J Bacteriol Virol.  2012 Jun;42(2):169-171. 10.4167/jbv.2012.42.2.169.

Caspase-11, the Main Executioner in Non-canonical Inflammasome

• Manzoor Z
• Koh YS

• KMID: 1717688
• DOI: http://doi.org/10.4167/jbv.2012.42.2.169

Abstract

Murine caspase-11 is orthologus to human caspase-4 and caspase-5, and is required for the response to cholera toxin B and infection with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. Caspase-11 rather than caspase-1 is the main offender involved in sepsis. Hence, caspase-11 plays an essential pro-inflammatory role in innate immune response to bacterial infections.

Keyword

Caspase-11; Caspase-1; Sepsis; Inflammasome

MeSH Terms

Bacterial Infections
Cholera Toxin
Citrobacter rodentium
Criminals
Escherichia coli
Humans
Immunity, Innate
Sepsis
Vibrio cholerae
Cholera Toxin

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