Yonsei Med J.  2002 Jun;43(3):395-398. 10.3349/ymj.2002.43.3.395.

Diffuse Glomerular Basement Membrane Lamellation in Post-Transplant IgA Nephropathy

• Kwon KW
• Hong SW
• Kim SI
• Kim YS
• Park KI
• Jeong HJ

• KMID: 1105114
• DOI: http://doi.org/10.3349/ymj.2002.43.3.395

Abstract

Diffuse glomerular basement membrane (GBM) lamellation, reminiscent of Alport's syndrome, has rarely, and exclusively, been reported in renal allografts from pediatric donors to adult recipients. We report on a similar lesion, identified in a 42-year-old male, who received a kidney from an unrelated 21-year-old living male donor. The disease of the recipient was unknown. Renal allograft biopsies were performed 3.5 and 4.8 years after the renal transplantation, due to massive proteinuria and serum creatinine elevation. The histological features of both biopsies were similar, but more advanced in the second biopsy. Glomerular mesangium was widened and had an IgA deposit in the first biopsy. In addition to the presence of mesangial electron dense deposits, the GBM showed diffuse lamellation and splintering on the subepithelial side, but no definite deposits. In the second biopsy, IgA deposits were extended to the peripheral capillary walls, but electron microscopic examination was not available. Two months after the second biopsy, the patient returned for hemodialysis.

Keyword

Allografts; IgA deposit; renal transplantation

MeSH Terms

Adult
Basement Membrane/*pathology
Case Report
Glomerulonephritis, IGA/*etiology/*pathology
Human
Kidney Glomerulus/*pathology
*Kidney Transplantation/*adverse effects
Male