Korean J Dermatol.  2009 Jan;47(1):95-97.

Localized Scleroderma-like Reaction Induced by Doxifluridine

• Lee KM
• Cho AY
• Lee Y
• Seo YJ
• Park JK
• Lee JH

Abstract

Exogenous factors, including environmental substances and drugs, are known to induce scleroderma-like reactions. Various scleroderma-like reactions induced by anti-cancer drugs have recently been reported. This is the first report that doxifluridine (Didox), an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU), induced a localized sclerderma-like reaction. A 51-year-old woman was referred to our clinic with multiple pearly, shiny patches on both her breasts, her pelvis and her back. After surgical excision and radiation therapy due to her right breast cancer, she took Didox for 7 months. A skin biopsy specimen revealed that the dermal collagen thickening extended even to the subcutaneous tissue. The routine laboratory tests were within the normal ranges and the tests for antinuclear antibody (ANA), anti SS-A antibody, anti SS-B antibody and anti U1-RNP antibody were all negative. After discontinuation of Didox, the lesions gradually improved. Based on these finding, we diagnosed this case as a localized scleroderma-like reaction induced by doxifluridine and we should pay attention to detect this adverse effect of the long term use of doxifluridine.

Keyword

Doxifluridine; Localized scleroderma-like reaction

MeSH Terms

Antibodies, Antinuclear
Biopsy
Breast
Breast Neoplasms
Collagen
Female
Floxuridine
Fluorouracil
Humans
Hydroxamic Acids
Middle Aged
Pelvis
Reference Values
Skin
Subcutaneous Tissue
Antibodies, Antinuclear
Collagen
Floxuridine
Fluorouracil
Hydroxamic Acids