- Inhibition of Class I Histone Deacetylase Enhances Self-Reprogramming of Spermatogonial Stem Cells into Pluripotent Stem Cells
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Lee Y, Lee SW, Jeong D, Lee HJ, Choi NY, Bang JS, Ham S, Ko K
- KMID: 2539618
- Int J Stem Cells.
- 2023 Feb;16(1):27-35.
- doi: 10.15283/ijsc22110
Background and Objectives: Spermatogonial stem cells (SSCs) are the most primitive cells in spermatogenesis and are the only adult stem cells capable of passing on the genome of a given... -
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- Lymphoid Lineage γδ T Cells Were Successfully Generated from Human Pluripotent Stem Cells via Hemogenic Endothelium
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Jeon SB, Han AR, Choi YB, Lee AR, Lee JY
- KMID: 2539625
- Int J Stem Cells.
- 2023 Feb;16(1):108-116.
- doi: 10.15283/ijsc22150
γδ T cells are a rare and unique prototype of T cells that share properties with natural killer cells in secondary lymphoid organs. Although many studies have revealed the function... -
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- Embryonic Stem Cells Lacking DNA Methyltransferases Differentiate into Neural Stem Cells that Are Defective in Self-Renewal
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Seo BJ, Hong TK, Yoon SH, Song JH, Uhm SJ, Song H, Hong K, Schöler HR, Do JT
- KMID: 2539620
- Int J Stem Cells.
- 2023 Feb;16(1):44-51.
- doi: 10.15283/ijsc22138
Background and Objectives: DNA methyltransferases (Dnmts) play an important role in regulating DNA methylation during early developmental processes and cellular differentiation. In this study, we aimed to investigate the role... -
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- In Vitro Generation of Luminal Vasculature in Liver Organoids: From Basic Vascular Biology to Vascularized Hepatic Organoids
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Kim HJ, Kim G, Chi KY, Kim JH
- KMID: 2539616
- Int J Stem Cells.
- 2023 Feb;16(1):1-15.
- doi: 10.15283/ijsc22154
Liver organoids have gained much attention in recent years for their potential applications to liver disease modeling and pharmacologic drug screening. Liver organoids produced In Vitro reflect some aspects of... -
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- Tracking of Stem Cells from Human Exfoliated Deciduous Teeth Labeled with Molday ION Rhodamine-B during Periodontal Bone Regeneration in Rats
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Zhang N, Xu L, Song H, Bu C, Kang J, Zhang C, Yang X, Han F
- KMID: 2539624
- Int J Stem Cells.
- 2023 Feb;16(1):93-107.
- doi: 10.15283/ijsc21204
Background and Objectives: Chronic periodontitis can lead to alveolar bone resorption and eventually tooth loss. Stem cells from exfoliated deciduous teeth (SHED) are appropriate bone regeneration seed cells. To track... -
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- Reduced Cytotoxicity by Repetitive mRNA Transfection in Differentiated Neurons
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Ko SH, Kang JS, Kim SM, Lee EH, Park CH
- KMID: 2539626
- Int J Stem Cells.
- 2023 Feb;16(1):117-122.
- doi: 10.15283/ijsc22125
Background and Objectives: mRNA-based protein expression technology has been used to express functional proteins. We have previously generated dopamine neurons from rat-embryo derived neural precursor cells (NPCs) through repeated transfection... -
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- Synergistic Effect of Hydrogen and 5-Aza on Myogenic Differentiation through the p38 MAPK Signaling Pathway in Adipose-Derived Mesenchymal Stem Cells
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Fei W, Pang E, Hou L, Dai J, Liu M, Wang X, Xie B, Wang J
- KMID: 2539623
- Int J Stem Cells.
- 2023 Feb;16(1):78-92.
- doi: 10.15283/ijsc21238
Background and Objectives: This study aims to clarify the systems underlying regulation and regulatory roles of hydrogen combined with 5-Aza in the myogenic differentiation of adipose mesenchymal stem cells (ADSCs). Methods... -
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- Generation of Induced Pluripotent Stem Cells from Lymphoblastoid Cell Lines by Electroporation of Episomal Vectors
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Kim M, Park J, Kim S, Han DW, Shin B, Schöler HR, Kim J, Kim KP
- KMID: 2539619
- Int J Stem Cells.
- 2023 Feb;16(1):36-43.
- doi: 10.15283/ijsc22177
Background and Objectives: Lymphoblastoid cell lines (LCLs) deposited from disease-affected individuals could be a valuable donor cell source for generating disease-specific induced pluripotent stem cells (iPSCs). However, generation of iPSCs... -
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- Establishing Rationale for the Clinical Development of Cell Therapy Products: Consensus between Risk and Benefit
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Han S, Yim HW, Jeong H, Choi S, Han S
- KMID: 2539617
- Int J Stem Cells.
- 2023 Feb;16(1):16-26.
- doi: 10.15283/ijsc21189
Despite long-term research achievements, the development of cell therapy (CT) products remains challenging. This is because the risks experienced by the subject and therapeutic effects in the clinical trial stage... -
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- Efficacy and Safety of Human Bone Marrow-Derived Mesenchymal Stem Cells according to Injection Route and Dose in a Chronic Kidney Disease Rat Model
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Chae HK, Suh N, Jang MJ, Kim YS, Kim BH, Aum J, Shin HC, You D, Hong B, Park HK, Kim CS
- KMID: 2539622
- Int J Stem Cells.
- 2023 Feb;16(1):66-77.
- doi: 10.15283/ijsc21146
Background and Objectives: We compared the efficacy and safety of human bone marrow-derived mesenchymal stem cells (hBMSC), delivered at different doses and via different injection routes in an animal model... -
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- Mesenchymal Stem Cells Ameliorate Fibrosis by Enhancing Autophagy via Inhibiting Galectin-3/Akt/mTOR Pathway and by Alleviating the EMT via Inhibiting Galectin-3/Akt/GSK3β/Snail Pathway in NRK-52E Fibrosis
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Zhao Y, Guo C, Zeng L, Li J, Liu X, Wang Y, Zhao K, Chen B
- KMID: 2539621
- Int J Stem Cells.
- 2023 Feb;16(1):52-65.
- doi: 10.15283/ijsc22014
Background and Objectives: Epithelial-Mesenchymal transition (EMT) is one of the origins of myofibroblasts in renal interstitial fibrosis. Mesenchymal stem cells (MSCs) alleviating EMT has been proved, but the concrete mechanism... -
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