J Oral Med Pain.  2023 Jun;48(2):39-44. 10.14476/jomp.2023.48.2.39.

Role of Homeostatic Changes in Salivary Gland Acinar Cells in Primary Sjöögren's Syndrome: A Review

• Byun JS

• KMID: 2552137
• DOI: http://doi.org/10.14476/jomp.2023.48.2.39

Abstract

Primary Sjögren's syndrome (pSS) is an autoimmune progressive disease characterized by dysfunction and inflammation of the salivary glands. The underlying mechanisms of salivary gland involvement in pSS remain unclear, and researchers have primarily focused on immunological phenomena, making it difficult to distinguish between the cause and effect of the disease. Consequently, our research aims to directly investigate changes in homeostasis occurring in acinar cells, specifically in the context of muscarinic signaling, mucins, aquaporins, and forkhead box protein O1, to elucidate the initial step of pSS. We compare the disease-related phenomena observed in salivary gland acinar cells in pSS with the overall process of salivary secretion.

Keyword

Aquaporins; Forkhead box protein O1; Mucins; Muscarinic signaling; Primary Sjögren’s syndrome; Salivary gland acinar cells