- The role of placental indoleamine 2,3-dioxygenase in human pregnancy
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Kudo Y
- KMID: 2313952
- Obstet Gynecol Sci.
- 2013 Jul;56(4):209-216.
Munn et al. made a scientific observation of major biological importance. For the first time they showed that in the mammal the fetus does survive an immune attack mounted by... -
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- Expression of Local Immunosuppressive Factor, Indoleamine 2,3-dixygenase, in Human Coreal Cells
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Ryu YH, Kim JC
- KMID: 2337510
- J Korean Ophthalmol Soc.
- 2007 Aug;48(8):1126-1133.
PURPOSE: To identify the localization of indoleamine 2,3-dioxygenase (IDO) in human corneal cells and to evaluate its ability to act as a local immunosuppressive factor. METHODS: The expression profile of IDO... -
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- The tryptophan utilization concept in pregnancy
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Badawy AA
- KMID: 1841535
- Obstet Gynecol Sci.
- 2014 Jul;57(4):249-259.
- doi: 10.5468/ogs.2014.57.4.249
The decrease in maternal plasma total (free + albumin-bound) tryptophan (Trp) during the third pregnancy trimester is attributed to induction of indoleamine 2,3-dioxygenase (IDO). When measured, free [Trp] is increased... -
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- Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype
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Arandi N, Ramzi M, Safaei F, Monabati A
- KMID: 2429303
- Blood Res.
- 2018 Dec;53(4):294-298.
- doi: 10.5045/br.2018.53.4.294
BACKGROUND: Production of immunosuppressive enzymes such as indoleamine 2,3-dioxygenase (IDO) is one of the strategies employed by hematologic malignancies, including acute myeloid leukemia (AML), to circumvent immune surveillance. Moreover, IDO... -
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- Induction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis
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Ryu DB, Lim JY, Lee SE, Park G, Min CK
- KMID: 2362800
- Immune Netw.
- 2016 Dec;16(6):358-365.
- doi: 10.4110/in.2016.16.6.358
Mesenchymal stem cells (MSCs) have been used experimentally for treating inflammatory disorders, partly owing to their immunosuppressive properties. The goal of the study was to determine whether TLR ligands can... -
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- Matrix Metalloproteinase Inhibitors Attenuate Neuroinflammation Following Focal Cerebral Ischemia in Mice
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Park CH, Shin TK, Lee HY, Kim SJ, Lee WS
- KMID: 2285416
- Korean J Physiol Pharmacol.
- 2011 Apr;15(2):115-122.
- doi: 10.4196/kjpp.2011.15.2.115
The aim of this study was to investigate whether matrix metalloproteinase (MMP) inhibitors attenuate neuroinflammation in an ischemic brain following photothrombotic cortical ischemia in mice. Male C57BL/6 mice were anesthetized,... -
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- Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice
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Hwang SA, Kim CD, Lee WS
- KMID: 2398560
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):101-110.
- doi: 10.4196/kjpp.2018.22.1.101
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury... -
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- Inhibition of Indoleamine 2,3-Dioxygenase Enhances the Therapeutic Efficacy of Immunogenic Chemotherapeutics in Breast Cancer
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Gao J, Deng F, Jia W
- KMID: 2450115
- J Breast Cancer.
- 2019 Jun;22(2):196-209.
- doi: 10.4048/jbc.2019.22.e23
PURPOSE: Breast cancer has become a major public health threat in the current society. Anthracycline doxorubicin (DOX) is a widely used drug in breast cancer chemotherapy. We aimed to investigate... -
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- Suppression of in vitro murine T cell proliferation by human adipose tissue-derived mesenchymal stem cells is dependent mainly on cyclooxygenase-2 expression
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Kim JH, Lee YT, Hong JM, Hwang YI
- KMID: 2046767
- Anat Cell Biol.
- 2013 Dec;46(4):262-271.
- doi: 10.5115/acb.2013.46.4.262
Mesenchymal stem cells (MSCs) of human origin have been frequently applied to experimental animal models to evaluate their immunomodulatory functions. MSCs are known to be activated by cytokines from T... -
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- Expression of COX-2 and IDO by Uteroglobin Transduction in NSCLC Cell Lines
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Park GM, Lee SM, Yim JJ, Yang SC, Yoo CG, Lee CT, Han SK, Shim YS, Kim YW
- KMID: 2319164
- Tuberc Respir Dis.
- 2009 Apr;66(4):274-279.
