- Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis
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Park H, Lee M, Kim DW, Hong SY, Lee H
- KMID: 2378571
- Obstet Gynecol Sci.
- 2016 Nov;59(6):470-478.
- doi: 10.5468/ogs.2016.59.6.470
OBJECTIVE: Glycogen synthase kinase 3β (GSK3β) is a pluripotent protein kinase involved in the development of cancers through regulation of numerous oncogenic molecules. Cyclin D1, an important regulator of G1... -
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- Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau
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Kim SI, Lee WK, Kang SS, Lee SY, Jeong MJ, Lee HJ, Kim SS, Johnson GV, Chun W
- KMID: 2285415
- Korean J Physiol Pharmacol.
- 2011 Apr;15(2):107-114.
- doi: 10.4196/kjpp.2011.15.2.107
Neurofibrillary tangle (NFT) is a characteristic hallmark of Alzheimer's disease. GSK3beta has been reported to play a major role in the NFT formation of tau. Dysfunction of autophagy might facilitate... -
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- Immunohistochemical Study on the Distribution of Glycogen Synthase Kinase (GSK) 3beta in the Central Nervous System of SOD1G93A Transgenic Mice
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Joo KM, Chung YH, Kim SS, Kim KY, Lee WB, Cha CI
- KMID: 1521308
- Korean J Phys Anthropol.
- 2007 Dec;20(4):355-362.
In the present study, we investigated influences of glycogen synthase kinase (GSK) 3beta on the development and/or progression of amyotrophic lateral sclerosis (ALS). We used transgenic mice expressing a human... -
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- Effects of chronic alcohol exposure on ischemia–reperfusion-induced acute kidney injury in mice: the role of β-arrestin 2 and glycogen synthase kinase 3
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Wang L, Zhu Y, Wang L, Hou J, Gao Y, Shen L, Zhang J
- KMID: 2386967
- Exp Mol Med.
- 2017 Jun;49(6):e347.
- doi: 10.1038/emm.2017.76
Little is known about the effects of chronic alcohol intake on the outcome of acute kidney injury (AKI). Hence, we examined the effects of chronic alcohol intake on the development... -
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- Anti-diabetic effects of benfotiamine on an animal model of type 2 diabetes mellitus
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Chung KM, Kang W, Kim DG, Hong HJ, Lee Y, Han CH
- KMID: 1700786
- Korean J Vet Res.
- 2014 Mar;54(1):21-26.
Although benfotiamine has various beneficial anti-diabetic effects, the detailed mechanisms underlying the impact of this compound on the insulin signaling pathway are still unclear. In the present study, we evaluated... -
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- Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1
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Kim Y, Kim J, Ahn M, Shin T
- KMID: 2390482
- Anat Cell Biol.
- 2017 Sep;50(3):207-213.
- doi: 10.5115/acb.2017.50.3.207
Glycogen synthase kinase (GSK)-3β and related enzymes are associated with various forms of neuroinflammation, including spinal cord injury (SCI). Our aim was to evaluate whether lithium, a non-selective inhibitor of... -
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- GSK3beta Inhibitor Peptide Protects Mice from LPS-induced Endotoxin Shock
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Ko R, Jang HD, Lee SY
- KMID: 2150666
- Immune Netw.
- 2010 Jun;10(3):99-103.
- doi: 10.4110/in.2010.10.3.99
BACKGROUND: Glycogen synthase kinase 3beta (GSK3beta) is a ubiquitous serine/threonine kinase that is regulated by serine phosphorylation at 9. Recent studies have reported the beneficial effects of a number of... -
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- Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
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Kim YM, Song I, Seo YH, Yoon G
- KMID: 2169308
- Endocrinol Metab.
- 2013 Dec;28(4):297-308.
- doi: 10.3803/EnM.2013.28.4.297
BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an... -
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- Potential involvement of glycogen synthase kinase (GSK)-3β in a rat model of multiple sclerosis: evidenced by lithium treatment
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Ahn M, Kim J, Park C, Cho J, Jee Y, Jung K, Moon C, Shin T
- KMID: 2390426
- Anat Cell Biol.
- 2017 Mar;50(1):48-59.
- doi: 10.5115/acb.2017.50.1.48
Glycogen synthase kinase (GSK)-3β has been known as a pro-inflammatory molecule in neuroinflammation. The involvement of GSK-3β remains unsolved in acute monophasic rat experimental autoimmune encephalomyelitis (EAE). The aim of... -
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- The Regulation of ERK, GSK3beta and AKT after Acute Ethanol Exposure and Withdrawal in SH-SY5Y Human Neuroblastoma Cell-line
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Roh J, Cui FJ, Kang UG
- KMID: 2341725
- J Korean Neuropsychiatr Assoc.
- 2010 Mar;49(2):241-247.
