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Adipose Tissue-Derived Stem Cells from Type 2 Diabetics Reveal Conservative Alterations in Multidimensional Characteristics

Wang L, Zhang L, Liang X, Zou J, Liu N, Liu T, Wang G, Ding X, Liu Y, Zhang B, Liang R, Wang S

Background and Objectives: Adipose tissue-derived mesenchymal stem cells (ASCs) are recognized as an advantaged source for the prevention and treatment of diverse diseases including type 2 diabetes mellitus (T2DM). However,...
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Effect of Conditioned Medium from Human Umbilical Cord-Derived Mesenchymal Stromal Cells on Rejuvenation of Nucleus Pulposus Derived Stem/Progenitor Cells from Degenerated Intervertebral Disc

Zeng X, Lin J, Wu H, Yu J, Tu M, Cheang LH, Zhang J

Background and Objectives: Mesenchymal stromal cells (MSCs)-based treatment for degeneration of intervertebral disc (IVD) has been proposed recently. We here addressed whether MSC secreted factors can rejuvenate nucleus pulposus- derived...
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Overexpression of p21 Has Inhibitory Effect on Human Hematopoiesis by Blocking Generation of CD43+ Cells via Cell-Cycle Regulation

Zeng J, Zhang H, Liu Y, Sun W, Yi D, Zhu L, Zhang Y, Pan X, Chen Y, Zhou Y, Bian G, Lai M, Zhou Q, Liu J, Chen B, Ma F

Background and Objectives: p21, an important member of the Cip/Kip family, is involved in inhibitory effects of RUNX1b overexpression during the early stage of human hematopoiesis. Methods and Results: We established...
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The Distinct Role of Tcfs and Lef1 in the Self-Renewal or Differentiation of Mouse Embryonic Stem Cells

Kim S, Kim H, Tan A, Song Y, Lee H, Ying QL, Jho Eh

Background and Objectives: Tcfs and Lef1 are DNA-binding transcriptional factors in the canonical Wnt signaling pathway. In the absence of β-catenin, Tcfs and Lef1 generally act as transcriptional repressors with...
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The Role of Lysophosphatidic Acid in Adult Stem Cells

Lee D, Kim YH, Kim JH

Stem cells are undifferentiated multipotent precursor cells that are capable both of perpetuating themselves as stem cells (self-renewal) and of undergoing differentiation into one or more specialized types of cells....
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Regenerative Therapy for Osteoarthritis: A Perspective

Im GI, Kim TK

Osteoarthritis (OA) is the most common type of arthritis and causes a significant deterioration in patients’ quality of life. The high prevalence of OA as well as the current lack...
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Effect of Cell Labeling on the Function of Human Pluripotent Stem Cell-Derived Cardiomyocytes

Choi SW, Cho YW, Kim JG, Kim YJ, Kim E, Chung HM, Kang SW

Cell labeling technologies are required to monitor the fate of transplanted cells in vivo and to select target cells for the observation of certain changes in vitro. Human induced pluripotent...
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Long-Term Expansion of Functional Human Pluripotent Stem Cell-Derived Hepatic Organoids

Mun SJ, Hong YH, Ahn HS, Ryu JS, Chung KS, Son MJ

A human cell-based liver model capable of long-term expansion and mature hepatic function is a fundamental requirement for pre-clinical drug development. We previously established self-renewing and functionally mature human pluripotent...
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Proliferation, Differentiation and Immunoregulatory Capacities of Brown and White Adipose-Derived Stem Cells from Young and Aged Mice

Yang YM, Dong XH, Ma WC, Guan LH, Wang YH, Huang XH, Chen JF, Zhao X, Yang SM, Jiang XX, Wen N

Background and Objectives: Adipose tissue is a source of mesenchymal stem cells, which have the potential to differentiate into various types of cells. Adipose-derived stem cells (ADSCs) are now recognized...
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SOCS1 Regulates the Immunomodulatory Roles of MSCs on B Cells

Zhang L, Qu YN, Zhang HY, Wu ZY, Li ZL, Guo WB, Wang QB, Fang NZ, Jiang XX

Background and Objectives: The effective use of MSCs for the treatment of some B cell-mediated immune diseases is quite limited. The main reason is that the immunomodulatory effects of mesenchymal...
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Intratracheal Transplantation of Amnion-Derived Mesenchymal Stem Cells Ameliorates Hyperoxia-Induced Neonatal Hyperoxic Lung Injury via Aminoacyl-Peptide Hydrolase

Li Z, Gong X, Li D, Yang X, Shi Q, Ju X

Background and Objectives: Bronchopulmonary dysplasia (BPD) has major effects in premature infants. Although previous literature has indicated that mesenchymal stem cells (MSCs) can alleviate lung pathology in BPD newborns and...
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Human Amniotic Epithelial Cells Affect the Functions of Neutrophils

Alipour R, Motedayyen H, Sereshki N, Rafiee M, Alsahebfosul F, Pourazar A

Background and Objectives: As a stem cell group, Human amniotic epithelial cells (HAECs) have numerous advantages over their embryonic and adult counterparts for therapeutic utility. They are closer to clinical...
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