J Bacteriol Virol.
2012 Jun;42(2):162-168. 10.4167/jbv.2012.42.2.162.
Possible Roles of UL112-113 Proteins in Human Cytomegalovirus DNA Replication
- Affiliations
-
- 1Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea. jahn@skku.edu
- KMID: 1717687
- DOI: http://doi.org/10.4167/jbv.2012.42.2.162
Abstract
- DNA replication of human cytomegalovirus (HCMV) is a highly regulated process that requires specific interactions between cis-acting lytic origin of replication (oriLyt) and trans-acting viral proteins. Formation of the replication initiation complex is also regulated by specific interactions among viral replication proteins. HCMV replication proteins include origin-binding proteins, core proteins that work in replication forks, and regulatory proteins that modulate host cell functions. This letter describes intriguing questions regarding how HCMV origin-binding proteins interact with oriLyt to initiate DNA replication and how the regulatory UL112-113 proteins, which are found only in beta-herpesviruses, function to promote viral DNA replication.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Genome Architecture and Its Roles in Human Copy Number Variation
- Detection of human cytomegalovirus DNA polymerase gene by polymerase chain reaction
- Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types
- Differential Regulation of NF-kappaB Signaling during Human Cytomegalovirus Infection
- Kidneys with bad ends
