- A Novel Osteogenic Activity of Suberoylanilide Hydroxamic Acid is Synergized by BMP-2
-
Lee ZH, Kim HJ, Ryoo HM
- KMID: 2170088
- J Bone Metab.
- 2015 May;22(2):51-56.
- doi: 10.11005/jbm.2015.22.2.51
BACKGROUND: Many histone deacetylase (HDAC) inhibitors are well recognized as potential anti-cancer drugs. Inhibition of HDACs induces temporal transcription or epigenetic control, thus regulating many different biological responses. Here, we... -
- CITED
-
- Close
- SHARE
-
- Close
- The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells
-
Jin KL, Park JY, Noh EJ, Hoe KL, Lee JH, Kim JH, Nam JH
- KMID: 2173551
- J Gynecol Oncol.
- 2010 Dec;21(4):262-268.
- doi: 10.3802/jgo.2010.21.4.262
OBJECTIVE: To investigate the combined effects of cisplatin and the histone deacetylase (HDAC) inhibitors suberoylanilide hydroxamic acid (SAHA) or sirtinol on HeLa cells and assess the mechanism underlying HDAC inhibitor-cisplatin... -
- CITED
-
- Close
- SHARE
-
- Close
- Localized Scleroderma-like Reaction Induced by Doxifluridine
-
Lee KM, Cho AY, Lee Y, Seo YJ, Park JK, Lee JH
- KMID: 1472464
- Korean J Dermatol.
- 2009 Jan;47(1):95-97.
Exogenous factors, including environmental substances and drugs, are known to induce scleroderma-like reactions. Various scleroderma-like reactions induced by anti-cancer drugs have recently been reported. This is the first report that... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-Cancer Effect of 3-(4-dimethylamino phenyl)-N-hydroxy-2-propenamide in MCF-7 Human Breast Cancer
-
Min KN, Joung KE, Kim DK, Sheen YY
- KMID: 2380177
- Environ Health Toxicol.
- 2012 ;27(1):e2012010.
OBJECTIVES: In recent years, a number of structurally diverse Histone deacetylase (HDAC) inhibitors have been identified and these HDAC inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in... -
- CITED
-
- Close
- SHARE
-
- Close
- Clinical Characteristics of Primary Headache According to Age in Children and Adolescents
-
Hong YJ, Kim MS, Lee KY, Sim CS
- KMID: 2176837
- J Korean Child Neurol Soc.
- 2010 Nov;18(2):264-274.
PURPOSE: Childhood headache is different from adulthood headache and according to their age in clinical aspects. This study investigated the clinical differences of primary headache according to ages of children... -
- CITED
-
- Close
- SHARE
-
- Close
- Innovative In Vitro Chemo-Hormonal Drug Therapy for Refractory Thyroid Carcinomas
-
Sung TY, Choi SH, Lee JM, Jeong JJ, Kang SW, Chung WY
- KMID: 2157915
- J Korean Med Sci.
- 2012 Jul;27(7):729-735.
- doi: 10.3346/jkms.2012.27.7.729
More than 95% of the thyroid carcinomas are well differentiated types showing favorable prognosis. However, only a few therapeutic options are available to treat the patients with undifferentiated thyroid carcinomas,... -
- CITED
-
- Close
- SHARE
-
- Close
- Epidemiological Prevalence of Avian Pathogenic Escherichia coli Differentiated by Multiplex PCR from Commercial Chickens and Hatchery in Korea
-
Kwon SG, Cha SY, Choi EJ, Kim B, Song HJ, Jang HK
- KMID: 1483958
- J Bacteriol Virol.
- 2008 Dec;38(4):179-188.
- doi: 10.4167/jbv.2008.38.4.179
We examined 216 Escherichia coli (E. coli) isolated from chickens and environmental specimens from hatcheries between 2005 and 2006 in order to evaluate the epidemiological prevalence of avian pathogenic E.... -
- CITED
-
- Close
- SHARE
-
- Close
- Osteoblast differentiation of human bone marrow stromal cells (hBMSC) according to age for bone tissue engineering
-
Song GA, Ryoo HM, Choi JY
- KMID: 1457774
- J Korean Assoc Oral Maxillofac Surg.
- 2010 Aug;36(4):243-249.
- doi: 10.5125/jkaoms.2010.36.4.243
Tissue engineered bone (TEB) can replace an autogenous bone graft requiring an secondary operation site as well as avoid complications like inflammation or infection from xenogenic or synthetic bone graft.... -
- CITED
-
- Close
- SHARE
-
- Close
- Pharmacological Unmasking Microarray Approach-Based Discovery of Novel DNA Methylation Markers for Hepatocellular Carcinoma
-
Jung N, Won JK, Kim BH, Suh KS, Jang JJ, Kang GH
- KMID: 1421610
- J Korean Med Sci.
- 2012 Jun;27(6):594-604.
- doi: 10.3346/jkms.2012.27.6.594
DNA methylation is one of the main epigenetic mechanisms and hypermethylation of CpG islands at tumor suppressor genes switches off these genes. To find novel DNA methylation markers in hepatocellular... -
- CITED
-
- Close
- SHARE
-
- Close
- Induction of Apoptosis in Intestinal Toxicity to a Histone Deacetylase Inhibitor in a Phase I Study with Pelvic Radiotherapy
-
Kalanxhi E, Risberg K, Barua IS, Dueland S, Waagene S, Andersen S, Pettersen , Lindvall J, Redalen KR, Flatmark K, Ree AH
- KMID: 2378109
- Cancer Res Treat.
- 2017 Apr;49(2):374-386.
