J Korean Dent Sci.
2017 Dec;10(2):45-52. 10.5856/JKDS.2017.10.2.45.
Calcium Signaling in Salivary Secretion
- Affiliations
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- 1Department of Physiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea. kppark@snu.ac.kr
- KMID: 2405561
- DOI: http://doi.org/10.5856/JKDS.2017.10.2.45
Abstract
- Calcium has versatile roles in diverse physiological functions. Among these functions, intracellular Ca²âº plays a key role during the secretion of salivary glands. In this review, we introduce the diverse cellular components involved in the saliva secretion and related dynamic intracellular Ca²âº signals. Calcium acts as a critical second messenger for channel activation, protein translocation, and volume regulation, which are essential events for achieving the salivary secretion. In the secretory process, Ca²âº activates K⺠and Clâ» channels to transport water and electrolyte constituting whole saliva. We also focus on the Ca²âº signals from intracellular stores with discussion about detailed molecular mechanism underlying the generation of characteristic Ca²âº patterns. In particular, inositol triphosphate signal is a main trigger for inducing Ca²âº signals required for the salivary gland functions. The biphasic response of inositol triphosphate receptor and Ca²âº pumps generate a self-limiting pattern of Ca²âº efflux, resulting in Ca²âº oscillations. The regenerative Ca²âº oscillations have been detected in salivary gland cells, but the exact mechanism and function of the signals need to be elucidated. In future, we expect that further investigations will be performed toward better understanding of the spatiotemporal role of Ca²âº signals in regulating salivary secretion.
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