BACKGROUND: Uteroglobin (UG) is a secretary protein that has strong immunomodulatory properties, and which is synthesized in most epithelia including lung tissue. Overexpression of UG is associated with decreased expression... -
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- Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases
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Ünüvar S, Erge D, Kılıçarslan B, Gözükara Bağ HG, Çatal F, Girgin G, Baydar T
- KMID: 2431606
- Ann Lab Med.
- 2019 May;39(3):284-290.
- doi: 10.3343/alm.2019.39.3.284
BACKGROUND: Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-γ) stimulation. We investigated... -
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- Immune Regulatory Function of Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase in Orally Tolerance to Type II Collagen-induced Animal Model
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Park MJ, Min SY, Park KS, Cho ML, Cho YG, Min JK, Yoon CH, Park SH, Kim HY
- KMID: 1846709
- Immune Netw.
- 2005 Dec;5(4):221-231.
- doi: 10.4110/in.2005.5.4.221
BACKGROUND: Immune regulatory dendritic cells (DCs) play an important role in maintaining self-tolerance. Recent evidences demonstrate that DCs expressing indoleamine 2,3-dioxygenase (IDO), which is involved in tryptophan catabolism, play an... -
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- Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2
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Lee YK, Lee HB, Shin DM, Kang MJ, Yi EC, Noh S, Lee J, Lee C, Min CK, Choi EY
- KMID: 2155386
- Exp Mol Med.
- 2014 Nov;46(11):e121.
- doi: 10.1038/emm.2014.69
Indoleamine 2,3-dioxygenases (IDOs) are tryptophan-catabolizing enzymes with immunomodulatory functions. However, the biological role of IDO2 and its relationship with IDO1 are unknown. To assess the relationship between IDO2 and IDO1,... -
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- Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10
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Yang SH, Park MJ, Yoon IH, Kim SY, Hong SH, Shin JY, Nam HY, Kim YH, Kim B, Park CG
- KMID: 1123805
- Exp Mol Med.
- 2009 May;41(5):315-324.
- doi: 10.3858/emm.2009.41.5.035
Mesenchymal stem cells (MSCs) can inhibit T cell proliferation; however, the underlying mechanisms are not clear. In this study, we investigated the mechanisms of the immunoregulatory activity of MSCs on... -
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- Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts
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Park MK, Oh HJ, Heo YM, Park EM, Cho ML, Kim HY, Park SH
- KMID: 1022119
- Exp Mol Med.
- 2011 Aug;43(8):446-454.
- doi: 10.3858/emm.2011.43.8.050
Indoleamine 2,3-dioxygenase (IDO) is a key negative regulator of immune responses and has been implicated in tumor tolerance, autoimmune disease and asthma. IDO was detected in the joint synovial tissue... -
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- Human bone marrow-derived mesenchymal stem cell gene expression patterns vary with culture conditions
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Lee MW, Kim DS, Yoo KH, Kim HR, Jang IK, Lee JH, Kim SY, Son MH, Lee SH, Jung HL, Sung KW, Koo HH
- KMID: 2172908
- Blood Res.
- 2013 Jun;48(2):107-114.
- doi: 10.5045/br.2013.48.2.107
BACKGROUND: Because of the heterogeneity of human mesenchymal stem cells (MSCs), methods for cell expansion in culture and the effects on gene expression are critical factors that need to be... -
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- Cyclooxygenase-2 (COX-2) Inhibitors Reduce Immune Tolerance through Indoleamine 2,3-dioxygenase (IDO)
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Lee SY, Lee KJ, Jung JY, Lee EJ, Kang EH, Jung KH, Lee SY, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Yoo SH
- KMID: 2200111
- J Lung Cancer.
- 2007 Jun;6(1):15-23.
- doi: 10.6058/jlc.2007.6.1.15
PURPOSE : Cyclooxygenase-2 (COX-2) and its metabolite, PGE2 affect multiple tumorigenesis, including angiogenesis, invasion, and tumor-induced immune suppression. Their overexpression is association with impaired immune cell function in many tumors.... -
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- Immunomodulatory effects of human amniotic membrane-derived mesenchymal stem cells
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Kang JW, Koo HC, Hwang SY, Kang SK, Ra JC, Lee MH, Park YH
- KMID: 1364999
- J Vet Sci.
- 2012 Mar;13(1):23-31.
- doi: 10.4142/jvs.2012.13.1.23
Human amniotic membrane-derived mesenchymal stem cells (hAM-MSCs) are capable of differentiating into several lineages and possess immunomodulatory properties. In this study, we investigated the soluble factor-mediated immunomodulatory effects of hAM-MSCs.... -
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