J Korean Med Sci.  1994 Feb;9(1):29-34. 10.3346/jkms.1994.9.1.29.

Poor renal uptake of technetium-99m-DMSA and technetium-99m-MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate

• Kim SE
• Cho JT
• Lee DS
• Chung JK
• Kim S
• Lee MC
• Lee JS
• Koh CS

• KMID: 1422183
• DOI: http://doi.org/10.3346/jkms.1994.9.1.29

Abstract

We present a patient with Fanconi syndrome who demonstrated poor renal uptake of 99mTc-DMSA and high urinary concentration of the tracer. A 99mTc-DTPA scan was normal and the creatinine clearance only minimally decreased. These findings suggest that 99mTc-DMSA may be accumulated in the kidney by glomerular filtration and subsequent tubular reabsorption, with the nonabsorbed fraction appearing in the urine. In Fanconi Syndrome the tubular reabsorption of DMSA may also be reduced, thus explaining the poor renal uptake in this patient. A 99mTc-MDP bone scan showed faint renal uptake and diffuse high uptake mainly in the spine, demonstrating that the metabolic bone disease associated with Fanconi Syndrome can be another mechanism for poor renal visualization on bone scan.

MeSH Terms

Fanconi Syndrome/*metabolism/radionuclide imaging
Female
Glomerular Filtration Rate
Humans
Kidney/*metabolism/radionuclide imaging
Kidney Glomerulus/*physiology
Middle Aged
Organotechnetium Compounds/*pharmacokinetics
Spine/metabolism/radionuclide imaging
Succimer/*pharmacokinetics
Technetium Tc 99m Dimercaptosuccinic Acid
Technetium Tc 99m Medronate/*pharmacokinetics
Organotechnetium Compounds
Succimer
Technetium Tc 99m Medronate
Technetium Tc 99m Dimercaptosuccinic Acid