

Cha YJ, Lim BJ, Kim BS, Kim Y, Yoo TH, Han SH, Kang SW, Choi KH, Jeong HJ

PURPOSE: Smoking reportedly exerts deleterious effects on renal function; however, its effects on histology have not been clarified in patients with IgA nephropathy (IgAN). MATERIALS AND METHODS: Renal histology was evaluated...
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