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Derivation of endothelial cells from porcine induced pluripotent stem cells by optimized single layer culture system

Wei R, Lv J, Li X, Li Y, Xu Q, Jin J, Zhang Y, Liu Z

Regenerative therapy holds great promise in the development of cures of some untreatable diseases such as cardiovascular diseases, and pluripotent stem cells (PSCs) including induced PSCs (iPSCs) are the most...
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Human Induced Pluripotent Stem Cells: Clinical Significance and Applications in Neurologic Diseases

Chang EA, Jin SW, Nam MH, Kim SD

The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of...
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Comparative Evaluation of Hormones and Hormone-Like Molecule in Lineage Specification of Human Induced Pluripotent Stem Cells

Choi SA, An JH, Lee SH, Lee GH, Yang HJ, Jeong PS, Cha JJ, Lee S, Park YH, Song BS, Sim BW, Kim YH, Kim JS, Jin YB, Huh JW, Lee SR, Lee JH, Kim SU

BACKGROUND AND OBJECTIVES: Proficient differentiation of human pluripotent stem cells (hPSCs) into specific lineages is required for applications in regenerative medicine. A growing amount of evidences had implicated hormones and...
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Alteration of Genomic Imprinting Status of Human Parthenogenetic Induced Pluripotent Stem Cells during Neural Lineage Differentiation

Lee HJ, Choi NY, Lee SW, Lee Y, Ko K, Kim GJ, Hwang HS, Ko K

BACKGROUND AND OBJECTIVES: Genomic imprinting modulates growth and development in mammals and is associated with genetic disorders. Although uniparental embryonic stem cells have been used to study genomic imprinting, there...
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Reprogramming of Cancer Cells into Induced Pluripotent Stem Cells Questioned

Bang JS, Choi NY, Lee M, Ko K, Park YS, Ko K

BACKGROUND AND OBJECTIVES: Several recent studies have claimed that cancer cells can be reprogrammed into induced pluripotent stem cells (iPSCs). However, in most cases, cancer cells seem to be resistant...
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Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta

Bamba Y, Nonaka M, Sasaki N, Shofuda T, Kanematsu , Suemizu H, Higuchi Y, Pooh RK, Kanemura Y, Okano H, Yamasaki M

STUDY DESIGN: We established induced pluripotent stem cells (iPSCs) and neural stem/progenitor cells (NSPCs) from three newborns with spina bifida aperta (SBa) using clinically practical methods. PURPOSE: We aimed to develop...
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CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells

Kim EJ, Kang KH, Ju JH

Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology—and particularly...
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Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease

Son MY, Lee MO, Jeon H, Seol B, Kim JH, Chang JS, Cho YS

Autoimmune diseases (AIDs), a heterogeneous group of immune-mediated disorders, are a major and growing health problem. Although AIDs are currently treated primarily with anti-inflammatory and immunosuppressive drugs, the use of...
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Questions Surrounding iPS Cells in Japan

Yui Y

No abstract available.
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Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS

Park JH, Park HS, Hong S, Kang S

Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease characterized by the loss of motor neurons in the spinal cord and brain. Mutations in Cu/Zn superoxide dismutase 1 (SOD1)...
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Functional Comparison of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells as Sources of Hepatocyte-Like Cells

Jeong J, Kim KN, Chung MS, Kim HJ

Pluripotent stem cells can differentiate into many cell types including mature hepatocytes, and can be used in the development of new drugs, treatment of diseases, and in basic research. In...
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Highly Efficient Reprogramming and Characterization of Induced Pluripotent Stem Cells by Using a Microwell Array

Lee H, Kim GM, Choi JH, Park MH, Bae JS, Jin HK

Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) enables the possibility of generating patient-specific cells. However, the low efficiency issue associated with iPSCs generation has limited iPSCs...
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Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research

Kim S, Kim MK, Oh D, Lee SH, Kim B

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a valuable opportunity to study neurodevelopmental and neurodegenerative psychiatric diseases by offering an unlimited source for patient-specific neuronal and...
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Induced Pluripotent Stem Cells: Next Generation Stem Cells to Clinical Applications

Cha J, Park S, Lee SB

Induced pluripotent stem cells (iPSC) are specially manipulated cells from somatic cells by the introduction of four factors that are reprogrammed. The properties of iPSC are similar to embryonic stem...
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Application of Induced Pluripotent Stem Cells in Rheumatology

Jung SM, Ju JH

Since induced pluripotent stem cell (iPSC) was first introduced by Yamanaka in 2006, it took only six years to win a Nobel Prize for his pioneering work. It is unusual...
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