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Neutrophils in Immunity

Woo SY

Neutrophils are the most abundant white blood cells in the peripheral blood and have long been recognized as the major phagocytes in acute infection by destroying extracellular pathogens. Although research...
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Tracing the Variation in Physiological Response to Rifampicin Across the Microbial Spectrum

Dey A, Chatterji

Rifampicin is an acknowledged inhibitor of bacterial RNA polymerase. We observed that there exists a substantial variation in the basal-level tolerance to rifampicin across microbial species. A number of mechanisms...
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Caspase-11, the Main Executioner in Non-canonical Inflammasome

Manzoor Z, Koh YS

Murine caspase-11 is orthologus to human caspase-4 and caspase-5, and is required for the response to cholera toxin B and infection with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. Caspase-11...
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Silver Nanoparticles as a Smart Antimicrobial Agent

Yang EJ, Jang J, Kim S, Choi IH

In modern medicine the resistance to conventional antibiotics is becoming a serious concern due to high instances of mortality. Several metallic nanoparticles are suggested as promising anti-microbial agents against multidrug-resistant...
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Possible Roles of UL112-113 Proteins in Human Cytomegalovirus DNA Replication

Kim YE, Ahn JH

DNA replication of human cytomegalovirus (HCMV) is a highly regulated process that requires specific interactions between cis-acting lytic origin of replication (oriLyt) and trans-acting viral proteins. Formation of the replication...
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Our Genome and Our other Genome: Understanding humans as Symbionts with Microbes

Kim HS

One of the most significant discoveries in life sciences and medicine in recent years is that we humans are symbionts with a large number of microbes. These microbes reside on...
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Potential Therapeutics Against Flaviviruses

Lim PO, Lee TH, Chung KM

Flaviviruses have been important human pathogens after emerging and resurging flavivirus diseases over the past decades. Although effective therapeutic agents are not yet commercially available for use in humans, significant...
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Molecular Typing of Clinical Cryptococcus gattii Isolates in Korea

Hwang SM

Cryptococcus gattii causes life-threatening yeast infection in the pulmonary and central nervous systems of humans and animals, and traditionally has been considered to restrict into the tropical and subtropical areas....
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Genetic Classification and Antimicrobial Resistance of Ureaplasma urealyticum Isolated from Urine

Choi M, Park I

Recently, polymerase chain reaction (PCR)-based methods have been used to reclassify Ureaplasma urealyticum into two independent species (spp.), designating U. parvum and U. urealyticum. In the current study, we aim...
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The Effects of Recombinant Synucleins and Insulin-like Growth Factor 1 on Cancer Cell Migration

Shin W, Kim J

The synuclein family consists of three distinct genes, alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha-synuclein and beta-synuclein are predominately expressed in brain and especially alpha-synuclein is related with Parkinson's disease, Alzheimer's...
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Intracellular Signaling Pathways that Regulate Macrophage Chemokine Expression in Response to Mycobacterium abscessus

Kim TS, Lee HM, Yoo H, Park YK, Jo EK

Mycobacterium abscessus (Mabc) is an emerging human pathogen. Less is known about the host immune response to Mabc than to M. tuberculosis. Here, we examined the intracellular signaling pathways that...
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