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Calcium Signaling in Salivary Secretion

Kim JM, Lee SW, Park K

Calcium has versatile roles in diverse physiological functions. Among these functions, intracellular Ca²⁺ plays a key role during the secretion of salivary glands. In this review, we introduce the diverse...
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The effect of Ni2+ on the intracellular Ca2+ increase of the mouse early 2-cell embryos

Yoon SY, Lee EM, Bae IH

  • KMID: 2304560
  • Korean J Fertil Steril.
  • 2003 Dec;30(4):269-280.
OBJECTIVE: We reported the overcoming effect of Ni2+ on the in vitro 2-cell block of mouse embryos. In this study, we aim to investigate whether Ni2+ should induce intracellular Ca2+...
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Effects of Inositol 1,4,5-triphosphate on Osteoclast Differentiation in RANKL-induced Osteoclastogenesis

Son A, Kim MS, Jo H, Byun HM, Shin DM

The receptor activator of NF-kappaB ligand (RANKL) signal is an activator of tumor necrosis factor receptor-associated factor 6 (TRAF6), which leads to the activation of NF-kappaB and other signal transduction...
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Peptidoglycan Induces the Production of Interleukin-8 via Calcium Signaling in Human Gingival Epithelium

Son A, Shin DM, Hong JH

The etiology of periodontal disease is multifactorial. Exogenous stimuli such as bacterial pathogens can interact with toll-like receptors to activate intracellular calcium signaling in gingival epithelium and other tissues. The...
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The Transcription Factor Mist1 Regulates the Cellular Polarity in Mouse Pancreatic Acinar Cells

Yang YM, Lee SI, Shin DM

  • KMID: 2009498
  • Int J Oral Biol.
  • 2012 Mar;37(1):37-41.
Pancreatic acinar cells exhibit a polarity that is characterized by the localization of secretory granules at the apical membrane. However, the factors that regulate cellular polarity in these cells are...
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Caffeine and 2-Aminoethoxydiphenyl Borate (2-APB) Have Different Ability to Inhibit Intracellular Calcium Mobilization in Pancreatic Acinar Cell

Choi KJ, Kim KS, Kim SH, Kim DK, Park HS

Inositol 1,4,5-trisphosphate receptors (InsP3Rs) modulate Ca2+ release from intracellular Ca2+ store and are extensively expressed in the membrane of endoplasmic/sarcoplasmic reticulum and Golgi. Although caffeine and 2-aminoethoxydiphenyl borate (2-APB) have...
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Mercury Promotes Catecholamines Which Potentiate Mercurial Autoimmunity and Vasodilation: Implications for Inositol 1,4,5-Triphosphate 3-Kinase C Susceptibility in Kawasaki Syndrome

Yeter D, Deth R, Kuo HC

Previously, we reviewed biological evidence that mercury could induce autoimmunity and coronary arterial wall relaxation as observed in Kawasaki syndrome (KS) through its effects on calcium signaling, and that inositol...
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The Effect Erythrocyte lysate on Intracellular Calcium Concentration and the Potassium Channel in Cerebral Vasular Smooth Muscle Cells

Kim CJ

  • KMID: 2010253
  • J Korean Neurosurg Soc.
  • 1997 Dec;26(12):1644-1652.
Erythrocyte lysate increases intracellular Ca2+[Ca2+]i, causes contraction in cerebral arteries, and is thought to be the causative agent in cerebral vasospasm ; the mechanism of erythrocyte lysate-induced [Ca2+]i...
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Distinct Cellular Calcium Metabolism in Radiation-sensitive RKO Human Colorectal Cancer Cells

Kim YT, Jo SS, Park YJ, Lee MZ, Suh CK

Radiation therapy for variety of human solid tumors utilizes mechanism of cell death after DNA damage caused by radiation. In response to DNA damage, cytochrome c was released from mitochondria...
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The Effect of IP3 Receptor Inhibition Using 2-APB on Gentamicin Ototoxicity in Cochlear Sensory Cell

Moon JH, Jung JY, Ahn JC, Seong YS, Lim ES, Rhee CK

  • KMID: 2276746
  • Korean J Otolaryngol-Head Neck Surg.
  • 2007 May;50(5):385-390.
BACKGROUND AND OBJECTIVES: Elevated intracellular calcium level is known to play important roles in the apoptotic pathway. IP3 receptor (ligand-gated channels that release Ca2+ from intracellular stores) is emerging as...
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Effects of Reactive Oxygen Species on ATP-induced intracellular Ca2+ Activity in Osteoblasts

Kim JH, Kwon TD, Nam SH, Suh CK, Hong YW

BACKGORUND: The physiological activity of osteoblsts is known to be closely related to increased intracellular Ca2+ activity ([Ca2+ ]i) in osteoblasts. The cellular regulation of ([Ca2+ ]i) in osteoblasts...
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Properties of spontaneous activity in gastric smooth muscle

Suzuki H, Yamamoto Y, Hirst G

  • KMID: 1554124
  • Korean J Physiol Pharmacol.
  • 1999 Apr;3(2):119-125.
Mammalian gastric smooth muscles generate spontaneous rhythmic contractions which are associated with slow oscillatory potentials (slow waves) and spike potentials. Spike potentials are blocked by organic Ca2+-antagonists, indicating that these result from the activation...
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Alteration of Expression of Ca(2+) Signaling Proteins and Adaptation of Ca(2+) Signaling in SERCA2(+/-) Mouse Parotid Acini

Choi JH, Jo H, Hong JH, Lee SI, Shin DM

PURPOSE: The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), encoded by ATP2A2, is an essential component for G-protein coupled receptor (GPCR)-dependent Ca(2+) signaling. However, whether the changes in Ca(2+) signaling and Ca(2+) signaling...
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