OBJECTIVES: This study aimed to demonstrate the activities and phosphorylation changes induced by acute ethanol treatment and withdrawal conditions in the intracellular signal transduction molecules [such as extracellular signal-regulated kinase... -
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- Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
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Ahn K, Kweon S, Kim DW, Lee H
- KMID: 2445073
- Obstet Gynecol Sci.
- 2019 May;62(3):157-165.
- doi: 10.5468/ogs.2019.62.3.157
OBJECTIVE: This study aimed to analyze the expression pattern of glycogen synthase kinase 3β (GSK3β) and its phosphorylated forms, GSK3β phosphorylated at Ser9 (pS9GSK3β), and GSK3β phosphorylated at Tyr216 (pY216GSK3β),... -
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- Suppression of β-catenin Signaling Pathway in Human Prostate Cancer PC3 Cells by Delphinidin
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Lee W, Yun JM
- KMID: 2353811
- J Cancer Prev.
- 2016 Jun;21(2):110-114.
- doi: 10.15430/JCP.2016.21.2.110
Delphinidin possesses strong anti-oxidant, anti-inflammatory, and anti-cancer properties. Suppression of the Wnt/β-catenin signaling pathway is a potential strategy for chemoprevention and therapy. As aberrant activation of the β-catenin signaling pathway... -
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- Ethyl linoleate inhibits α-MSH-induced melanogenesis through Akt/GSK3β/β-catenin signal pathway
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Ko GA, Kim Cho S
- KMID: 2398555
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):53-61.
- doi: 10.4196/kjpp.2018.22.1.53
Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent.... -
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- Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways
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Kwon KJ, Kim HJ, Shin CY, Han SH
- KMID: 1462848
- J Clin Neurol.
- 2010 Sep;6(3):127-137.
- doi: 10.3988/jcn.2010.6.3.127
BACKGROUND AND PURPOSE: Recent studies have demonstrated that resveratrol (RSV) reduces the incidence of age-related macular degeneration, Alzheimer's disease (AD), and stroke, while melatonin (MEL) supplementation reduces the progression of... -
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- Ischemic Postconditioning Inhibits Mitochondrial Permeability Transition Pore via Opioid Receptor Activation in Intact Rat Heart
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Lee YC, Jang YH, Kim JM, Kim AR, Lee SR, Kim YN, Hong JH
- KMID: 2239820
- Korean J Anesthesiol.
- 2008 Mar;54(3):320-327.
- doi: 10.4097/kjae.2008.54.3.320
BACKGROUND: Ischemic postconditioning (Post-C), brief cycles of myocardial ischemia and reperfusion during the early phase of reperfusion, is considered as a novel adjunct strategy to protect myocardium.However, the exact mechanism... -
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- Ezrin-radixin-moesin proteins are regulated by Akt-GSK3β signaling in the rat nucleus accumbens core
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Kim WY, Cai WT, Jang JK, Kim JH
- KMID: 2466576
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):121-126.
- doi: 10.4196/kjpp.2020.24.1.121
The ezrin-radixin-moesin (ERM) proteins are a family of membrane-associated proteins known to play roles in cell-shape determination as well as in signaling pathways. We have previously shown that amphetamine decreases... -
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- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells
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Kim D, Lim JW, Kim H
- KMID: 2468801
- J Cancer Prev.
- 2019 Sep;24(3):192-196.
- doi: 10.15430/JCP.2019.24.3.192
BACKGROUND: Helicobacter pylori infection is a major risk factor in the development of gastric cancer. H. pylori infection of gastric epithelial cells increases the levels of reactive oxygen species (ROS),... -
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- Interaction between Neuronal Depolarization and MK-801 in SH-SY5Y Cells and the Rat Cortex
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Kim Y, Seo M, Lee YI, Kim SY, Cho EA, Kim SH, Ahn YM, Kang UG, Kim YS, Juhnn YS
- KMID: 1706122
- Psychiatry Investig.
- 2008 Jun;5(2):94-101.
- doi: 10.4306/pi.2008.5.2.94
OBJECTIVE: The interaction between MK-801, a model of psychosis and KCl-induced depolarization or electroconvulsive shock (ECS), a therapeutic model of electroconvulsive therapy (ECT), was investigated in SH-SY5Y cells and the... -
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- Role of Akt in Tumorigenesis and Angiogenesis of MC-SV-HUC T2 Cell Line
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Kim MK
- KMID: 1484901
- Korean J Anat.
- 2008 Jun;41(2):111-119.
Protein Kinase B (PKB/Akt) is a serine/threonine kinase that plays important roles in multiple physiological and pathological processes. Specially, Akt activation induces tumorigenesis in many cancers. However, molecular mechanism related... -
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- Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3β signaling in rats
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Wang CY, Li XD, Hao ZH, Xu D
- KMID: 2364265
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):613-619.
- doi: 10.4196/kjpp.2016.20.6.613
Diabetic cardiomyopathy (DCM), a serious complication of diabetes mellitus, is associated with changes in myocardial structure and function. This study sought to explore the ability of insulin-like growth factor-1 (IGF-1)... -
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