J Bacteriol Virol.  2012 Jun;42(2):87-100. 10.4167/jbv.2012.42.2.87.

Tracing the Variation in Physiological Response to Rifampicin Across the Microbial Spectrum

• Dey A
• Chatterji

• KMID: 1717680
• DOI: http://doi.org/10.4167/jbv.2012.42.2.87

Abstract

Rifampicin is an acknowledged inhibitor of bacterial RNA polymerase. We observed that there exists a substantial variation in the basal-level tolerance to rifampicin across microbial species. A number of mechanisms have come to light which depict the molecular aspects of the behavior of an individual bacterial cell towards rifampicin. This review assesses the current knowledge about rifampicin and conjectures about the probable aspects of rifampicin which remain unexplored.

Keyword

RNA polymerase; Rifampicin; Antibiotic resistance

MeSH Terms

DNA-Directed RNA Polymerases
Drug Resistance, Microbial
Light
Rifampin
RNA, Bacterial
DNA-Directed RNA Polymerases
RNA, Bacterial
Rifampin