Anat Biol Anthropol.  2019 Sep;32(3):83-91. 10.11637/aba.2019.32.3.83.

Application of Developmental Principles for Functional Regeneration of Salivary Glands

• Lee ES
• Adhikari N
• Jung JK
• An CH
• Kim JY
• Kim JY

• KMID: 2459066
• DOI: http://doi.org/10.11637/aba.2019.32.3.83

Abstract

Currently, there has been rapid increase in the studies about salivary production because of the hyposalivation, xerostomia, caused by radiotherapy for head and neck cancer, Sjogren syndrome and aging. An overview of anatomy and development of salivary gland is crucial to understand about the patho-physiological disorders related with saliva. For study of the morphogenesis and development of salivary glands, experiment using rodent models is widely necessary. This review wraps up the early to latest studies - the different features of each salivary gland, morphogenesis of developing salivary glands, and the comparison of human and rodent salivary glands. The goal of this review is to provide hypothesis for the further researches about differentiation of specific acinar cells, from which it is determined to be specific acini. Additionally, we discuss approaches to regenerate the function of salivary glands using environmental factor, time dependent factor and nerve factor.

Keyword

Salivary gland development; Morphogenesis of salivary gland; Rodent salivary glands

MeSH Terms

Acinar Cells
Aging
Head and Neck Neoplasms
Humans
Morphogenesis
Radiotherapy
Regeneration*
Rodentia
Saliva
Salivary Glands*
Sjogren's Syndrome
Time Factors
Xerostomia

Figure

• 

  Fig. 1. Anatomy of the anterior neck portions of developing salivary glands of mice (a-c). Embryonic day 16.5 (E16.5), post-natal day 0 (PN0) and adult mice showing the location of parotid gland, submandibular gland and sublingual gland. Scale bars, 1 mm.

• 

  Fig. 2. Hematoxylin and eosin staining of the developing parotid gland (PG; a, c, e) and sublingual gland (SLG; b, d, f). Embryonic day 15.5 PG showing epithelial bud (a). Post-natal day 0 (PN0) PG showing terminal epithelial buds (c). Adult PG showing dark-colored acinar cells which characterizes serous acinar cell (e). E15.5 SLG with developing epithelial end buds and lumen formation (b). PN0 showing terminal tu-bules and differentiating acinar cells (d). Adult SLG showing light-colored acinar cells which characterizes mucous acinar cells (f). TT terminal tubule, ED excretory duct, SC serous acinar cell, ME myoepithelial cell, MC mucous acinar cell.

Reference

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