- Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1
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Song Y, Lee S, Kim JR, Jho EH
- KMID: 2429557
- Int J Stem Cells.
- 2018 Nov;11(2):242-247.
- doi: 10.15283/ijsc18032
Ubiquitination of proteins plays an essential role in various cellular processes, including protein degradation, DNA repair, and cell signaling pathways. Previous studies have shown that protein ubiquitination is implicated in... -
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- Immunomodulatory Effects of Placenta-derived Mesenchymal Stem Cells on T Cells by Regulation of FoxP3 Expression
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Kim SH, Jung J, Cho KJ, Choi JH, Lee HS, Kim GJ, Lee SG
- KMID: 2429552
- Int J Stem Cells.
- 2018 Nov;11(2):196-204.
- doi: 10.15283/ijsc18031
The immunomodulatory effects of mesenchymal stem cells (MSCs) are an important mediator of their therapeutic effects in stem cell therapy and regenerative medicine. The regulation mechanism of MSCs is orchestrated... -
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- Improved Transfection Efficiency and Metabolic Activity in Human Embryonic Stem Cell Using Non-Enzymatic Method
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Kim CY, Hwang IK, Kang C, Chung EB, Jung CR, Oh H, Jeong YH, Moon SH, Kim JS, Hong KS, Park JH, Chung HM
- KMID: 2429547
- Int J Stem Cells.
- 2018 Nov;11(2):149-156.
- doi: 10.15283/ijsc18037
Human embryonic stem cells (hESCs) are pluripotent cells widely used in conventional and regenerative medicine due to their ability to self-renew, proliferate and differentiate. Recently, genetic modification of stem cells... -
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- Mbd3 Promotes Reprogramming of Primary Human Fibroblasts
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Jaffer S, Goh P, Abbasian M, Nathwani A
- KMID: 2429556
- Int J Stem Cells.
- 2018 Nov;11(2):235-241.
- doi: 10.15283/ijsc18036
Mbd3 (Methyl-CpG binding domain protein), a core member of NuRD (nucleosome remodelling and deacetylation) is essential for embryogenesis. However, its role in reprogramming of somatic cells into induced pluripotent stem... -
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- The Pharmacological Inhibition of ERK5 Enhances Apoptosis in Acute Myeloid Leukemia Cells
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Kang C, Kim JS, Kim CY, Kim EY, Chung HM
- KMID: 2429555
- Int J Stem Cells.
- 2018 Nov;11(2):227-234.
- doi: 10.15283/ijsc18053
Acute myeloid leukemia (AML) is a fatal hematological malignancy which is resistant to a variety of chemotherapy drugs. Extracellular signal-regulated kinase 5 (ERK5) plays a novel role in chemoresistance in... -
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- Olig2-expressing Mesenchymal Stem Cells Enhance Functional Recovery after Contusive Spinal Cord Injury
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Park HW, Oh S, Lee KH, Lee BH, Chang MS
- KMID: 2429550
- Int J Stem Cells.
- 2018 Nov;11(2):177-186.
- doi: 10.15283/ijsc18071
BACKGROUND AND OBJECTIVES: Glial scarring and inflammation after spinal cord injury (SCI) interfere with neural regeneration and functional recovery due to the inhibitory microenvironment of the injured spinal cord. Stem... -
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- MiR-9 Controls Chemotactic Activity of Cord Blood CD34⺠Cells by Repressing CXCR4 Expression
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Ha TW, Kang HS, Kim TH, Kwon JH, Kim HK, Ryu A, Jeon H, Han J, Broxmeyer , Hwang Y, Lee YK, Lee MR
- KMID: 2429551
- Int J Stem Cells.
- 2018 Nov;11(2):187-195.
- doi: 10.15283/ijsc18057
Improved approaches for promoting umbilical cord blood (CB) hematopoietic stem cell (HSC) homing are clinically important to enhance engraftment of CB-HSCs. Clinical transplantation of CB-HSCs is used to treat a... -
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- Effect of Stem Cells and Gene Transfected Stem Cells Therapy on the Pancreas of Experimentally Induced Type 1 Diabetes
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Zickri MB, Aboul-Fotouh GI, Omar AI, El-Shafei , Reda AM
- KMID: 2429553
- Int J Stem Cells.
- 2018 Nov;11(2):205-215.
- doi: 10.15283/ijsc18002
BACKGROUND AND OBJECTIVES: Insulin secretion entirely depends on Ca²⺠influx and sequestration into endoplasmic reticulum (ER) of β-cells, performed by Sarco-ER Ca²âº-ATPase 2b (SERCA2b). In diabetes, SERCA2b is decreased in... -
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- Comparative Study on Acellular Dermal Graft Versus Propylene Mesh Both Either Loaded or Unloaded with BM-MSCs in Healing of Skull Bone Defect in Rats: Histological and Immunohistochemical Study
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Elkhateb L, Zohdy A, Atalla SS, Moussa MH, Hamam GG, Zahra FA
- KMID: 2429554
- Int J Stem Cells.
- 2018 Nov;11(2):216-226.
- doi: 10.15283/ijsc18019
Bone defect occurs as a consequence of many conditions. Diseased bones don’t heal properly and defects in face area need proper bone reconstruction to avoid psychological and social problems. Tissue... -
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- rBMSCs/ITGA5B1 Promotes Human Vascular Smooth Muscle Cell Differentiation via Enhancing Nitric Oxide Production
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Zhang Y, Ding J, Xu C, Yang H, Xia P, Ma S, Chen H
- KMID: 2429549
- Int J Stem Cells.
- 2018 Nov;11(2):168-176.
- doi: 10.15283/ijsc18079
BACKGROUND AND OBJECTIVES: Previous studies have shown that integrins alpha5beta1 (ITGA5B1) gene-modified rat bone marrow mesenchymal stem cells (rBMSCs) could prevent cell anoikis and increase the nitric oxide (NO) production.... -
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- Hypoxic Preconditioned Mesenchymal Stromal Cell Therapy in a Rat Model of Renal Ischemia-reperfusion Injury: Development of Optimal Protocol to Potentiate Therapeutic Efficacy
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Jang MJ, You D, Park JY, Kim K, Aum J, Lee C, Song G, Shin HC, Suh N, Kim YM, Kim CS
- KMID: 2429548
- Int J Stem Cells.
- 2018 Nov;11(2):157-167.
- doi: 10.15283/ijsc18073
Although previous and ongoing clinical studies have used stromal cells during renal ischemia-reperfusion injury (IRI), there is little consensus regarding the optimal protocol. We aimed to optimize the protocol for... -
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