- Economic Evaluation of Iron Chelation Agents: Oral Deferasirox versus Infusional Deferoxamine
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Kim JH, Kim YH
- KMID: 2252201
- Korean J Hematol.
- 2008 Jun;43(2):89-97.
- doi: 10.5045/kjh.2008.43.2.89
BACKGROUND: Patients with transfusional iron overload have relied on treatment with deferoxamine, a standard chelating agent. Deferoxamine is administered by intravenous or subcutaneous infusion over an 8~12 hour period 5~7... -
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- Comparison of Immune Responses Induced by Deferoxamine and Deferasirox
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Jung YS, Bae EY, Chung NG, Cho B, Kim HK, Min CK, Han CW, Kim HS, Jeong DC
- KMID: 2252181
- Korean J Hematol.
- 2008 Sep;43(3):150-158.
- doi: 10.5045/kjh.2008.43.3.150
BACKGROUND: The iron chelating agents (ICA) have various biological effects besides iron chelation. We investigated the immunomodulatory effects of Deferasirox (DFS) compared to Deferoxamine (DFO). METHODS: Spleen cells (SP) were obtained... -
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- Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
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Park EH, Lee HJ, Lee SY, Kim SY, Yi HK, Lee DY, Hwang PH
- KMID: 2281678
- Korean J Pediatr.
- 2009 Feb;52(2):213-219.
- doi: 10.3345/kjp.2009.52.2.213
PURPOSE: Iron is a critical nutritional element that is essential for a variety of important biological processes, including cell growth and differentiation, electron transfer reactions, and oxygen transport, activation, and... -
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- Guanosine 5′-monophosphate-chelated calcium and iron feed additives maintains egg production and prevents Salmonella Gallinarum in experimentally infected layers
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Noh HJ, Kim H, Heo SJ, Cho HH, Koh HB
- KMID: 2412446
- J Vet Sci.
- 2017 Sep;18(3):291-97.
- doi: 10.4142/jvs.2017.18.3.291
We evaluated the effects of guanosine 5′-monophosphate (GMP)-chelated calcium and iron (CaFe-GMP) on health and egg quality in layers experimentally infected with Salmonella Gallinarum. In this study, a CaFe-GMP feed... -
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- Effect of Iron-Chelator Deferiprone on the In Vitro Growth of Staphylococci
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Kim CM, Shin SH
- KMID: 1779132
- J Korean Med Sci.
- 2009 Apr;24(2):289-295.
- doi: 10.3346/jkms.2009.24.2.289
The standard iron-chelator deferoxamine is known to prevent the growth of coagulase-negative staphylococci (CoNS) which are major pathogens in iron-overloaded patients. However, we found that deferoxamine rather promotes the growth... -
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- Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload
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Jang JH, Lee JH, Yoon SS, Jo DY, Kim HJ, Chung J, Lee JW
- KMID: 1777651
- J Korean Med Sci.
- 2013 Nov;28(11):1563-1572.
- doi: 10.3346/jkms.2013.28.11.1563
Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an... -
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- Three Cases of Superficial Siderosis
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Kim BG, Roh JK, Jeon BS, Han MH
- KMID: 2342574
- J Korean Neurol Assoc.
- 1996 Sep;14(3):848-854.
Superficial siderosis is a rare condition characterized by hemosiderin deposition in leptomeninges, subpial tissue, brainstem, cerebellum, spinal cord, and cranial nerves. Slowly progressive hearing loss and gait ataxia are invariable... -
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- Recent advances in treatment of aplastic anemia
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Shin SH, Lee SE, Lee JW
- KMID: 2070127
- Korean J Intern Med.
- 2014 Nov;29(6):713-726.
- doi: 10.3904/kjim.2014.29.6.713
Recent advances in the treatment of aplastic anemia (AA) made most of patients to expect to achieve a long-term survival. Allogeneic stem cell transplantation (SCT) from HLA-matched sibling donor (MSD-SCT)... -
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- Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
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Kim DS, Na YJ, Kang MH, Yoon SY, Choi CW
- KMID: 2373811
- Korean J Intern Med.
- 2016 Mar;31(2):357-366.
- doi: 10.3904/kjim.2015.024
BACKGROUND/AIMS: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed,... -
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- Diagnostic and Therapeutic Approach for Acute Paraquat Intoxication
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Gil HW, Hong JR, Jang SH, Hong SY
- KMID: 2069922
- J Korean Med Sci.
- 2014 Nov;29(11):1441-1449.
- doi: 10.3346/jkms.2014.29.11.1441
Paraquat (PQ) has known negative human health effects, but continues to be commonly used worldwide as a herbicide. Our clinical data shows that the main prognostic factor is the time... -
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- Complete Hematopoietic Recovery after Continuous Iron Chelation Therapy in a Patient with Severe Aplastic Anemia with Secondary Hemochromatosis
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Park SJ, Han CW
- KMID: 1713468
- J Korean Med Sci.
- 2008 Apr;23(2):320-323.
- doi: 10.3346/jkms.2008.23.2.320
A 16-yr-old male patient with hemochromatosis due to multiple packed red blood cell transfusions was referred to our emergency center for the treatment of severe aplastic anemia and dyspnea. He... -
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- Cost Analysis of Iron-Related Complications in a Single Institute
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Kim KH, Kim JW, Rhee JY, Kim MK, Kim BS, Kim I, Bang SM, Yoon SS, Lee JS, Han KS, Park S, Kim BK
- KMID: 1785639
- Korean J Intern Med.
- 2009 Mar;24(1):33-36.
- doi: 10.3904/kjim.2009.24.1.33
BACKGROUND/AIMS: The financial burden of caring for iron-related complications (IRCs) is an emerging medical problem in Korea, as in Western countries. We produced a preliminary estimate of the costs... -
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- Iron Overload during Follow-up after Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Patients with High-Risk Neuroblastoma
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Bae SJ, Kang C, Sung KW, Chueh HW, Son MH, Lee SH, Yoo KH, Koo HH
- KMID: 2157895
- J Korean Med Sci.
- 2012 Apr;27(4):363-369.
- doi: 10.3346/jkms.2012.27.4.363
Multiple RBC transfusions inevitably lead to a state of iron overload before and after high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT). Nonetheless, iron status during post-SCT follow-up remains unknown.... -
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- Iron chelator inducesMIP-3alpha/CCL20 in human intestinal epithelial cells: implication for triggeringmucosal adaptive immunity
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Lee HJ, Choi SC, Choi EY, Lee MH, Seo GS, Kim EC, Yang BJ, Lee MS, Shin YI, Park KI, Jun CD
- KMID: 1093465
- Exp Mol Med.
- 2005 Aug;37(4):297-310.
A previous report by this laboratory demonstrated that bacterial iron chelator (siderophore) triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs). Microarray-based gene... -
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