- doi: 10.4143/crt.2016.080
PURPOSE: When integrating molecularly targeted compounds in radiotherapy, synergistic effects of the systemic agent and radiation may extend the limits of patient tolerance, increasing the demand for understanding the pathophysiological... -
- CITED
-
- Close
- SHARE
-
- Close
- Comparison between Therapeutic Efficacies of Histone Deacetylase Inhibitors and Established Drug Regimens Against Breast Cancer Cells using the Histoculture Drug Response Assay
-
Seo JY, Lee YM, Cho DH, Roh SA, Ro SG, Hyun YL, Kim SY, Kim YS, Kim TW, Ahn SH, Kim JC
- KMID: 2175513
- J Breast Cancer.
- 2009 Dec;12(4):241-248.
- doi: 10.4048/jbc.2009.12.4.241
PURPOSE: Histone deacetylase inhibitors (HDACIs) induce accumulation of acetylated histones in nucleosomes, which lead to reactivate gene expression and inhibit the growth and survival of tumor cells. This study evaluated... -
- CITED
-
- Close
- SHARE
-
- Close
- Transactivation of bad by vorinostat-induced acetylated p53 enhances doxorubicin-induced cytotoxicity in cervical cancer cells
-
Lee SJ, Hwang SO, Noh EJ, Kim DU, Nam M, Kim JH, Nam JH, Hoe KL
- KMID: 2155341
- Exp Mol Med.
- 2014 Feb;46(2):e76.
- doi: 10.1038/emm.2013.149
Vorinostat (VOR) has been reported to enhance the cytotoxic effects of doxorubicin (DOX) with fewer side effects because of the lower DOX dosage in breast cancer cells. In this study,... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of alpha-lipoic Acid on Differentiation of Thyroid Cancer Cells
-
Kim WG, Han DH, Choi HJ, Kim EY, Kim TY, Shong YK, Kim WB
- KMID: 2177858
- J Korean Endocr Soc.
- 2010 Mar;25(1):28-36.
- doi: 10.3803/jkes.2010.25.1.28
BACKGROUND: Induction of re-differentiation is necessary for the proper treatment of patients with recurrent or metastatic differentiated thyroid cancer (DTC) because cancer cells show de-differentiation in about 30% of these... -
- CITED
-
- Close
- SHARE
-
- Close
- Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A
-
Tran HT, Kim HN, Lee IK, Nguyen-Pham TN, Ahn JS, Kim YK, Lee JJ, Park KS, Kook H, Kim HJ
- KMID: 1429188
- J Korean Med Sci.
- 2013 Feb;28(2):237-246.
- doi: 10.3346/jkms.2013.28.2.237
SUV39H1 is a histone 3 lysine 9 (H3K9)-specific methyltransferase that is important for heterochromatin formation and the regulation of gene expression. Chaetocin specifically inhibits SUV39H1, resulted in H3K9 methylation reduction... -
- CITED
-
- Close
- SHARE
-
- Close
- Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
-
Choi Y, Park SK, Kim HM, Kang JS, Yoon YD, Han SB, Han JW, Yang JS, Han G
- KMID: 1104812
- Exp Mol Med.
- 2008 Oct;40(5):574-581.
- doi: 10.3858/emm.2008.40.5.574
In light of the anti-inflammatory properties of histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), we examined a new HDAC inhibitor KBH-A42 for its... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1
-
Kang JH, Kim SA, Chang SY, Hong S, Hong KJ
- KMID: 1047092
- Exp Mol Med.
- 2007 Jun;39(3):402-411.
Expression of thrombospondin-1 (TSP-1), which is a known inhibitor of tumor growth and angiogenesis, is reciprocally regulated by positive regulators, such as VEGF. Additionally, trichostatin A (TSA) suppresses tumor progression... -
- CITED
-
- Close
- SHARE
-
- Close
- Trichostatin A-mediated upregulation of p21
-
Yi T, Baek JH, Kim HJ, Choi MH, Seo SB, Ryoo HM, Kim GS, Woo KM
- KMID: 1094662
- Exp Mol Med.
- 2007 Apr;39(2):213-221.
Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about... -
- CITED
-
- Close
- SHARE
-
- Close
- Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells
-
Kim TY, Kim IS, Jong HS, Lee JW, Kim TY, Jung M, Bang YJ
- KMID: 1072944
- Exp Mol Med.
- 2008 Dec;40(6):639-646.
- doi: 10.3858/emm.2008.40.6.639
We previously reported that trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, induced DLC-1 mRNA expression and accumulated acetylated histones H3 and H4 associated with the DLC-1 promoter in DLC-1... -
- CITED
-
- Close
- SHARE
-
- Close
- Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway
-
Kim HR, Kim EJ, Yang SH, Jeong ET, Park C, Lee JH, Youn MJ, So HS, Park R
- KMID: 1115939
- Exp Mol Med.
- 2006 Dec;38(6):616-624.
Trichostatin A (TSA), originally developed as an antifungal agent, is one of potent histone deacetylase (HDAC) inhibitors, which are known to cause growth arrest and apoptosis induction of transformed cells,... -
- CITED
-
- Close
- SHARE
-
- Close
- ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response
-
Jang ER, Choi JD, Park MA, Jeong G, Cho H, Lee JS
- KMID: 946652
- Exp Mol Med.
- 2010 Mar;42(3):195-204.
- doi: 10.3858/emm.2010.42.3.020
Chromatin structure has a crucial role in a diversity of physiological processes, including development, differentiation and stress responses, via regulation of transcription, DNA replication and DNA damage repair. Histone deacetylase... -
- CITED
-
- Close
- SHARE
-
- Close
